I've seen other posts about this saying it doesn't work but has anyone tried pluronic lecithin organogel?
I'm actually not sure if you can buy it without a license but alibaba has some for sale.
Its supposed to be safe for repeated use unlike DMSO.

Its being used to deliver transdermal drugs already and it may even be safe enough for pediatric use.

People say it doesn't work, sure,

but that doesn't change the fact that I tripped my ass off on my way to the grocery store one evening after a careless limo extraction back in the day.

I know it's possible, I haven't cared to explore it further since smoking it and drinking it is so awesome.

how much limo? I have spilled my limo that was saturated with DMT all over my hands before and never felt anything..

It should work in theory if it can be used subliminally then I don't see why not.

Extracting a kilo stoned with no proper lab clothes is about the dose that I absorbed. Probably spilling limo everywhere to be honest. I am not a chemist and don't pretend to be. Don't do what I do. I just chime in whenever someone says transdermal because I definitely know how DMT feels and I will never forget that trip to the grocery store. My pupils were new moons.

I don't think I'll be saturating my skin with any limo anytime soon!
But I am really interested in this ROA.

What was the experience like house?
Lets hear the rundown, I would guess its longer lasting than smoking.
Have you tried subliminal? If so how did it compare?

Also all the people saying it doesn't work, are they pre-dosing with an MAOI?
If DMT is mainly broken down by MAO-A then it is being broken down in the blood so it would make sense that you would have to use ALOT to penetrate the skin and have it saturate your blood enough that MAOI would not be needed.
It would be nice to find sources on cutaneous administration.
If that works I see no problem in taking some harmalas and then rubbing some DMTSO on yourself even though I don't like DMSO I'd much rather check out the PLO since it seems to be less toxic.

I wasnt on harmalas.

I remember leaving my place because I needed something from the store. I began to feel light and get heavy tracers with lights. My hands were vibrating as if they were emitting magnetic energy or something. I was laughing my ass off as my third eye was illuminated as I was walking around I could close my eyes and my innerspace was glowing golden. It was hilarious. I was really surprised it was happening because everyone had always told me it wasn't possible. Then this happens! I was HIGH for probably an hour and I felt amazing all evening. It was really nice because I love DMT and it just randomly snuck its way into my bloodstream and gave me it's divine blessing or whatever the F you want to call it. Too bad limonene is so bad for skin...

I wonder if we could pioneer some kind of therapeutic dimethyltryptamine bath. Talk about bliss...

it cant be broken down in the blood otherwise IV would not work.

Unlike some pharmaceutical MAOI, the Harmalas, alkaloids present in the caapi vine and syrian rue are reversible inhibitors of MAO subtype A....This is what the FAQ says about it and MAO-A is only present in the blood, MAO-B is present in the gut. As far as I know.
which would mean that it is being broken down in the blood, maybe IV just works better because its not going through all of your blood just a small length and doesn't have time to break down?

Oops! My bad Fractal,
I got confused, MAO-B is the one that is present in blood platelets and MAO-A is present in the liver.
So it isn't broken down in the blood so you wouldn't need harmalas.....hmm.

I have tried a small dose with DMSO under my tongue without an maoi. It definatly works.
I'm just concerned about transporting all kinds of stuff directly into my bloodstream, that'S why i did not care to try again. Perhaps very clean fumarate would work ?

Well, yes. All I meant is that it wont be deactivated in the bloodstream so fast that it has no effects. Of course if you ingest harmalas before hand it will take longer to break down.

So it is active sublingually without harmalas? I have wondered about that for a while..

..i would say the DMSO is the carrier here, as most reports of sublingual DMT without some kind of solvent/carrier are inactive...

There was also the time I took some freebase and rubbed my index finger in it. After a while the tip of my finger felt like it was glowing, as if the tiny portion had punctured its way through the veil!

Seems to be the case. I have only tried a small dose though and felt a slight tryptamine buzz (propably 5mg)
I would like to experiment more, but I'm afraid of negative consequences for my health. I also think ,there is one more thread about this, i found after trying it, which raises these health concerns. I felt foolish after being so reckless to try it without really thinking about it.

Yes because there is MAOI enzymes in the brain, this is why the smoked/IV dmt experience is so short, the receptors are flooded with DMT molecules, then quickly metabolized and you are brought back down to a sober state.

So if these enzymes in your brain are inhibited, the experience will last longer, this is basically how changa works.

But if you already on MAOIs, and had an IV experience, it would also last much longer, and at a high dose quite tramatizing i assume

MAOI's are found all over the body, fractal is correct about there only being MAO-B in the blood, Both MAO-B and MAO-A are in the brain, and most of the body.

It strongly depends on how fast the DMT makes it to the brain, and how much gets metabolized on the way there.

I'd love to, but it's pretty risky. I would certainly be trying it if i could ensure my product was absolutely pure.

It would be better doing a substance with a higher potency transdermally, transdermal salvinorin A or transdermal 5-MeO-DMT should work better than transdermal DMT. Also a plaster could be used so someone could have a transdermal salvinorin A patch.

Also does 'gum arabic' (acacia gum) contain psychoactives? I took a caffeine tablet thing with gum arabic as a very prevalent ingredient sublingually (stupid I know) and it made me trip, it might just have been my imagination though.

Why do you guys think it would have to be super pure for transdermal?
When you smoke it its going straight to your lungs and into the bloodstream..
Am I missing somthing?