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Scientific Articles on DMT/Ayahuasca/Psychedelics Options
 
Tsehakla
#61 Posted : 6/3/2011 12:51:44 AM

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5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by a-adrenoceptor antagonists in rats
5-MeO-DMT-induced analgesia is blocked-brjpharm00312-0038.pdf

A Methodology for Studying Various Interpretations of the N,N-dimethyltryptamine-Induced Alternate Reality
paralleldmt.pdf

Ayahuasca Healing Beyond the Amazon: The Globalization of a Traditional Indigenous Entheogenic Practice
Ayahuasca+Healing+Beyond+the+Amazon+-+Preprint+2009.pdf

Ayahuasca Tourism: A Cautionary Tale
Ayahuasca_Tourism.pdf

ฮฒ-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)
b-carboline in rue.pdf

Cult-Hoasca: A Model for Schizophrenia.
cult hoasca.pdf

Entheogens and Existential Intelligence: The Use of Plant Teachers as Cognitive Tools
CJE27-4-tupper.pdf

Hallucinogens as a Discriminative Stimuli: Generalization of DOM to a 5-methoxy-N,N-dimethyltryptamine STIMULUS
HALLUCINOGENS AS A DISCRIMINATIVE STIMULI.pdf

Hyperbolic: Divining Ayahuasca
Divining_Ayahuasca.pdf

Pharmahuasca, Anahuasca and Vinho da Jurema: Human Pharmacology of Oral DMT Plus Harmine
oral dmt plus harmine.pdf

Plants as Teachers Among 4 Mestizo Shamans of Iquitos, Peru
ethnopharmacology_plants_teachers.pdf

Psychedelic Drugs: Steric Factors That Predict Psychotropic Activity
PSYCHEDELIC DRUGS: STERIC FACTORS THAT PREDICT PSYCHOTROPIC ACTIVITY.pdf

Psychological Effects of (S)-Ketamine and N,N-Dimethyltryptamine (DMT): A Double-Blind, Cross-Over Study in Healthy Volunteers
Gouzoulis DMT ket 2005.pdf

Steric and-Electronic Relationships among Some Hallucinogenic Compounds
Steric and-Electronic Relationships among Some Hallucinogenic Compounds.pdf

Suppressive Effect of Mitragynine on the 5-Methoxy-N,N-dimethyltryptamine-Induced Head-Twitch Response in Mice
mitragynine-5meodmt-twitch.pdf

The effect of selective 5-hydroxytryptamine uptake inhibitors on 5-methoxy-N,N-dimethyltryptamine-induced ejaculation in the rat
The effect of selective 5-HT uptake inhibitors on 5-MeO-DMT-induced ejaculation in the rat-brjpharm00345-0020.pdf

The Paradox of 5-Methoxy-N,N-Dimethyltryptamine: An Indoleamine Hallucinogen That Induces Stimulus Control Via 5-HT1A Receptors
5-meo-dmt.5ht1a.paradox.pdf

Thieno[3,2-b]- and Thieno[2,3-b]pyrrole Bioisosteric Analogues of the Hallucinogen and Serotonin Agonist N,N-Dimethyltryptamine
nichols-thienopyrroles.pdf

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Tsehakla
#62 Posted : 6/15/2011 12:26:26 PM

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Attached is a text file containing the full title, authors, abstract, keywords, file name (not always identical to the one used in the post), and the number of the post where the file was uploaded, for all the articles in the posts above this one (#1 to #61) to this date.

If you find any errors or omissions feel free to PM me with the correction.

-Tse
Two things to keep in mind:
1) It is all lies.
2) There is no privacy on the Internet.
 
Entropymancer
#63 Posted : 6/27/2011 6:12:30 PM

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In vivo long-term kinetics of radiolabeled n,n-dimethyltryptamine and tryptamine
http://www.ncbi.nlm.nih.gov/pubmed/21622895


Quote:
Abstract

N,N-dimethyltryptamine (DMT), a strong psychodysleptic drug, has been found in higher plants, shamanic hallucinogenic beverages, and the urine of schizophrenic patients. The aim of this work was to gain better knowledge on the relationship between this drug and hallucinogenic processes by studying DMT behavior in comparison with tryptamine.

METHODS:
(131)I-labeled DMT and tryptamine were injected into rabbits. ฮณ-Camera and biodistribution studies were performed. Brain uptake, plasma clearance, and renal excretion were assessed for each indolealkylamine.

RESULTS:
DMT and tryptamine showed different behavior when brain uptake, residence time, and excretion were compared. Labeled DMT entered the brain 10 s after injection, crossed the blood-brain barrier, and bound to receptors; then it was partially renally excreted. It was detected in urine within 24 h after injection and remained in the brain, even after urine excretion ceased; up to 0.1% of the injected dose was detected at 7 d after injection in the olfactory bulb. In contrast, tryptamine was rapidly taken up in the brain and fully excreted 10 min after injection.

