DO you have any idea how much DMT will you need and which form (salt, freebase,etc)?

I would contact Brandt (brandt@ljmu.ac.uk ) or Strassman (rickstrassman@earthlink.net).

Start here. Read all about extraction and purification and then come back to ask some specific questions. Wiki is DMT Nexus knowledge - all members experience in one place.

Also try what Shaolin suggested to you. I know that Rick Strassman was also doing some consultation over the phone. It was something like $100 for 30 minutes. Cant remember exactly. He may not be doing it at all now, this was about a year ago. He is the person who had very pure DMT.

good luck

There's no way that a research project will be given permission to synthesize/extract their own DMT. It's going to have to be bought from a chemical supply company.

The desire to want to further our knowledge on these substances is appreciated! But dont get ahead of yourself, one step at the time.

To investigate and publish, when using a standard substance, they will have purchased it from the likes of sigma aldrich or other chemical supply companies, and this is mentioned in the paper. You cant use something you extract at home at least if you dont make sure its very pure using HPLC or such chromatographic techniques, because otherwise how can you know the effects you are seeing are really from pure DMT and not some impurity?

To purchase a substance like DMT legally to use in a research, you must imagine the bureaucratic work... You will have to be affiliated with some university or group with reputation that can ask for it in legal means. And everything is obviously controlled, you're not gonna store the DMT at home, it's all locked up in the university and so on. It can be done, but you need to know where to affiliate yourself. Or if your department has HPLC, you can purify your DMT with a preparative column and do your research and explain that your DMT was purified with HPLC. Rick Strasmann had extra trouble because he was gonna administer it to humans, so you cant just extract and purify, the source must have a lot of guarantees and Rick Strasmann was lucky to have Nichols do it for him. If you do In Vitro work or other things that dont require ingestion, you might get away with just asserting purification instead of source at least in some journals? Better check up more on this, your professor should know.

Then of course there is the issue of money, because any advanced serious research is gonna cost a lot, not only material but all the people involved. To get a research grant, you need to convince somebody with money your research is worth it, and unless you know some rich person with psychedelic interesting, it's not easy to convince the government or universities to give you these grants.

And then of course there's underground research.. Most dont get published, but lets say when somebody does a side-by-side extraction comparing a solvent versus other, or a temperature versus other, or a clean up versus other, these things are incredibly useful for the community to know, and yet there seem to be few of these tests around. If you get to develop your own extractions, you can always share the results and it will be very appreciated.

Keep us informed on your developments, whether official or not. Be well

Cozzi and Nichols are not in positions to supply this material for international research. Suggest finding the best teks on the Nexus and ensure your research institute is completely aware of your intentions. Keep meticulous notebooks and secure the material. HPLC on a prep scale will provide you with the quality needed, confirmed by LC mass spec.

teks shmeks..

just use an SPE column. that's the way to do it before putting it into HPLC-UV-MS (you use UV to determine purity, and a flow-splitter from the detector to collect fractions)

Since it will be however a huge extraction (no matter how much we need which i don't know for now)...

i thought that making a very A/B extraction will solve me the problem to manage a lot of plant solid cake materials? do you understand what i mean?

i thougt to sink the powder in a HCl or a Glacial Acetic Acid solution for many days mixing well...... and then retrieve only the liquid part filtering the solid part which will be a problem with other stuff....
then i will reduce this eluate to manage it better later....

@benzyme: does this procedure would avoid the need of SPE ? and make me go directly to HPLC??? or does some solid part will remain however inside and i have to run SPE in any case?

ps.. for SHMEK you soxhlet separation with MEK ? or just methanol?

please correct me but i think that soxhlet and spe have not enough space for all the stuff and run tons of those will be a waste of time and energy since i the case i shown i'll get only a small ammount of DMT solution to run hplc.... am i right? please correct me


and sorry for my english!

i think he just made a rhyme of TEK for a joke

what he meant was probably, instead of going through details of different teks here on the forum, just use the method he reffered to..

The Shmek part i think was a joke ,something like a "saying" : "Money Shmoney". Propably he means to go for something other than "the average tek you will find here".

correct.

a quick and dirty A/B will suffice for these purposes, before running it through an SFE column. the teks on the nexus are fairly elaborate, for getting stunningly clean crystals...
but since you're going to run it through an HPLC anyway, the end result will be purer.

and you should ask the private investigator all the questions you have, since you're going to invest your time in this.. learn EVERY method well, not just the ones you're interested in. This is where a lot of grad students limit themselves like suckers.

yea that.
(the person who got to where he/she is by mastering the art of bs'ing.)

sry, i had too much drugs

I'll go with some of the others who advised you to contact people like Rick Strassman, before going on ahead.
Such otherwise illegal extraction/synthesises probably require official inquiries & official consent of the
local authorities. Much like Alexander Shulgin went to great lengths to get the official green light from
the DEA to do the work he did; And even that didn't turn up to be fool proof when the DEA got new leadership
& headed in a new, much less tolerant direction.

So just going ahead and extracting DMT definately will be a legal no-no.
Contact Rick Strassman & ask him how he went about getting official
governemtnal approval to make DMT & use it in his experiments. Try
to follow those exact steps.