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Ideas for turning freebase to salt... Options
 
chrono778
#1 Posted : 3/12/2011 12:39:45 AM

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Ive got what seems to be normal freebase(i acquired from a friend from outa town), I need ideally people from SA(for a better reference as to getting some HCl or the like) that has ideas for turning this into salt. I dont know much of the extraction process or the many forms of spice, but the substance i have is a seemingly soft yellowish crystal form(is this what is called freebase?). Its not soluble in water as i have tried to with a little bit in a spoon, added a small amount of d\water and introduced some some heat which only made the spice gooey and separate from the water like an oil. After reading a bit it sounds like i need an acid to turn it to salt which will make it water soluble. Any ideas hints or suggestions will be greatly appreciated!!!
I Organize in order to Equalize
I Balance Opportunity
I seal the store of death
With the Rhythmic tone of Equality
I am guided by the power of MY OWN POWER DOUBLED!

 

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SnozzleBerry
#2 Posted : 3/12/2011 1:31:03 AM

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I'm going to ignore the somewhat sketchy nature of the opening of your post and simply request that you extract your own in the future...

Now that that's out of the way...sounds like you need to do some research instead of just asking for information

Check the wiki

Please check the wiki

Pretty please, check the wiki before asking basic questions

You can simply dissolve your freebase in vinegar and evaporate the excess vinegar to yield dmt acetate
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Seraph
#3 Posted : 3/12/2011 1:51:32 AM

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chrono778 wrote:
Its not soluble in water as i have tried to with a little bit in a spoon, added a small amount of d\water and introduced some some heat which only made the spice gooey and separate from the water like an oil.


*FACEPALM*, Good luck using that DMT, you'll need it
 
chrono778
#4 Posted : 3/12/2011 3:03:54 AM

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SnozzleBerry wrote:
I'm going to ignore the somewhat sketchy nature of the opening of your post and simply request that you extract your own in the future...


I would love to!! It is something that i would love to and very willing to do! Because mimosa is not indigenous to my country its difficult to get, i cant just hop into the process and get started, it will take sum time, but im patient. So in dew time. I have been researching plants that are found here in SA that has larger amounts of dmt that is extractable to a form thats usable. delosperma cooperii looks promising, cause it is widely attainable in the cape area. I read a bit and found a few people trying it with varying results but none very promising so far. Will look into that a bit more.
The reason for asking is to be certain of course. I have general idea, but i consider a I.V. exploration so its a double check and re check. I take the effects on the body and the mind very seriously. Its easy for me as a n00b to find accounts or posts that i can relate to my situation in many ways and just accept, but after reading these few days its somewhat apparent that there is many ways of extraction and many forms of spice. Maybe i dont understand enough yet, but like i said im patient. I have been waiting 8 years to take an active step towards this wonderful gift.
Thanx for the reply.
InLak'ech
I Organize in order to Equalize
I Balance Opportunity
I seal the store of death
With the Rhythmic tone of Equality
I am guided by the power of MY OWN POWER DOUBLED!

 
SnozzleBerry
#5 Posted : 3/12/2011 3:05:28 AM

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May I ask why you want to start your dmt exploration with IV administration? Why not try vaporization first?
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In Istanbul, People wrote their blood types on their arms. I hear in Egypt, They just write Their names.
גם זה יעבור
 
chrono778
#6 Posted : 3/12/2011 3:40:25 AM

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The spice i was referring too i have smoked with very very very good results!! The friend who did the extraction held the glass pipe and handled the flame, he just instructed when to start inhaling and how long to hold between each hit. With a fair knowledge of smoking varies psychoactive plants like scelethium, salvia and even datura I thought i would be able to effectively control these actions...
Haha. As i started with the first hit i could hardly see his hand and the pipe anymore from the intense visuals that overwhelmed my vision. I can remember him instructing for the second hit and the intensity caused me to already start laying backward to start the journey, but he inclined for a third hit which i cant remember and zzzzzzhoooom i went.
Such beauty instilled into such a small catalyst. I heard my breath echoing through my chest (as if standing in my wind pipe) when i started to become conscious of my body again. My experience was very calming and refreshed my perception(reality) completely. It was very strange to me that when he entered the room again to see if i had a pleasant ex and everything his movements seemed very jerky and fast almost nervous-like, same with another friend that entered a few moments later. It seemed their awareness was scattered. Jumping from one thing to the next in ms. Apart from that it was extreme teaching at its best. thanx
I Organize in order to Equalize
I Balance Opportunity
I seal the store of death
With the Rhythmic tone of Equality
I am guided by the power of MY OWN POWER DOUBLED!

 
chrono778
#7 Posted : 3/12/2011 3:42:10 AM

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SnozzleBerry wrote:
May I ask why you want to start your dmt exploration with IV administration? Why not try vaporization first?


