I recently read that DMT causes nausea (when taken orally) because it is a very alkaline substance.

That made me think of adding vinegar to the capsules to increase the acidity but I don't know what effect vinegar might have on DMT, it could likely destroy it for all I know.

Does anyone think it might be a good idea top try?

That will not be any problem. Vinegar is already used in many A/B teks without any apparent harm to the DMT. However, I doubt the minute amount of DMT will cause any nausea because of it's alkalinity, as the large amounts of stomach fluids are highly acidic.

It is also worth noting that many people report acetates and especially fumarates give more immediate effects when taken orally with MAOI. I have also heard some people report nausea when orally ingesting freebase DMT vs. acidified DMT. However, I personally have never experienced this difference, but the difference in come up time is very clear and present.

Happy journeys!!!

Dissolving dmt freebase in a glass of orange or lemon juice should work just as well

Vinegar damages dmt freebase by turning it to the dmt acetate salt. It is a really modest and reversible modification (even desirable at times) that does not affect the molecule's ability to hit your receptors.

I didn't think about orange juice.

I've added some ginger powder to my spice capsules this time, hopefully that will help with the nausea of the DMT. I'm pretty sure it's not the Rue extract.

Thanks.

the nausea is a somatic effect (visceral response) of 5HT3 receptor signaling in the gut, has nothing to do with the form of the molecule itself.

Can anyone describe this in more detail? The signaling is due to DMT activating these receptors? Normally, do these receptors in the gut (intestine, not stomach?) respond to seratonin - if so, what prevents nausea in this case? What is meant by "visceral response"? Is this muscle contraction?
Thanks in advance for any biochem illumination!
L

5HT3 subtypes are in the gut; psilocin, mesc, dmt, and lsd can induce activation of these receptors, resulting in a visceral response (a symptom), of nausea.

ginger contains a compound which antagonizes 5HT3, effectively blocking that response.

Does ginger partially block the psycho-active effects of dmt, etc., or does 5HT3 need to be activated in the brain for these? Are there 5HT3 throughout the body, responsible for "body load"...? If you can recommend a resource for the amateur science enthusiast, I will return to the Nexus next time with better questions!
Thanks,
L

If i'm not mistaken, ginger wouldn't mess with the psychoactivity because that's a response to antagonists of the 5HT2-A receptor. . ?

DMT does interact with the 5HT2-A receptor, but as an agonist, not an antagonist. To make the distinction clear, an agonist both fits into the receptor and activates it, sometimes more eagerly than what the receptor is designed for. an antagonist fits into the receptor, but does not activate it, blocking other chemicals from takings it's place.

Never knew that. Kool.

Congrats on your Voyager rank.

that really depends on the ligand...if it's an allosteric affector, it will not bind the active site.

On some sexy stalking mode are you ?

Thanks for the clarification, my chemistry skills are very...basic.