Has anyone any experience with this neurosteroid? My interest is this: it appears that DHEA's primary activity in the brain is as a sigma-1 agonist, the mysterious brain protein whos only speculated endogenous ligand may be endogenous DMT.

The real question is this: has anyone used dmt in any form while supplementing with DHEA and noticed any different effects positive of negative? And how about interaction with MAOI's?

I have been taking DHEA on and off for many years, but can't really comment on any different effects.

I don't usually use it on weekends, but I'll make a point to try this experiment for you.

I think you're on to something!

Chewed on 25 milligrams of DHEA approximately 30 minutes prior to vaporizing the spice.

Certainly one of the most serene, beautiful and peaceful experiences I have ever had.

So I did it again immediately, just to be sure!

Same, even more profound...

Everything slowed down, became clearer, just amazing.

I do have a head cold, so I can't be sure this did not play a role.

DHEA is mostly produced by the body in the morning, so it should be taken in the morning.

Subsequent attempt with a higher dose, no difference from normal.

Must have been a lower dose first time.

Back to the drawing board...