Age 18

Height 5'10"/Weight 155-160 lbs.

Dosage: Various, Methoxetamine or 3-MeO-2-Oxo-PCE; Dissociative/Psychedelic/Anesthetic

Scale: Various

I have been working with Methoxetamine for a few weeks now, this
compound is in the Arylcyclohexylamine family; which houses other friends like
PCP, Ketamine, and 3-MeO-PCP.

After I had tested the material at 5 mg. (insufflated) for
allergies and purity I began work with increasingly larger doses until
I was able to reach a comfortable/insightful dose range.

In my first few trials I insufflated this material, I began
each time after having a few 4.3-5.5% ethanol beers (no special reason
I had done this, it just played out this way). I started out with a
dose of 15 mg. insufflated and added a 10-15 mg. booster after an
hour or so had gone by. The first time I tried this method I stopped
when I had reached 30 mg.

30. mg- This compound exhibits slight sedative/stimulant properties
within the first few minutes of dosing, it acts as a stimulant in the
heart by increasing pulse rate by about 15-20 beats off my normal
resting pulse rate. (This being 65-70 normal and only pushing me up
to 85-90 beats). For me this wasn't an uncomfortable boost in heart
rate. After the compound has absorbed the stimulant properties subside
and you may feel a slight bit sedated, nothing that would induce sleep;
but more a comfortable placid relaxation.(Nothing that would inhibit
movement) After about 15-20 min. the sedation subsides and yields a
small to moderate dissociative feeling, this consist of slight visual
distortion, auras and waves of energy seems to be much more noticeable,
nothing like flowing colors and patterns; just a heightened sense of
awareness. Where this compound really shines is, in its ability to
open the emotional walls of the individual. I was walking with a
friend at the time and conversation was so easy, explaining things
personal and close became just as easy as small-talk. Don't confuse
this with the talkative nature of alcohol; in which one will talk your
ear off and doesn’t know when to stop. This compound allows one to be
fully in control of what you let out in your words, it merely allows
things to flow much easier and cleaner. Thoughts seem to take on an
easy calm nature. Using it in the insufflated manner comes down in
about 2-3 hours after dosing, with about 6-7 hours of a pleasant
afterglow later. I had a slight headache the next morning, but I think
it was just because I hadn't had enough water.

50 mg. - Again I used a similar means of dosing and had a few beers
before hand. I noticed the rush of sedation, if you can call it a rush
and I noticed a slight increase in heart rate. This time I was with a much different
group of individuals, who were also interested in sampling the
compound. After we have had a bit of herbs and allowed the compound to
flow we decided to talk a walk, everyone commented on the ease of
discussion and opening qualities noticed. Another thing that should
be noted is the topic of discussion. I'm sure every psychonaut talks
about life, philosophy, the government and such under the influence,
but not limited to this. One thing I have noticed about MXE is that
it triggers something in the brain that causes the user to want to
talk about these things (meaning of life, what is reality and such).
The people that I was hanging out with during this experiment do not usually
engage in conversation about these topics, but after the doses of MXE
kicked in, it was a very open, upbeat discussion about everything and
anything that is life. As the night winds down I decide to prepare
myself some kava kava, I have a shell and notice it hits me very very
strongly; I have another and I almost feel as if it's too much. I
start to notice how hard it is to breathe easily and how zonkered I
really am! I read quite a bit to keep me awake, and actually do a bit
of purging as it is worrying me. I have read that Ketamine and the
likes increases the amount of GABA in ones brain and that taking
downers on it is a big no-no. (Always research!) I was able to get to
sleep fine and was alright the next day, but still brought me a cause
of concern and worry.

-Oral
I have found that taking MXE Orally is probably the best route of
administration, the pleasant effects stay with you much longer, the
rush from insufflations isn't missed, and the dosage needed to get
strong effects seems to be lowered. Plus I have never noticed nausea.

