I’ve been recently wondering why SWIM gets sick when he snorts a substance. It doesn’t matter what the substance is. All substances either make him feel sick, or make him sneeze the material out. If he can manage not to sneeze the stuff out, his nose gets runny, he starts feeling pressure in his nose, he feels a little nausea, and gets a mild sinus headache.

What causes this?

Why are some people able to snort things without getting these symptoms?

Is there a way to stop this reaction?

This may not be the reason but if the first time you snorted something you had a bad experience or it was painful... this may have conditioned you to exhibit this type of response. This happened to a friend of mine every time he would snort opiates they would gage because he had thrown up the first few times he did it. If possible try conditioning yourself by using small amounts. Maybe use a little amount in each nostril (even though it ends up in the same place) over a few minutes or do a little bit just to get yourself use to it and keep increasing the amount over several days. Also it may be possible with some compounds to dissolve them in a small amount of water and try snuffing this as it shouldn't make you sneeze.
This may just be how your body reacts, it which case their is not much you can do except avoid it. I think however one could train themselves to overcome this negative response.

that snorting water gave me an idea...have you heard of a neti(sp?) pot? its a pot you use to run saline through your nose to clean it out...well what if you dissolved a compound in your water and ran the water through your sinuses...i wonder what would happen...the tek would need to be figured out but it might just work...that way you can ingest a chemical without snorting it...and also it may increase absorption because its in a water solution...

This would absolutely work so long as the amount of water was low enough to stay in the sinus cavity. There are many commercial drug preparations that are administered in this fashion. Including many OTC cold medicines. The salt would have to be used of course and the dosage figured out but this would not be to difficult.

exactly!! it would keep your nose hydrated..and you could also control the pH much better for maximum absorption..

It is definitely a promising idea and should be looked into.

so could you use bufotenine in a salt form this way?!

Would adding DMSO make it more nasally absorbable?

or is any bufo salt really nasty?

that doesnt sound pleasant at all!

Bufo salt would likely be a bad idea all studies done with Bufo pre-Jonathan Ott used the salt with negative effects. A slightly basic solution would be needed with B. DMSO would probably be very very unpleasant but certainly possible. SWIM would stick with an aqueous solution.

perhaps you could freebase it once it was in the solution...that way you could have some bufo fumarate powder..and freebase it in the solution..and then get it that way

This could be done although it would probably require slightly more base and the presence of the fumerate may have some altered affect on absorption via pH or buffering effect. Dissolving freebase B in a small amount of a calcium hydroxide solution would probably be best thus calcium B would also be generated which is rumored to be the most effective preparation.

I believe a liquid solution would be less likely to bother SWIM’s nose.

SWIM has used many nasal sprays before and none of them ever bothered him. It’s the presence of foreign solids that seems to set of SWIM’s negative reaction to snuff.

As far as a salt of bufotenine goes, when SWIM ingests freebase bufotenine orally, the effects are very different, almost like LSA, and it bother’s SWIM stomach (it could be the impurities doing that though). In the stomach freebase bufotenine would convert to bufotenine HCl. I do know that different forms of medications do have different effects. This is a known fact in the pharmaceutical industry. The FDA approves drugs by form. For example, while DMT fumarate is approved for research by the FDA, DMT HCl is not. The same is true for most medications. Some salt forms are toxic, or ineffective, so when a drug is approved by the FDA in a certain salt form, other forms are NOT approved. Each salt form of a drug must be tested and approved separately by the FDA before it can be legally used.

Does DMSO burn your nose? It doesn’t burn SWIM’s mouth.

Calcium hydroxide burns a lot. However, SWIM knows that if you mix calcium hydroxide with freebase bufotenine, and you snort that mix, it is stronger than snorting bufotenine alone. The trip is also better, but the pain is intense. At what pH do the nasal passages get irritated?

According to the Merck Index bufotenine is soluble in both acidic solutions and alkaline solutions, but almost insoluble in pure water. Making an alkaline liquid nasal spray with bufotenine in it should be easy. You’d probably want to use a highly water soluble base like sodium carbonate rather than calcium hydroxide wouldn’t you?

that would be realllly cool

could you possibly keep it as bufo fumarate and then when you wanted to use it..you could mix up a batch of sodium carbonate solution and then put the powdery bufo fumarate in it to freebase..and then squirt away!

Yes Bufoteine freebase would be converted to the HCL salt in the stomach as will all amines. However with most drugs (Not all cases but definitely with simple amines) the primary site of absorption is in the small intestine and thus amines would be converted back into the freebase at this site prior to absorption. Additionally absorption is most effective with the unionized form of a drug. (Ionization can reoccur in the blood or in the tissue and depends on the specific compound and pH of the area). Some organic acids absorb better in the stomach because they are in the unionized form however even still the intestine is the primary site of absorption as it is physiologically designed for such function. I do not believe the pH in the intestine is high enough to ionize the 5-OH of B but I could be wrong either way an equilibrium would be reached between ionized and unionized and as the un-ionized form is absorbed more of the ionized form will shift to the unionized form thus absorption may be slower but would still occur.

True 69ron different salts do have different effects and thus FDA approvals. Different salts certainly ionize to greater extents and would thus have different effectiveness. Oxalate salts are no longer used because the bind Calcium in the body, which is not good.

SWIM have yet to try DMSO as an aid to sub-lingual ingestion, however after working with it in the lab SWIM would not want to snort it, but SWIM doubts it would burn just be odd.

Yes the carbonate would likely be best. I think this would be an effective way to administer these compounds. If it doesn't cause the sneezing uncomfortable effects this would be great. Tinkering with the pH may even enhance absorption.

hmmm interesting..that would be a really nice way to take it

Cause its gross. I don't like doing it either.