I have a few times.
I Organize in order to Equalize
I Balance Opportunity
I seal the store of death
With the Rhythmic tone of Equality
I am guided by the power of MY OWN POWER DOUBLED!

 
chrono778
#8 Posted : 3/12/2011 5:54:26 AM

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When it comes to reasons for iv i feel that its much more direct and to the point to have the substance(whatever it may be) go directly in your bloodstream where you want it instead of goin through your stomach or lungs. Of course after injection it travels through your lungs etc. This usually can be felt by a gas or vapor gusting out the top of your throat normally in the taste of the product you are injecting!!

I have found that the less time between the first of the substance hitting your brain and the last is important if you want the full effect. The shorter of course if going for the full spectrum of the experience and longer. If you want a softer exp, easing into its effects you might say. Also I want to explore the time it lasts to smoking it, because i have had a few substance injected, i saw that there is always a big difference between the time it lasts and the quality! Besides from my past experiences its clear that my visual response is so great that it becomes difficult to administer myself by vaporizing it.

With IV its a few steps done in complete awareness and putting down followed by letting go. It makes me think that in those few seconds whilst smoking, if not completely used to the experience or whole activity you might feel sum anxiety to your effectiveness and handling everything wile quickly losing grip over the whole process which might have bad implications on the journey. I have witnessed similar things when smoking salvia and the heat involved when packing for yourself(which i know is not recommended.Rolling eyes Laughing haha). Weird example but these things have made me approach consumption of many mind altering substances.

Plus i just like doin it in a manner that relates to the person i am and the doses are much more controllable and easily measured. thank you for the interest SnozzleBerry
I Organize in order to Equalize
I Balance Opportunity
I seal the store of death
With the Rhythmic tone of Equality
I am guided by the power of MY OWN POWER DOUBLED!

 
SnozzleBerry
#9 Posted : 3/12/2011 6:25:23 AM

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You do realize that you're talking about injecting something of unknown purity that some amateur extracted in a kitchen somewhere...does this really sound like a good idea to you? Based on your first question it would seem that you have a limited chem background, making this a very risky proposition.

Additionally, even if you do dose yourself via IV, you've made no mention of having another individual in the room with you (if you had, they could have just lit your pipe for you, alleviating that problem in the vaporizing route) which leads me to wonder if you plan on injecting yourself with dmt, which would add even more risk onto an already significantly risky undertaking. How much faster do you think IV'd DMT will hit you than vaporized DMT? If you're looking for accuracy, imo, you should get a milligram scale and weigh your doses.
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In New York, we wrote the legal number on our arms in marker...To call a lawyer if we were arrested.
In Istanbul, People wrote their blood types on their arms. I hear in Egypt, They just write Their names.
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chrono778
#10 Posted : 3/12/2011 7:37:07 AM

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I have gone through many such risks in the past and still do to some measure today and yes i have limited chem background(High school science). I do understand the dangers involved. i have considered the outcome and the amount of product i have to work with is small. its only to explore first. The friend that did the extraction is been doin and very interested in his work for a few years. if he can get mimosa where he lives and continually for many moons i guess he can orchestrate an decent enough batch.

Anyway. I have succeeded in converting it to water soluble. The amount i used can be compared to 0.03cc in an 1ml insulin fit. roughly the amount of a .22 caliber bullet in volumeLaughing

thumbs up. i do have a sitter of course. just to slap me if hes spidy sense goes wrang...Laughing

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I Organize in order to Equalize
I Balance Opportunity
I seal the store of death
With the Rhythmic tone of Equality
I am guided by the power of MY OWN POWER DOUBLED!

 
chrono778
#11 Posted : 3/12/2011 8:37:36 AM

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It worked!!! I ended up with an 0.10ml of solution which at first i only inj 0.015 of to test the effectiveness of it. which did give a very small physical reaction like sum sensation in my back and my head with very small visual. I then proceeded in taking the whole lot with very nice results!! Not enough to break through but a sure sign that it does what i want and expected. This was all in done with the idea of exploring it. At first everything turn a greenish hew followed by my perception expanding so that every little thing in my field of vision was seen. Almost like zooming out, looking at everything at once whilst its turning and changing shape.

