I have a friend that is very interested in trying pharmahuasca. I think she is ready for it... but at the same time she is on a lot of medications. Shes on some antidepressants and a few other drugs. Im afraid that the syrian rue wont mix well with her meds, and also just the fact that shes on these meds in the first place makes me wonder if she IS ready...

I know this girl pretty well and was very convinced that in terms of psychadelic experiences she was ready, but I had no idea the meds she was on until I asked her about it in preperation for the pharma experience.

What do you guys think? I would never want to put her in any sort of danger...

I do not recommend mixing spice with pharmaceuticals even vaporized. People have reported odd effects. If she is interested in DMT maybe a low dose?

how about mushrooms? all the tryptamine beauty none of the maoi interaction

my answer would be a firm no to harmalas until she is off the meds at some point.

Could you find out the exact medications?

She takes: wellbutrin xl, celexa, risperdol and klonopin

Hello we. Those drugs are some of the worst ones you could combine with something like syrian rue. It could be very dangerous! So to be clear NO WAY!! I didn't look up the specifics for each drug, but it is common knowledge that anti-depressants and MAOI will lead to something real nasty.. I dont remember the specific name im sure someone does, it is seratonin ****** syndrome.

Not judging you in any way, just givin you the heads up that this is a bad idea.

Another lesson i have learned is it is of extreme importance to be extremely cautious about who you dose. Someone with alot of problems, and taking a lot of meds is a good canidate for a bad freakout IMO. How well do you know this girl??? Please take no offense in this, I am trying to help. I dont know your exact situation, but very few people are in a real position to be handing these medicines out, expecially to someone in distress.

Trust me brother, I learned this lesson the HARD WAY. Now outside of my extremely close circle of a few friends, theres no way ill dose anyone with anything! You just never know dude.

With all that said, good vibes your way brother, and maybe you guys can figure something else out. Peace

Thank you for the response! I don't take offense at all, I'm glad to get the feedback. I know this girl well and know she's a pretty experienced tripper but didnt know about the meds. Now that I know I def won't be giving her the pharma... Especially since it's my first time too.

I'm going to do the pharma bymyself tomorrow in a nice park. One of my friends is going to play sitter an hang out with me. Very excited to see what unfolds.

Thanks again for the response!

Cool.

Sounds cool, about going to do the pharma yourself tomorrow. Good luck good vibes and I hope you have a great initiation with pharmahuasca!

What dose are you taking? and in what forms are your dmt and harmala (rue seeds, extracted harmalas, dmt acetate, dmt freebase etc?)

Good luck brother and have an amazing trip!

3 grams of syrian rue and 150mg of spice.

The ingredients were given to me by a friend so I didnt make it myself. The rue is ground up and reddish brown. The spice crystally and really nice and white.

I have vaporised spice many times but can't wait for the full length experience

Thanks for all the help and good vibes

150mg is a lot to take for the first time. I would set aside at least 20mg so you can A) lower the dosage a bit and B) so that if it does turn out to be a failed experience, you can have some DMT to smoke and hopefully assuming you managed at least MAO inhibition, you can remedy that with smoking a small amount.

I weigh about 175lbs. I figure I'm under 1mg/lb. And I have extra spice to remedy things if things don't work out. My friend that makes it does 130mg and goes to spiritual parties on that dosage. He said 130 is nice and manageable but not the full experience... I trust his judgment and based on our convo we thought 150 will be good.

Like I said it's my first pharma experience, but I'm a pretty seasoned psychedelic explorer and feel pretty confident. I also have a friend sitting it thru with me just in case anything happens.

That's extremely high for a first dosage. Even if your friend handles 130mg, it's fairly well established on the Nexus that personal metabolism, not weight, determines how hard the spice hits you. SWIM goes into hyperspace for a couple of hours at 40mg, so she prefers 30 for her journeys.

Pharma dosages are the most varied of pretty much anything DMT related. Some people can be extremely sensitive to even the 40mg range much less 150mg.

I say go for it. 150 is the lowest I dose for pharma, it's deep without being overwhelming. I started with 150 and lived to tell the tale. Sure, your metabolism may not be like mine (and I'm clocking in at 120 pounds, though I guess that doesn't really mean anything.). Best case scenario you have an awesome time; worst case you get your ass kicked and tough it out.

But you're right to keep your friend off the pharma, she's already on quite the cocktail and I wouldn't give her DMT in any form.

I've been giving out doses of 150 - 200 mg dmt fumerate and 250-300 mg harmalas, I think its important to make sure they get the full experience if they are gonna do it,provided they are in a safe environment of course .

Yea thats what I figure. For better or worse I ok with what ever happens .

I didnt know that it was motabolism more than weight that mattered. I have a pretty fast motabolism, what would this imply about my sensitivity to the pharma?

The harmala dosage plays a pretty big role in it as well. SWIM has only done pharma once, with about 270mg of aya extracted harmalas, and the DMT didn't feel near as strong as when she goes with her normal brews.

She almost always goes with extracted DMT though, since she's so sensitive, another 10mg will be a huge difference for her.

Is there any reason to start so high? Like global suggests, with the DMT, you can just vape to get where you want, as long as you have sufficient harmala action.

This is intriguing me how strong the response is to the 150mg dose. I know that my friend has given 130-170 to people and has never had a problem and as far as I know is usually successful. This friend is not the kind of person to push things with out being very careful, and my senses simply tell me to trust him for better or worse.

I have vaped his spice before with amazing results. He has an tremendous amount of knowledge and respect for the spice and for the type of explorations that we are talking about.

This dose can't be dangerous in itself can it? I mean obviously it may bring about extreme effects that may rock my world, but physically I can't overdose or anything right?

I direct you to DMTripper's First Pharma Experience which was literally just posted. Look at the fifth post in the link for trip report, and you can see for yourself what much less than 130mg can do, and why you should start low. Everyone's different!