CONCLUSION:
To our knowledge, this is the first demonstration that exogenous DMT remains in the brain for at least 7 d after injection. Although labeled DMT and tryptamine behave as agonists for at least 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine 2C receptor, trace amine-associated receptor, and ฯƒ-1 putative receptor targets, binding to the latter can explain the different behavior of labeled DMT and tryptamine in the brain. The persistence in the brain can be further explained on the basis that DMT and other N,N-dialkyltryptamines are transporter substrates for both the plasma membrane serotonin transporter and the vesicle monoamine transporter 2. Furthermore, storage in vesicles prevents DMT degradation by monoamine oxidase. At high concentrations, DMT is taken up by the serotonin transporter and further stored in vesicles by the vesicle monoamine transporter 2, to be released under appropriate stimuli. Moreover, the (131)I-labeling proved to be a useful tool to perform long-term in vivo studies.
 
Mydriasis
#64 Posted : 7/11/2011 3:41:54 AM
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Any chance someone could grab up:

New aspects of intramolecular hydrogen transfer in some ortho-substituted aryl radicals
Seemon H. Pines, Robert M. Purick, Robert A. Reamer, George Gal
J. Org. Chem., 1978, 43 (7), pp 1337โ€“1342
DOI: 10.1021/jo00401a011
Publication Date: March 1978


and

A simple preparation of phenols from diazonium ions via the generation and oxidation of aryl radicals by copper salts
Theodore Cohen, Albert G. Dietz Jr., Jane R. Miser
J. Org. Chem., 1977, 42 (12), pp 2053โ€“2058
DOI: 10.1021/jo00432a003
Publication Date: June 1977
It's been fun. Thanks for all the wisdom.
 
Infundibulum
#65 Posted : 7/11/2011 1:34:32 PM

Kalt und Heiß, Schwarz und Rot, Kürper und Geist, Liebe und Chaos

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Mydriasis wrote:
Any chance someone could grab up:

New aspects of intramolecular hydrogen transfer in some ortho-substituted aryl radicals
Seemon H. Pines, Robert M. Purick, Robert A. Reamer, George Gal
J. Org. Chem., 1978, 43 (7), pp 1337โ€“1342
DOI: 10.1021/jo00401a011
Publication Date: March 1978


and

A simple preparation of phenols from diazonium ions via the generation and oxidation of aryl radicals by copper salts
Theodore Cohen, Albert G. Dietz Jr., Jane R. Miser
J. Org. Chem., 1977, 42 (12), pp 2053โ€“2058
DOI: 10.1021/jo00432a003
Publication Date: June 1977

There you go!


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Infundibulum
#66 Posted : 7/11/2011 1:37:37 PM

Kalt und Heiß, Schwarz und Rot, Kürper und Geist, Liebe und Chaos

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Entropymancer wrote:
In vivo long-term kinetics of radiolabeled n,n-dimethyltryptamine and tryptamine
http://www.ncbi.nlm.nih.gov/pubmed/21622895


Quote:
Abstract

N,N-dimethyltryptamine (DMT), a strong psychodysleptic drug, has been found in higher plants, shamanic hallucinogenic beverages, and the urine of schizophrenic patients. The aim of this work was to gain better knowledge on the relationship between this drug and hallucinogenic processes by studying DMT behavior in comparison with tryptamine.

METHODS:
(131)I-labeled DMT and tryptamine were injected into rabbits. ฮณ-Camera and biodistribution studies were performed. Brain uptake, plasma clearance, and renal excretion were assessed for each indolealkylamine.

RESULTS:
DMT and tryptamine showed different behavior when brain uptake, residence time, and excretion were compared. Labeled DMT entered the brain 10 s after injection, crossed the blood-brain barrier, and bound to receptors; then it was partially renally excreted. It was detected in urine within 24 h after injection and remained in the brain, even after urine excretion ceased; up to 0.1% of the injected dose was detected at 7 d after injection in the olfactory bulb. In contrast, tryptamine was rapidly taken up in the brain and fully excreted 10 min after injection.

CONCLUSION:
To our knowledge, this is the first demonstration that exogenous DMT remains in the brain for at least 7 d after injection. Although labeled DMT and tryptamine behave as agonists for at least 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine 2C receptor, trace amine-associated receptor, and ฯƒ-1 putative receptor targets, binding to the latter can explain the different behavior of labeled DMT and tryptamine in the brain. The persistence in the brain can be further explained on the basis that DMT and other N,N-dialkyltryptamines are transporter substrates for both the plasma membrane serotonin transporter and the vesicle monoamine transporter 2. Furthermore, storage in vesicles prevents DMT degradation by monoamine oxidase. At high concentrations, DMT is taken up by the serotonin transporter and further stored in vesicles by the vesicle monoamine transporter 2, to be released under appropriate stimuli. Moreover, the (131)I-labeling proved to be a useful tool to perform long-term in vivo studies.