30 mg.- The come-up wallobed me, I wasn't expecting to get so far with
the small amount, after I had seen how 50 mg. insufflated was. The
sedation was much much more pronounced, and I did sit in my chair
during the onset. Also I had no alcohol beforehand, a clean brain to
go into it with. My girlfriend was over at the time and we started to
discuss some things after the initial sedation had subsided for me. We
spoke on our relationship and I was able to manipulate the opening
properties of the material to my advantage. I am usually very
suppressed in my emotions, and these negatively effect our
relationship at times. We were able to discuss everything that had
been going on and why things were going the way they were, I got very
emotional and much crying was done. Later the material took a larger
view at society ,we discussed problems in the world today, dead
starving children, and war war war everywhere; this led to Pink Floyd
and much more crying. Now don't get me wrong this is an absolutely
beautiful material, it is just this evening lots of things were built
up. The MXE allowed me to release all these emotions and built up
negativity, afterwards I felt thoroughly cleansed; I may not stop all
the suffering in the world but I acknowledge it.(She says I feel
emotional distress and sorrow much more than others and that is why I
hold up all this negativity, but no one should act as a martyr) After the
evening began to wind down, some intercourse was had and was
absolutely amazing, much more mental though than physical pleasure. I
woke up the next day feeling great, just a bit tired.

40 mg. - This time I had another 30 mg. to start and another 10 mg.
booster a bit later. The feelings and effects where much similar to
the last experience, just different setting and a bit sleepy
beforehand. I realize how fun it is to get lost in doing tasks and
just about any activity on MXE, I loved baking some herb cakes with my
girlfriend at 2 a.m. listening to strange itunes reggae, things
just seem right sometimes. What I'd really like to mention about
this occasion is that I had tried to have one 5.3% ethanol beer on the
comedown while we watched a movie. After a few sips I felt overly
GABAtized, to an uncomfortable degree; as if I was on the edge of
passing out. I only managed to drink half of it, and really just
wanted to confirm the earlier theory of MXE releasing extra GABA. This
action must take place later on in the brain though, because having a
few beers before never gave me any troubles at all. The beer was too
much though, I passed out in bed, my girlfriend said I was like a rock
unable to be woken up. I also slept for a good 10-12 hours and still
felt very tired the next day.

*****WARNING be very careful combining downers with MXE, I could of
been lucky because of my small doses of kava and ethanol, be very very
careful******

This material for me is one of the best treats I have sampled in
awhile, very friendly and social, can also be very introspective and
cleansing. If it did not have the addictive properties and could be
used in the safest manner possible I can see this being essential for personal
therapeutic work. I highly recommend it, just be careful we still don't have any adverse effects and on it's pharmacology
and health effects.



Be very safe everyone and do your homework
much much much love and peace from your friend untm

Consumed about 35 mg of this in two installments last Sunday and had a very pleasant day with the GF. It was a very therapeutic experience, and one I look forward to indulging in again. Top substance this

Most defiantly, this is actually quite an old report and I have had many trails now with this compound at doses up to 150 mg. and I have to say I'm amazed. The therapeutic potentials of this compound are absolutely astounding; even a recreational low dose almost always turns into a therapeutic breakthrough with emotionally calming and clearing properties. Like a brain defrag, if you will.

Big fan of MXE.

Seeing that it only became available in September of 2010, though, I am a tad bit wary simply by virtue of how much we don't know. It also acts on a very large variety of areas in the brain. This is why it can be stimulating and sedative, mood elevating, empathogenic... and of course dissociative.

SWIMs main interest in the compound was as a substitute for other dissos, and was happy to find a compound with such glowing reviews that only required a small amount to get effects that required considerably more of his fave disso DXM.

While MXE can certainly take one pretty deep into dissociative territory if one takes enough, the so-called M-Hole is not identical to a K-Hole or a 3rd plateau DXM trip. It's almost too speedy for the seriously deep explorations. The places one goes with it are in constant motion, and do not solidify enough to allow one to do the kind of work that one can with Dexter.

MXE will never replace Dex, but it is far more versatile and user friendly. It has nearly none of the potentially annoying side effects of DXM or even Ketamine. In fact, if anything, it is simply too easy on you. One has to be strong and disciplined not to use it on back to back days. SWIMs unofficial rule is no more than 2x a week... simply because he could see it becoming a daily thing all too easily.