Wat was amazing is the experience enabled me to remember allot of my last break through. Its almost like a blanked slowly folding over you to a point where it sudenly reverts back to where it started repeating slowly with the bright green and yellow jagged lines that cover the minds eye.

No strange ghost pains or any sensations i have connected to impure injections from past iv(not dmt). The trip came on slower than when i smoked it, which i was hoping for. So i could wash the fit and replace the cap place it down before the initial effects took hold.

Everything and more of what i was hoping for!!!
Thank you very much SnozzleBerry. For the concern, info and advice.
Love and Light
I Organize in order to Equalize
I Balance Opportunity
I seal the store of death
With the Rhythmic tone of Equality
I am guided by the power of MY OWN POWER DOUBLED!

 
endlessness
#12 Posted : 3/12/2011 2:30:24 PM

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Im glad nothing bad happened to you, but I def wouldnt recommend dmt IV use, as link above says. I must say the other post made you sound very reckless, and just because it worked so far isnt necessarily a guarantee it will always run smoothly.

Why dont you just get a better smoking method if you're not getting where you want? I can guarantee that with the right technique one can go farther then one can handle, so I why take the IV risks specially in an uncontrolled setting if one can go so far and effectively with vaporizing (for example gvg and torch lighter)? While everyone will decide for themselves, I find weird how you come across as taking risks very lightly, and wonder if you might end up really hurting yourself, which of course can have consequences to also those around you and maybe to this community too. Please be careful!
 
Seraph
#13 Posted : 3/12/2011 2:53:22 PM

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chrono778 wrote:
So i could wash the fit and replace the cap place it down before the initial effects took hold.


WHAT? You managed to do all that before the effects happened, you have made me consider self-IV administration as a possible way of using DMT. Do you think you will always have the time to do all these things before the effects happen because if so then self-IV DMT seems like a good method to me. What salt of DMT did you use? (DMT acetate or DMT citrate, what?)
 
endlessness
#14 Posted : 3/12/2011 3:01:31 PM

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This is exactly what we dont want!

That after reading one post by one person that IV dmt is good, regardless of all the other important reasons why not to, and then people suddenly start considering using IV dmt as a good option and potentially injecting themselves with impurities from kitchen extractions and/or seriously hurting themselves by doing it without a sitter and puncturing themselves/ripping their vines out or something!! Check FAQ link above...
 
SnozzleBerry
#15 Posted : 3/12/2011 3:07:30 PM

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What endlessness said

ALSO!!!!!

THE ONLY FORM OF DMT THAT IS FDA-APPROVED FOR IV ADMINISTRATION IS DMT-FUMARATE

However, the odds of you extracting something close to pure enough to meet FDA standards in your kitchen are relatively low.

Additionally, Chrono, if you didn't clean that yellow spice before banging it, you injected plant fats and oils directly into your bloodstream Shocked
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Seraph
#16 Posted : 3/12/2011 3:13:23 PM

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SnozzleBerry wrote:
What endlessness said

ALSO!!!!!

THE ONLY FORM OF DMT THAT IS FDA-APPROVED FOR IV ADMINISTRATION IS DMT-FUMARATE


Hey, since when did the FDA become the ultimate authority on everything? I'm a European, why should I care about the FDA? Smile If injecting DMT was proven to be safe by the FDA and I think the FDA has probably approved other things for injecting based on different anions. ('CHEMICAL X' hydrochloride) So if it is okay to inject something-hydrochloride and it is okay to inject DMT-something then why would a salt like DMT hydrochloride be bad? Could the combination of DMT and hydrochloride really have problems that does not occur with either the DMT molecule or the hydrochloride anion on their own?

Also if you were to make DMT fumarate you could increase the purity by freebasing it and then converting it to DMT fumarate again, this way anything that got dragged along the first time when the DMT fumarate was made could be removed by freebasing it and then it could be converted back to DMT fumarate.

