I have had 2 experiences recently on mescaline, and both times i experienced extreme pain in my lower body in the form of leg cramps and tightness. It was really bad in my ass muscles, and for the entirety of the trip it seemed to not go away until i came down and woke up the next morning. My first experience was on 400 mg of mescaline hcl, and after a very weak trip i bumped it up to 800 mg and experienced the same side effects although the trip was more profound but not as strong as i was expecting.

I might add that after doing an extraction i washed the crystals with acetone and redissolved in water to produce crystals that were light tan in color. I found this thread that was very interesting, but i'm wondering if anyone has had similar effects to mine and if there is something else going on that i'm not aware of? Any help is appreciated

I have been thinking about this the past couple days, and i can recall having a thought during my trip that the pain i experienced might be a sign of a chakra blockage. Along with the extreme pain and tightness i remember feeling constipated and the urge to crap but the inability to do so. I have a feeling this might be a sign of my root chakra being blocked but then again it might have just been the mescaline. I am going to experiment again here in a couple weeks and see how it goes.

I use tiger balm when i get muscle aches or cramps, on psychedelics especially. It seems there's many vasodialiating compounds in the oils they put in the balm. Menthol, cassia (cinnamon), etc. I just know it works in a similar way to coffee when i get tension headaches, and the caffeine helps to open up the blood vessels. You could also try caffeine to relieve some of the cramping tension, but know it will make the mescaline more stimulating, as well as potentiating it.

There's a ton of natural compounds like this that would be worth exploring to help enhance trips by reducing some of the negative body load, lemon essential oil, and lemon balm extract are also two handy herbal allies i use when trips become uncomfortable. Lemon essential oil for the nausea, and the lemon balm as a light benzo, it appears it has affects on GABA that help me calm down, and not be so spun out on stimulating phenethylamines, including mescaline.

I also experience constipation on mescaline, its just part of the deal for me, no getting around it, unless you shape your diet before hand to make crapping more easy . Caffeine also helps get my digestive system moving along. I can't take a dump in the morning without my coffee it seems.

Ok, this indicates a few possibilities.

If it from cactus it is unlikely to be pure mescaline, even if it is very pure looking crystal. As for the dose and reported effects, 400mg should result in full effects, 800mg should be very strong.

I have never had any cramp type effects from cactus or extracted alkaloid, also out of thousands of accounts of mescaline those types of effects seem to be almost unheard of. I have heard of cramps from a person stretching or clenching muscles, but that is a result of physical activity and posture.

I would suggest that the alkaloid source, whatever cactus this involved, is not ideal. I would guess that the source is a peruvianus type, because those are often chemically variable and rarely decent sources of pure mescaline. Try doing a similar extraction on some other cactus and see how far it goes. Be careful, 400mg can be strong if it is pure mescaline.


There are reports of weak crystalline extractions and people getting used to them and then having some decent stuff and being blown away by a dose that they thought would not be so strong, so some caution is a good idea because 800mg of weak crystal is not bad, but 800mg of purer mescaline might be a dose that would not be repeated. A lot of people who have taken a gram of the pure stuff once will not do it again.

Then again it is a lot like being inside a huichol yarn painting world. After a high dose the art of peyote and San Pedro using cultures starts to make perfect sense.