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vaso and bronchoconstriction. Options
 
polytrip
#1 Posted : 4/14/2010 5:53:58 PM
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Do all of the classic hallucinogen's create vasoconstriction and bronchoconstriction?

I think that they do and that the only difference in this perspective, between them is the degree to wich they do this and maybe the ratio between these side effects.

But i've definately noticed both vasoconstriction and bronchoconstriction very clearly with DMT, shrooms, LSD, peyote and 5-MeO-DMT.

LSH gives a high degree of bronchoconstriction (like LSA) that can give you a feverish sort of feeling like you've just ran a marathon, but also when i'm on mescaline, LSD or other psychedelic's, normally not associated with this effect, The effect of vasoconstriction manifests itself in the tendency to yawn or to sigh deeply or breath more heavily then normal.

The vasoconstriction is the worst with shrooms, to my opinion. I often feel cold finger and toe tops when i'm on shrooms and initially i very often get these 'cold-shivers' from them. The degree to wich they do this differst per shroomtype, indicating that there are other substances except just the psychedelic ones that contribute to this effect as well, but the effects are always present to at least some degree.
 

Good quality Syrian rue (Peganum harmala) for an incredible price!
 
polytrip
#2 Posted : 4/14/2010 6:35:50 PM
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I also think it's just not possible that there would be a classic hallucinogen that doesn't have these side-effects at all. Since all classic hallucinogens act on a selective group of receptors, of wich the 5-ht-2 receptor is the most well known. Some of these receptors have all kind of physically regulatory functions as well, so that acting upon 'psychedelic' receptors without having any physical effect related to these receptors is impossible.
 
imPsimon
#3 Posted : 3/14/2011 10:43:38 PM

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Bronchoconstriction really bothers me a lot with all psychs.
Which is the "best" remedy? Is there one?
Did anyone ever try a long acting asthma inhaler? Seems like they could do wonders...

"What Are the Long-Acting Bronchodilators for Relieving Asthma Symptoms?

The long-acting bronchodilators are used to provide control -- not quick relief -- of asthma. They are used in conjunction with inhaled steroids for long-term control of asthma symptoms. The long-acting bronchodilators last for at least 12 hours. Those containing formoterol begin their action within a few minutes, while those containing salmeterol take up to 45 minutes to begin their action."
 
gibran2
#4 Posted : 3/14/2011 10:55:48 PM

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Surprisingly, vasicine is a powerful broncodilator. So using Syrian rue or rue extacted alkaloids (A/B extraction, not Manske) may provide relief.

Here’s what I said in another post:

gibran2 wrote:
From what I’ve read, vasicine and vasicinone, other than having abortifacient properties (pregnant women should stay far away from these alkaloids), are actually beneficial health-wise:

Quote:
… has been recommended by Ayurvedic physicians for the management of various types of respiratory disorders. It possesses potent bronchodilatory, expectorant, anti-spasmodic and anti-septic properties. It also possesses significant antimicrobial activity against gingival inflammation and pyorrhea. It has also shown Uterine stimulant activity, moderate hypotensive activity and thrombopoeitic activity.

Recent investigations on vasicine showed bronchodilatory activity comparable to theophylline, which is a methylxanthine drug used in therapy for respiratory diseases such as COPD or asthma.


Here’s the source of the quote.

gibran2 is a fictional character. Any resemblance to anyone living or dead is purely coincidental.
 
imPsimon
#5 Posted : 3/14/2011 11:18:29 PM

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gibran2 wrote:
Surprisingly, vasicine is a powerful broncodilator. So using Syrian rue or rue extacted alkaloids (A/B extraction, not Manske) may provide relief.

Here’s what I said in another post:

gibran2 wrote:
From what I’ve read, vasicine and vasicinone, other than having abortifacient properties (pregnant women should stay far away from these alkaloids), are actually beneficial health-wise:

Quote:
… has been recommended by Ayurvedic physicians for the management of various types of respiratory disorders. It possesses potent bronchodilatory, expectorant, anti-spasmodic and anti-septic properties. It also possesses significant antimicrobial activity against gingival inflammation and pyorrhea. It has also shown Uterine stimulant activity, moderate hypotensive activity and thrombopoeitic activity.

Recent investigations on vasicine showed bronchodilatory activity comparable to theophylline, which is a methylxanthine drug used in therapy for respiratory diseases such as COPD or asthma.


Here’s the source of the quote.



That's very interessting! Only "problem" is that it alters the experience.
Found this:
Justicia adhatoda, Malabar Nut or as a herb it's called vasaka, contains vasicine
at 0.5-1% vasicine in dried herb. It's said to have many medicinal properties.

Wiki:

"This shrub has a number of tradicinal medicinal uses. It has been used as an antispasmodic, bronchodilator, and mucolytic agent in asthma and other respiratory conditions. It has oxytocic properties and can be abortifacient."

http://en.wikipedia.org/...Pharmacology_and_Action
http://en.wikipedia.org/wiki/Vasaka

vasaka is sold on ebay capsuled and bottled and is advertised as used for bronchial problems.
I'm gonna give it a go!
 
imPsimon
#6 Posted : 3/14/2011 11:22:28 PM

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Supposedly it helps loosen up the phlegm as well, yay!

Some reading:
http://iglobaljournal.co...1/02/RACHANA-ET-AL-9.pdf
 
Ljosalfar
#7 Posted : 3/15/2011 6:12:28 AM

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imPsimon wrote:
That's very interessting! Only "problem" is that it alters the experience.


Can you elaborate on the difference? I have limited experience and have noticed none. Also, I have read widely regarding rue harmalas and this is the first I've heard of a distinct effect for vasicine.
Thanks,
L
"The first principle is that you must not fool yourself, and you are the easiest person to fool." Richard P. Feynman
 
imPsimon
#8 Posted : 3/15/2011 9:26:49 AM

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Ljosalfar wrote:
imPsimon wrote:
That's very interessting! Only "problem" is that it alters the experience.


Can you elaborate on the difference? I have limited experience and have noticed none. Also, I have read widely regarding rue harmalas and this is the first I've heard of a distinct effect for vasicine.
Thanks,
L


Sorry, I wasn't very clear but gibran2 talked about making an extraction from syrian rue
so my comment was regarding syrian rue which contains harmaline etc.
That's why I think vasicine might be interesting because maybe there's little to no alteration
that comes with the bronchodilation. Thoughts anyone?
Anyway, ordered a can of vasaka last night so in time we'll find out=)
 
imPsimon
#9 Posted : 3/15/2011 9:31:38 AM

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Ljosalfar wrote:
I have limited experience and have noticed none.


What are your thoughts on vasicines bronchodilating effects?
In what form did you ingest it?
What dosage?
 
 
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