^^
This article is a brilliant find!
I hope to find some time and write a comprehensive review for laymen on that, because its implications are very important and interesting to just pass by unnoticed!



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endlessness
#67 Posted : 7/11/2011 2:36:29 PM

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7 days in the brain??? thats impressive!
 
Infundibulum
#68 Posted : 7/11/2011 4:22:40 PM

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endlessness wrote:
7 days in the brain??? thats impressive!

Yup, that's insane!


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cker
#69 Posted : 7/11/2011 4:39:08 PM

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tripping bunnies....
 
Mydriasis
#70 Posted : 7/12/2011 5:14:06 PM
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Thanks infund!
It's been fun. Thanks for all the wisdom.
 
Citta
#71 Posted : 7/12/2011 8:18:51 PM

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Infundibulum wrote:

^^
This article is a brilliant find!
I hope to find some time and write a comprehensive review for laymen on that, because its implications are very important and interesting to just pass by unnoticed!

Looking forward to the review!
 
SnozzleBerry
#72 Posted : 9/14/2011 5:02:12 PM

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GAS-LIQUID CHROMATOGRAPHIC RETENTION INDICES OF 131s SUBSTANCES
OF TOXICOLOGICAL INTEREST ON SE-30 OR OV-1
STATIONARY PHASE
Wiki โ€ข Attitude โ€ข FAQ
The Nexian โ€ข Nexus Research โ€ข The OHT
In New York, we wrote the legal number on our arms in marker...To call a lawyer if we were arrested.
In Istanbul, People wrote their blood types on their arms. I hear in Egypt, They just write Their names.
ื’ื ื–ื” ื™ืขื‘ื•ืจ
 
Shaolin
#73 Posted : 10/5/2011 7:47:22 PM

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Drying of Organic Solvents: Quantitative Evaluation of the Efficiency of Several Desiccants

D. Bradley G. Williams and Michelle Lawton
Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South Africa
J. Org. Chem., 2010, 75 (24), pp 8351โ€“8354
DOI: 10.1021/jo101589h

http://pubs.acs.org/doi/abs/10.1021/jo101589h
Got GVG ? Mhm. Got DMT ?

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endlessness
#74 Posted : 10/5/2011 8:36:21 PM

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That link doesnt work. Im not sure if you were asking for it or if the link you posted should have the full file..

Anyways, its attached here. Unfortunately it does not talk about the drying of solvents with methods such as used here (magnesium sulphate, etc). The publication is about molecular sieves and silica or alumina. Very interesting nonetheless!

So im attaching:

Desiccant efficiency in solvent drying. A reappraisal byapplication of a novel method for solvent water assay
David R. Burfield, Kim-Her Lee, and Roger H. Smithers
J. Org. Chem., 1977, 42 (18 ), 3060-3065


which does talk about some stuff like calcium chloride, magnesium sulphate, etc
 
endlessness
#75 Posted : 10/19/2011 12:00:38 PM

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Can anybody try to find this paper;

Agurell, S.; Holmstedt, B.; Lindgren, J. E. (1968 ) Alkaloid content of Banisteriopsis rusbyana. Am J Pharm 140:148-151
http://www.ncbi.nlm.nih.gov/pubmed/5698439
 
Shaolin
#76 Posted : 10/19/2011 1:18:56 PM

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endlessness wrote:
That link doesnt work.


Does too Razz It points to the abstract.

Would appreacite if you can access it.
Got GVG ? Mhm. Got DMT ?

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endlessness
#77 Posted : 10/19/2011 1:51:00 PM

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its attached in that post you quoted from me Smile
 
Shaolin
#78 Posted : 10/19/2011 2:04:45 PM

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endlessness wrote:
its attached in that post you quoted from me Smile


Uh-huh.
Got GVG ? Mhm. Got DMT ?

Pandora wrote:
Nexus enjoys cutting edge and ongoing superior programming skills of the owner of this site (The Traveler), including recent switching to the .me domain name.


I'm still, I'm still Jenny from the block

Simon Jester wrote:
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Ignorance of the law does not protect you from prosecution
 
Infundibulum
#79 Posted : 11/12/2011 11:12:52 PM

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As requested by inmotion:

A Character Analysis of the Secondary Products of the Porpidiaceae (Lichenized
Ascomycotina)


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InMotion
#80 Posted : 11/30/2011 12:54:15 AM
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An interesting article on chiral resolutions mentioning a very simply prepared stationary phase.
Thanks shaolin for grabbing this for me Smile
 
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