There is a curious mental stimulation that provides an impressive amount of clarity. Unlike any other disso, there is a keen sharpening to the mind space and very wise voice of reason that seems to aid you in your contemplations. Like having a combination of the holy spirit and a wise wizard sitting on your shoulder. SWIM is able to remain very clear with DXM, but this is another level... not maintaining clarity, but increasing it substantially. This also seems to prevent you from letting go into the super high meditative states that Dex is so great at.

On the plus side, MXE does what any good disso does as a launchpad for other entheogens... and it goes with DMT like it was made to do so. In-freaking-credible. It is also inspirational in a very motivational way. Also, a DXM & MXE combo is so damn awesome that SWIM doesn't have words to adequately describe it. A half hit of changa at the peak of a D&M session is like if 7th Heaven moved in with Cloud 9 on Easy Street... with aliens.

On the negative side, MXE can intensify tinnitus to an annoying level at times... especially the next day. Not sure what that is about. It could be the good "spiritual" buzzing in your ears of astral OM... or some serotonin toxicity perhaps. Also, the "afterglow" is endless. And it feels like you just don't ever really come down at all. This compound must have an epic half-life. If you are sensetive to the effects and aware enough, you can notice the shit for a week or more afterwards. (many would not put this into the negative column)

If you do want the effects to go away, SWIM finds that a cup of valerian tea works well enough. He assumes based on this, that benzos in general would work, but has never tested this and will probably never do... he doesn't generally enjoy downers and never has any laying around.

All in all: optimistically cautious, while loving the one armed genius who brought this into the world.

It's great to have some feedback from another DXM user, I myself was using it on and off in high doses for a few years and it is an incredibly deep compound. I agree with you that I cannot dive as deep with MXE as I could with DXM but I enjoy the lack of physical discomfort.

I have tried a few tryptamines with MXE and they go wonderfully together, on the mention of using a benzodiazepine for sleep later I had tried 0.5 mg. of Etizolam on one occasion and I did not notice any adverse effects or uncomfortable respiratory depression. Keep in mind this was after I was well down and benzodiazepine usage is nothing that should be done carelessly or often.

The mention of tinnitus is interesting I have never noticed such the day after MXE use, just perhaps a little dopamine burnt and sleepy.

Thanks for your comments and insight.

-Untm

Here is a thread where I lay down some ideas on how to deal with DXM's physical discomfort effects: Dextromethorphan Hydrobromide (DXM Redux)

The cliff notes version is just to drink some anti-nausea tea and take a bath. Dex in a dark bath is unreal.

*** be careful with this. trying to move around in a dark bathroom on a high level DXM trip is not a good idea. bathrooms are dangerous enough places as it is. if you can't reach your light switch easily, leave a flashlight nearby in a designated spot. dxm can make your environment completely unrecognizable in the dark. ***

As for benzo's I don't recommend them at all. Considering what has been said here about GABA-ergics, it could be dangerous for at least some percentage of people. SWIM has had no issues with valerian, or even taking pure GABA... but he has not tried to do any substantial amounts. GABA can be a neuroprotectant for disso use, but people need to find out if and how much they can use of this amino-acid/neurotransmitter on their own... please use common sense.

As for alcohol & MXE, it seemed that the MXE cancels out a good bit of the ethanol high, and sobers SWIM up. This could just be the clarity in action though.

Yeah I agree, I would only use the benzodiazepine in a low dose and usually I go for other things such as Kava or GABA.

I thoroughly enjoyed reading your DXM thread a few days back actually, I always extract and use freebase with ginger and cannabis for nausea.

Another good thing to help with sleep during dissociative use would be Melatonin, safe, non-toxic, and no interactions to fear.

Melatonin rocks, but it could contribute to serotonin syndrome, if the user were already overstimulated in that department. Afterall, melatonin can be directly converted into serotonin.

Most of the good drugs should not be combined with SSRI substances actually.

Glad you enjoyed the dex thread.

As long as the user is aware and just sticks to the MXE though I highly doubt a serotonin crisis could occur but yes always be on the safe side.