To inject or not to inject, that is the question?
 
gibran2
#17 Posted : 3/12/2011 3:14:20 PM

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chrono778 wrote:
...I have found that the less time between the first of the substance hitting your brain and the last is important if you want the full effect. The shorter of course if going for the full spectrum of the experience and longer. If you want a softer exp, easing into its effects you might say. Also I want to explore the time it lasts to smoking it, because i have had a few substance injected, i saw that there is always a big difference between the time it lasts and the quality! Besides from my past experiences its clear that my visual response is so great that it becomes difficult to administer myself by vaporizing it.
...

It sounds like you are having some issues with vaporization technique.

When properly using a GVG, it is easily possible to vaporize a full dose in a single inhalation of a second or two. Also, the circulatory route from lungs to brain is shorter than the route from vein to brain, so if you are interested in getting a dose to your brain in as short a time period as possible, I don’t think there is anything better than a GVG and good technique.

When compared to effective rapid vaporization, IV administration has no advantages and numerous disadvantages.
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narmz
#18 Posted : 3/12/2011 4:10:09 PM

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gibran2 wrote:
When compared to effective rapid vaporization, IV administration has no advantages and numerous disadvantages.

I don't know if i would say that exactly, have you ever used the IV or IM ROA?

Advantages could very well include a lower dosage, a longer experience if done IM without the need for MAOI's, a cleaner experience - no lung discomfort. I have yet to do IV or IM so cannot attest to the subjective advantages of the experience itself (there are plenty of experiences online and in Strassman's book). IM administration seems particularly interesting due to the length of the experience and the more gentle come-up.

Disadvantages would include the need for a very very pure product, which is not hard to achieve with the fumarate salt if you have done your research. Here is a page over at the nook that goes over how to clean fumarates, if you plan to IV or IM I suggest doing this tek multiple times on the same material, even if it looks to be completely white. Also disadvantages clearly include stigmas associated with needles, the need to know how to inject properly if you have never done so before, and a general need to be more well prepared and meticulous about your methods.

IV and IM administration of drugs is actually a very safe method of administration if it is done with care.

Here is a thorough run-down of sterile technique for IM or IV administration:
Entheogen Review wrote:
#15 THE ENTHEOGEN REVIEW , POB 19820, SA CRAMENTO , CA 95819-0820, USA
# VOL UME VIIII, NUMBER 1 SPRING / SUMMER 2000
by LION (the artist formerly known as TOAD)

The Entheogen Review neither encourages nor discourages the use of needles—we are aware that this is a personal choice. Nevertheless, there is clearly a stigma attached to the use of needles, even in the minds of those who take illicit drugs via other routes. Some of the reasons for this stigma may be: 1) IV (or IM) use of drugs is a route of administration that can provide a quicker method of action (a “rush”) and shorter effects, which may be more likely to lead to drug addiction; 2) The use of needles for illicit drug administration is primarily associated with heroin, and the negative popular image of “junkies” may present a conscious or unconscious idea in the user’s mind that they have “crossed a line” with their drug use that could lead to a greater likelihood of becoming psychologically addicted; 3) Generally speaking, those drugs used illicitly via injection (cocaine, heroin, ketamine, methamphetamine) seem to actually have a greater likelihood of physical addiction.

The following information should be seen for what it is—the presentation of a method that allows for harm reduction for those people who chose on their own to use needles. Using pure compounds and following correct sterile procedures are paramount to protecting the health of the drug user. Needles are used as a safe and effective method of drug administration in hospitals worldwide. Our hope is that through education, the days of users sucking up toilet-water into a syringe to get their fix might be numbered.

To reduce risk of disease transmission, IV or IM drug users should never share their needles, their works, or a communal pool of “drug water.” Those who feel compelled to re-use needles, need to be instructed on proper disinfection methods: first draw up clean water completely, to remove any excess blood, shake at least 30 seconds to break up blood clots, flush and repeat two more times, dumping the water each time. Then repeat this same procedure three times using pure bleach, and then three more times using pure water again. The plunger must then be removed from the syringe and washed with clean water. More safety information related to proper injection procedures can be found at www.cures-notwars.org/junkie/inject.html WE STRONGLY DISCOURAGE THE REPEATED USE OF NEEDLES OR SHARING NEEDLES, EVEN IF PROPERLY CLEANED.

