Many seem to be following popular DMT hearsay, only to eventually have it smashed out of them as they learn more about it. Here's a shortcut.

1: There is no proof that DMT is released in your brain.

2: Many chemists will argue that various conditions needed for the production of DMT in the brain simply are not there.

3: Strassman himself only hinted that DMT may be produced by the pineal gland. It's not even a theory.

4: Joe Rogan lol.

5: ^^^^

Addendum by Rick Strassman

"I did my best in the DMT book to differentiate between what is known, and what I was conjecturing about (based upon what is known), regarding certain aspects of DMT dynamics. However, it's amazing how ineffective my efforts seem to have been. So many people write me, or write elsewhere, about DMT, and the pineal, assuming that the things I conjecture about are true. When I was writing the book, I thought I was clear enough, and repeating myself would have gotten tedious.

"We don't know whether DMT is made in the pineal. I muster a lot of circumstantial evidence supporting a reason to look long and hard at the pineal, but we do not yet know. There are data suggesting urinary DMT rises in psychotic patients when their psychosis is worse. However, we don't know whether DMT rises during dreams, meditation, near-death, death, birth or any other endogenous altered state. To the extent those states resemble those brought on by giving DMT, it certainly makes one wonder if endogenous DMT might be involved, and if it were, it would explain a lot. But we don't know yet. Even if the pineal weren't involved, that would have little overall effect on my theories regarding a role for DMT in endogenous altered states, because we do know that the gene involved in DMT synthesis is present in many organs, particularly lung. If the pineal made DMT, it would tie up a lot of loose ends regarding this enigmatic little organ. But people seem to live pretty normals lives without a pineal gland; for example, when it has had to be removed because of a tumor.

"In both these regards--the pineal-DMT connection, and endogenous DMT dynamics--we ought to know a lot more within the next several years due to the efforts of a research group being led by Steven Barker at Louisiana State University. He, with his grad student Ethan McIlhenny, are developing a new super-assay for DMT, 5-MeO-DMT, bufotenine, and metabolites. This assay will be capable of detecting those compounds much more sensitively than previous generations of assays. They're looking at endogenous levels in awake sober normals, to assess baseline values of these compounds. We should have some data from those samples within a year. They also will be looking at pineal tissue. Once we have some baseline data in normal humans in normal waking consciousness, comparisons can be made between those levels and levels in endogenous altered states, like dreams, near-death, and so on."

So, it's not a fact that DMT is NOT in our heads either???

It's still, "we don't know"?

Many seem to be following popular DMT hearsay, only to eventually have it smashed out of them as they learn more about it. Here's a shortcut.

1: There is no proof that DMT is released in your brain.

2: Many chemists will argue that various conditions needed for the production of DMT in the brain simply are not there.

3: Strassman himself only hinted that DMT may be produced by the pineal gland. It's not even a theory.

4: Joe Rogan lol.

5: ^^^^

Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine
Author: Jacob, Michael S.; Presti, David E.
Abstract: The presence of the potent hallucinogenic psychoactive chemical N,N-dimethyltryptamine (DMT) in the human body has puzzled scientists for decades. Endogenous DMT was investigated in the 1960s and 1970s and it was proposed that DMT was involved in psychosis and schizophrenia. This hypothesis developed from comparisons of the blood and urine of schizophrenic and control subjects. However, much of this research proved inconclusive and conventional thinking has since held that trace levels of DMT, and other endogenous psychoactive tryptamines, are insignificant metabolic byproducts. The recent discovery of a G-protein-coupled, human trace amine receptor has triggered a reappraisal of the role of compounds present in limited concentrations in biological systems. Interestingly enough, DMT and other psychoactive tryptamine hallucinogens elicit a robust response at the trace amine receptor. While it is currently accepted that serotonin 5-HT2A receptors play a pivotal role in the activity of hallucinogenic/ psychedelic compounds, we propose that the effects induced by exogenous DMT administration, especially at low doses, are due in part to activity at the trace amine receptor. Furthermore, we suggest that endogenous DMT interacts with the TA receptor to produce a calm and relaxed mental state, which may suppress, rather than promote, symptoms of psychosis. This hypothesis may help explain the inconsistency in the early analysis of endogenous DMT in humans. Finally, we propose that amphetamine action at the TA receptor may contribute to the calming effects of amphetamine and related drugs, especially at low doses.
URI: http://hdl.handle.net/123456789/381
Date: 2004-10-15

Science 13 February 2009:
Vol. 323 no. 5916 pp. 934-937
DOI: 10.1126/science.1166127

* Report

The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

1. Dominique Fontanilla1,
2. Molly Johannessen2,
3. Abdol R. Hajipour3,
4. Nicholas V. Cozzi1,
5. Meyer B. Jackson2 and
6. Arnold E. Ruoho1,*

+ Author Affiliations

1.
1 Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
2.
2 Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
3.
3 Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, IR Iran.

