HI!! I was wondering what MAO inhibition is on a molecular level? Does MAOI engulf MAO molecules? Or does MAOI stop MAO from being produced? How does the inhibition take place?

Also, will taking MAOI orally inhibit the production throughout the whole body, or just the stomach? I was wondering because I am thinking of a different way of taking mimosa tea. I notice that mimosa tea always has some heavier material that sinks to the bottom of the glass. The heavy stuff is the most tannic, and if I drink it, I will barf severely. But the heavy stuff seems to be rich with actives, but I don't want to drink it, and I also don't want to throw it out. So, my solution is to take the sandy tannic stuff as an enema, but drink the rest of the tea. Just wondering if I would have to take harmala both orally and anally for such a thing? This method would ensure full usage of all the goodies in mimosa, without a guaranteed purge before actives are absorbed. THANKS!

Enzymes are amazing little biological machines...

Here is a simple animation to demonstrate:

http://www.youtube.com/watch?v=PILzvT3spCQ

Doesn't rectal administration bypass the gut anyway? Wouldn't this mean that any RIMA/DMT taken rectally would go straight to the liver to be metabolized? I'd think you'd be fine to do this as far as maintaining the integrity of your dose, but hey, what do I know...

take the mimosa precips once you pour off the clear tea and strain them through a t shirt filter..squeeze it to get all the liquid out of it and add it to the rest of the tea..if more stuff drops out a day later do the same thing until nothing drops out anymore. That is what I do.

[quote=SnozzleBerry]Doesn't rectal administration bypass the gut anyway? Wouldn't this mean that any RIMA/DMT taken rectally would go straight to the liver to be metabolized?



The rectum has 2 distinct levels in terms of differing blood supply, neural innervation and lymph drainage.The upper parts' venous drainage is into the portal system, but the lower part drains into the systemic circulation. Some drugs which are used in practise may be mostly metabolised in the liver but can still achieve a very good venous concentration when given rectally because of this different venous drainage.And this is why this route is used to quell epileptic seizures using rectal diazepam-and its impressive how quick it actually stops the fits.The lower rectum is where access to the systemic circulation 'sits'

Ahhhh, cool! Thanks for the physiology briefing. This would leave my initial conjecture intact, yes? That is, it would be similar to dosing orally and then sublingually, or otherwise combining RoA...there should be some degree of cumulative effect, correlating to the overlap in the metabolization of the substances dosed through the different RoA.

thanks for the explanation, dtrypt



I have read that the intestines do contain mao's.

Thanks, Jamie, I will try your suggestion.

Update: I tried this method of combining oral with anal use and I have concluded it does not work as intended. First I drank the tea. Then about 50 minutes later, whenever the initial nausea from drinking the mimosa subsides, I take the enema. The result has been the same both times, and that is I throw up within 10 minutes of taking the enema. Before taking the enema, I felt ok, like I wasn't going to throw up. Although an enema does not really causes nausea per se, it does cause some bloating sensations and weird cramping and discomfort in the whole GI area. The combination of mimosa in the stomach and in the ass causes a purge.... for me anyway. An enema alone will not cause a purge, but combining an enema with tea will cause purge.

Perhaps it would only work with relatively pure dmt? May not be very comfortable though.

how diluted was the enema?