Sterile, single-use needles (such as those used by diabetics) should not be difficult to come by; they are available in some states over-the-counter, often can be had from veterinary or farm/ranch supply houses, and also by mail order from some companies. As a last resort, those in the unenlightened USA might make a quick trip across the border to pick some up in México, if simple possession of needles is not a crime in the state they plan to re-enter.


This article is intended to educate drug experimenters on the logistics and technique used to prepare a safe, sterile drug solution that is suitable for intramuscular (IM) or intravenous (IV) injection. First and foremost the purity of the drug is paramount. It is extremely important that you know the exact purity of the material you intend to prepare, and preferably have a certificate of analysis or other documentation which guarantees the quality of the compound is greater than 99.8% pure. Hearing about people injecting street-quality materials such as black tar heroin or bathtub methamphetamine
sends shivers down my spine. The traditional spoon cooking method and other techniques such as dry packing are dubious at best. The possible negative consequences from injecting impure or incompletely dissolved drug materials are very serious. Such practices can cause severe irreparable
damage to the heart, veins and arteries, and lungs, not to mention the many other possible complications. It’s also important to have the correct form of the drug that is water soluble and has a relatively balanced pH. The HCl (and other salt) forms of the tryptamines and phenethylamines are typically suitable for injection with a few exceptions. DMT is usually not seen in its salt form on the illicit market since it’s usually smoked. If one had a pure free-base material it would be relatively easy to make a HCl or citrate salt solution for injection, although most of the free-base materials I’ve seen were not pure enough for this purpose. RICK STRASSMAN used the fumarate salt form for his intravenous DMT studies, and ALEXANDER SHULGIN mentions several other salts of DMT such as oxalate and picrate in TIHKAL. If there is any doubt in your mind as to whether your material is pure and in the suitable form for injection then please don’t do it.

The following list of materials is what you will need to make a 30 ml bottle of prepared drug solution from which you can draw upon at your leisure. These items may be procured at a medical supply house and/or a scientific lab supply company. Some of these companies require you to set up a formal business account while others are relatively easy to purchase from as an individual with a credit card. Use common sense and a professional manner when dealing with these companies and it’s usually a “no questions asked” transaction.

-Sterile syringe (a large 50 cc size is helpful for this process) and several
sterile needles.
-30 ml bottle of bacteriostatic 0.9% sodium chloride (saline) solution suitable
for injection.
-Sterile 0.2 µm micro pore filter (25 mm diameter cellulose acetate
membrane, or glass filter membrane).
-Small glass bottle with cap that will hold 30 ml of liquid.
-Rubbing alcohol and cotton ball.
-Drug of choice.

Boil the glass bottle and cap/rubber stopper for 5–10 minutes to clean and disinfect it, then allow to dry. Now its time to determine your target concentration and weigh out the drug material. Say that you have 750 mg of N,N-dipropyltryptamine HCl and you want to make your injection solution 25 mg per ml. Your total weight of 750 mg is divided by 25 mg which equals 30 ml of liquid. You can also do the math backwards starting with the number of ml and mg/ml and multiplying that to find the total weight of drug material needed. 25 mg/ml is the proper ratio for DPT, since making it more concentrated will cause those pesky crystals to come right back out of solution.

Put your 750 mg of DPT HCl in the empty glass bottle. Clean the rubber stopper on the sterile saline solution bottle with rubbing alcohol using the cotton ball. Take your sterile syringe and needle and draw out the 30 ml of the saline solution and place it in the glass bottle. You may need to allow some air back into the sodium chloride bottle to equalize the pressure as you go. Save the empty sterile sodium chloride bottle with rubber membrane intact for putting the completed sterilized solution back in.

Next put the cap or rubber stopper on the glass bottle and shake vigorously until all of the drug material goes into solution. If the material is not dissolving you may gently heat the glass bottle by applying a hot tap water bath on the outside of the bottle. Be careful of building pressure from the heat in your glass bottle, it may cause the cap to pop off and spray your precious elixir all over. Sometimes materials can be very difficult to get into solution, but once you get them in they typically stay in. After the drug has fully dissolved you are now ready filter and sterilize the solution with the filter device. The micron filter will effectively eliminate all bacteria, viruses, and undissolved solids from the solution.

