Good article House!

I found the bit about the uncertainty about the affinity/action on the mu opioid receptor very interesting-it certainly feels like a mu agonist in its effect but some other complex mechanism could well be responsible.

thanks for that link house!

Personally, I don't feel the mu.
No nose itching, and my erection still works fine and dandy.
So....

Good points, I haven't had any itching, I've never noticed knob problems on mu's, but maybe that's just me... I do get the warm blanket effect though... and that general sense of comfort and well-being... actually my friend called it an electric duvet and he doesn't have any experience with mu's.. maybe only partial agonism? has the 3meo grouping actually been found to have an mu activity or is that all theory as well? I've done 3meopce also and it has a similar warm blanket effect but also I found it to be quite loopy as well, we did have a laugh on it though.

I'm with Jorkest (thanks for the idea man!).

Eating it was much more pleasant. It's a fun experience and motivates me to create art, but the comedowns seem to leave me feeling cold and a little empty But this always happens and never lasts more than the usual period.

45mg of the stuff in blackcurrant jam on toast after a glass of oj. then another drink afterwords.

Much nicer.

Thanks for posting the article house!.. Very interesting.

Something I learned the hard way yesterday is that you need to be VERY careful with dosage. I've found that if the dose is too high, there can be a very intense mania that comes with it.. I never thought I would be sane again.. and I'm experienced with psychedelics.

Be very careful with dose levels people!.. This stuff can seriously warp your mind/reality.

Curious to know what dose range you find these effects at.

"Be very careful with dose levels people!.. This stuff can seriously warp your mind/reality."

Haha yes, well that's sort of the point, isn't it?

SWIM had a scary experience with MXE the other night. He was out and about with friends, doing his own thing and drinking abit, while his S.O. was out drinking with her friends. They had both taken a small dose of MXE earlier in the day. (15mg for her, 20mg for swim)

She had gotten home from a night of heavy drinking, she called him, and he talked to her and she appeared to be fine. Upon arriving home, SWIM found his S.O. locked in the bathroom unconscious. He jimmied the lock and got in to find her passed out, puke everywhere, leaning over the bowl. She was very pale, her breathing was very abnormal and appeared to stop at times (one time it scared SWIM so bad that he pumped her chest and tapped her face until she breathed again). SWIM had to physically pull her up to her feet, she was limp, but came to after being jostled around, and laid her down in the room with a bucket and watched her breathing.

The next morning SWIM asked her if she had taken anything, like maybe some friend had a funky e-pill she decided to take or something, she said no. SWIM asked her if she had taken anymore MXE after she had called him on the phone, and she said yes, she had taken a 10mg dose sublingually. Her memory of the night seems to have dissolved after this dose was taken.

SWIM is not sure if this is a combination of alcohol and MXE that caused this. A similar, but more dramatic story was found on bluelight here. There seems to be common stories of catatonic states experienced unexpectedly with MXE, so be careful.

SWIM advises against mixing alcohol or any other drug with MXE, and would suggest that MXE may potentially be more dangerous than Ketamine, and suggests folks tread lightly, as this and the other experience linked occurred on very low doses.

This could all be chalked up to just too much heavy drinking on her part, but SWIM thought it was significant enough to warn others just in case.

ive been taking between 15-30mg doses..mostly around 20 though..orally and ive taken it probably 10+ nights and sometimes up to 3 doses a night(usually this is 20mg followed by 15mg or even as low as 10mg redoses)

i havent noticed much of any tolerance build up..and it seems that each time i take it i need less of the stuff..

ive had some amazingly clear insights and have noticed an increase in happiness..as well as a bigger LACK in procrastination..ive been doing things that i should do more often..i feel motivated to organize and clean..my mind has been very clear..and my dreams have been very vivid and insightful AND FUN!!

i think that the higher doses are not nearly as useful..but the lower ones have this very magical quality..but lots of control..thinking about complex ideas is easy and fun...

one thing i DONT like is when i smoke weed with it..it DOES increase the effects..but it makes my heart race..which isnt very nice..so i dont really smoke weed that much with it..

its a very interesting chemical..i havent noticed any problems with my urinary tract..i guess time will tell

I have not yet heard of this new version of ketamine. Its interesting that the effects last longer than regular K.

There has been one occasion that SWIM embarked on a spice journey while under the influence of ketamine. The experience was like nothing he has ever undergone before!

It was amazing!!

To sum it up quickly..... K+DMT = OMG!!!!!!

MXE has brought me several amazing insights, I have unfortunately also experienced this side/abdominal pain but its not really there anymore... I mentioned on another thread that MXE has helped me kick a marijuana habit that I've been unable to shake for 7 years... and for this I'm really grateful, it showed me how much it was ruining my life and it turned the key in my brain that said "never again", it's been a real life saver...unfortunately it's also become a habit not as bad as other drugs, not a daily thing, but it's there. Overall its been incredibly rewarding.