Draw up and fill the syringe with drug solution from the glass bottle and remove the needle. In place of the needle attach the sterile 0.2 µm micro pore filter housing with a twisting motion. It fits into the Luer lock just like a needle. Attach a new sterile needle to the outlet nipple of the micro pore filter. With the outlet and needle pointed upward, gradually apply thumb pressure to the syringe to initiate flow. Continue thumb pressure until all the air in the device is displaced with liquid. Once liquid starts to exit the needle, stop applying pressure and insert the needle into the top of the empty sodium chloride bottle. Now facing the needle downward,
apply continuous pressure and fill the bottle with drug solution. You may need to relieve the air pressure build up in the sodium chloride bottle while you are refilling it. This can be accomplished by inserting a sterile needle into the stopper to serve as a release valve. You will need to repeat the filtering process several times if your syringe holds less than 30ml. Be sure to remove the sterile needle and filter housing before attempting to draw up more unsterile solution from the glass bottle. Attach the old needle (unsterile) that you used the first time when drawing up the unsterile solution from the glass bottle, or just draw it up without a needle. Reattach the sterile needle and filter housing and finish filling the sterile saline bottle. If the filter flow becomes too slow or the resistance excessive then change the filter. Be sure to properly label your new bottle with the name of the material
and the correct concentration per ml.

Everything I post is made up fiction. SWIM represents a character who is not based in or on reality.
 
gibran2
#19 Posted : 3/12/2011 5:11:38 PM

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narmz wrote:
I don't know if i would say that exactly, have you ever used the IV or IM ROA?

Advantages could very well include a lower dosage, a longer experience if done IM without the need for MAOI's, a cleaner experience - no lung discomfort. I have yet to do IV or IM so cannot attest to the subjective advantages of the experience itself (there are plenty of experiences online and in Strassman's book). IM administration seems particularly interesting due to the length of the experience and the more gentle come-up.

Disadvantages would include the need for a very very pure product, which is not hard to achieve with the fumarate salt if you have done your research. Here is a page over at the nook that goes over how to clean fumarates, if you plan to IV or IM I suggest doing this tek multiple times on the same material, even if it looks to be completely white. Also disadvantages clearly include stigmas associated with needles, the need to know how to inject properly if you have never done so before, and a general need to be more well prepared and meticulous about your methods.

IV and IM administration of drugs is actually a very safe method of administration if it is done with care.

The OP was discussing IV specifically, not IM, so let’s put IM advantages aside for this discussion. I’ve never done IV or IM anything , so I’m basing my opinions primarily on what I’ve read – Strassman in particular.

To address some of your points:

I don’t think the dosage differences are significant enough to justify IV over vaporizing. When properly vaporizing, maybe a milligram is lost to condensation, another couple of milligrams lost when exhaling, and maybe a small amount remaining in the vaporizing device. So IV requires a few milligrams less material to get similar effects. From the IV descriptions in Strassman’s study, it seems that the come-up and length of experience is very similar to vaporized.

There is little to no lung discomfort when DMT is properly vaporized. In fact, if it is vaporized slowly and gently in a GVG, it feels like warm air is being inhaled. With proper vaporization of relatively pure DMT, only DMT vapor is inhaled.

The “sterile technique” you quoted is very thorough and obviously necessary to minimize risks, but how many users are going to follow this procedure? And how many are experienced and skilled enough to follow it correctly? There are many opportunities for error, hence disadvantages.

(My sister had a friend who was an IV user of heroin. She died from liver failure due to Hepatitis C.)
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#20 Posted : 3/12/2011 7:13:38 PM

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Having used both the IV and IM route (former for opiates and cocaine,latter for ketamine) I think that the onset of the come-up happens slightly quicker with vaporisation but once it starts the IV route does hit with more power.I also see no reason why if one were to inject DMT IV, if the volume of solution to be injected were sufficiently small then I think it would be perfectly feasible to have time to withdraw the syringe and apply a swb to the puncture site before mayhem ensues.

I also think that if ones DMT had been re-crystallised several times and strict attention is paid to sterile technique including micron-filters,sterile water for injection, proficiency in the technique of self-administration then the risks would be certainly not significantly worse then say injecting a bag of street heroin-an act which is done daily by many many people and is survived more often than not.

Ultimately a torch lighter with an adequately packed vaporgenie and correct technique will do everything the IV route would do but just a second or 2 slower.Unless one is trained in injecting oneself and is proficient at it then vaporisation is definitely the preferable ROA due to its lack of the associated hazards which come from parenteral use.
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