I dosed orally tonight and I'm just realising it's so much stronger.... MXE should be eaten. it's like I've got no tolerance with this ROA... kinda knocking me off my feet as I type. I prefer to use my digestive track to consume drugs because it's an amazing machine-consumption is it's function, but dreamwalkers post reminds me that this drug has been so wrongly linked to ketamine. Ketamine has so little to do with MXE. MXE is like iboga? MXE is like salvia? MXE is like DMT? talking gibberish now, but seriously, all these things are acting upon the human mind and the experience is linked.. MXE feels like a plant teacher?

Small world lbeing I also tried the oral route for the first time last night, it definately seemed a bit stronger and think this will be the way I go from now on. Today I feel like I had a large dose of cappi last night, really does feel like a plant teacher ive never had this deep healing afterglow vibe from man made chems before, well maybe the odd time with mdma but not like this, great stuff!



Sent me into a bit of a panic a few weeks ago after smoking some good hash, brought the effects on big time but also this thumping heart beat, now im careful what I smoke, if one right it can be a great combo but dont do too much weed

Sounds like a great chemical, with a couple of scary reports. The thing about the scary reports is that we don't know what went wrong in their case. Was it some kind of predisposition? Mixing with alcohol? With weed? Until a cause for the catatonic states has been isolated, it seems a bit risky to try this.

MXE is one of the trippiest chemicals with the fewest visuals, it's like you're absorbed in mind at times, the trip inside your head is almost more psychedelic, or on par with the classic psychedelics. It seems to give access to unconscious thought processes more so than any other chemical. Truly interesting chemical for the exploration of mind, and the body high is a whole trip in itself.

Has anyone tried this with the spice yet?

I have. Broke through but I've been afraid to do the full dose, frankly I can past the pre flight anxiety with that one even without MXE, it's a once a year thing for me...but there are reports on BL about it, supposed to be incredible... the two go well together.

Here is some of my experience with MXE combos, all research on top of marijuana vapour (before quitting, updated):

Researched it with MDMA+3.5 cubensis, dosed it during the second half but was still feeling residual MXE effects from the night before, noticed this because the trip was completely different from the onset, was a hyper intense experience, quite amazing, not terribly visual but incredible thoughts/feelings, was quite delusional throughout though, I mean it was an insane trip involving religion and all kinds of craziness, very good though.

AMT + MXE 4/5hrs in was incredible, difficult to describe but basically incredible euphoria, in a party setting, everyone talking about futuristic stuff, kinda made everything very sci-fi. The same night DMT was administered at the end, repeated vapes between several subjects, amazing feeling, goods trips all-round, BUT there was an interesting side effect of this, shortly after the DMT, people became concerned about having too much fun, discussion took a more reflective, contemplative, sombre tone and the wkd was over shortly after.. this kind of effect I've experienced before, and I consider it more of a positive reflection from the trip, it's like, OK you've had enough fun, time to look after yourself and call it a night. I would consider the DMT a trip killer at this level, almost.

Vaped AMT + MXE insuf - awesome again, preferred to eating AMT..no naseau, faster come up, faster come down... from my recent experience I think vaping AMT + eating MXE is the best way to go. No weed with this one. Awesome awesome, awesome.

Marijuana in space cake form - trippy, confusing, took me by surprise, went out to meet friends at a bar and frankly I shouldn't have left the house... glided down the street like the nun from blues brothers.

200mg MDAI + MXE - not bad for me and others, but some have had trouble with this combo, kinda felt to me as if it was going in different directions, but still felt great, had a very open night, strong em-pathogenic qualities. Must've been some dopamine activity here as it caused mild jaw clenching. MXE is probably a DRI.

Kratom + MXE again half way through, only a little bit though - all right, 2 effects overlap but this was not actually enjoyable for me, I felt quite a lot of CNS depression and generally the effects were basic, maybe more MXE would've been better, but it didn't actually feel that safe TBH.

10mg valium + MXE - very nice, more relaxed, less confusion, didn't keep me awake.

30mgCodeine/10mgValium/KavaKava/MXE - small amounts of everything, this was kinda super lovely actually, very laid back, super relaxed as you'd imagine but again, I could've been pushing things very stupidly with this, just posting my experience.


====================

gonna try soon: paneolus, phenazepam, ketamine, I may try 3meoPCE, I did NBOME-Mescaline recently and I think that would be a good one as well. I wouldn't do it with mescaline because mescaline combos have been f'ing disastrous for me, but NBOME-Mescaline has no nausea, a faster come up and lasts on 3hrs... it's like user friendly mescaline. Wanna do 2C's but they dont' come around here too often.

Man, I've never done cappi properly... how are you doing that? drinking it? what dose? I've got to give that a try... would you recommend?