1. * To whom correspondence should be addressed. E-mail: aeruoho@wisc.edu

Abstract

The sigma-1 receptor is widely distributed in the central nervous system and periphery. Originally mischaracterized as an opioid receptor, the sigma-1 receptor binds a vast number of synthetic compounds but does not bind opioid peptides; it is currently considered an orphan receptor. The sigma-1 receptor pharmacophore includes an alkylamine core, also found in the endogenous compound N,N-dimethyltryptamine (DMT). DMT acts as a hallucinogen, but its receptor target has been unclear. DMT bound to sigma-1 receptors and inhibited voltage-gated sodium ion (Na+) channels in both native cardiac myocytes and heterologous cells that express sigma-1 receptors. DMT induced hypermobility in wild-type mice but not in sigma-1 receptor knockout mice. These biochemical, physiological, and behavioral experiments indicate that DMT is an endogenous agonist for the sigma-1 receptor.

Sci. Signal., 10 March 2009
Vol. 2, Issue 61, p. pe12
[DOI: 10.1126/scisignal.261pe12]
PERSPECTIVES
When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

Tsung-Ping Su*1, Teruo Hayashi1, and D. Bruce Vaupel2

1 Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 333 Cassell Drive, Baltimore, MD 21224, USA.
2 Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 333 Cassell Drive, Baltimore, MD 21224, USA.

Abstract: N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine–associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors.

* Corresponding author. Cellular Pathobiology Section, IRP, NIDA, NIH Suite 3304, 333 Cassell Drive, Baltimore, MD 21224, USA. Telephone: 443-740-2804; fax: 443-740-2142; e-mail: TSU@intra.nida.nih.gov.

Give me one credible scientific source talking about it, otherwise you cant make these claims here. I can give you scientific sources which point otherwise, such as INMT (the key enzyme) not having been found in the pineal gland.

History channel is not a credible source, it airs shows on UFOs, Mayas, Atlantis and the giants, 2012 and whatever else. Please exercise critical thinking, check for other sources when you see something on TV.

"A contemporary investigation, utilizing modern
genetic and structural techniques, has provided a
more detailed analysis of INMT, but does not provide
a complete story. In two studies, Thompson
et al. [35,36], cloned, expressed, localized, and
characterized the activities of rabbit and human
INMT. Using Northern blot analysis, they found rabbit
INMT transcripts expressed heavily in the lung,
moderately in the liver, and weakly in the brain. Human
INMT was expressed in the lung, thyroid, adrenal
gland, heart, muscle, and spinal cord, but not in
the brain. The authors observe high Km values (an
order of magnitude higher than in previous studies
[33,34]) of TYP for recombinant human INMT and
an absence of INMT mRNA transcripts in the brain.
Thus, Thompson et al. conclude that the production
of DMT in humans is not physiologically significant.
Their conclusion places much weight on the significance
of observed Km values for recombinant human
INMT and does not take into account several
additional genetic and enzymatic concerns."

I thought you guys were talking about dmt being made in the brain (and the pineal), not just being present. Sure dmt is present in trace amounts all over in different parts of the body but there's no evidence it is made in the brain, because the necessary enzyme is lacking:


http://www.scribd.com/do...r-Dimethyltryptamine-DMT




I suppose the OP should re-word himself and say that "zero proof DMT is made in your head" instead of "is in your head"

Here it is:

Sci. Signal., 10 March 2009
Vol. 2, Issue 61, p. pe12
[DOI: 10.1126/scisignal.261pe12]
PERSPECTIVES
When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

Tsung-Ping Su*1, Teruo Hayashi1, and D. Bruce Vaupel2

and here's the quote/abstract were they directly refer DMT being found in the human brain....the only point of contention is was it produced in the brain did it cross the blood brain barrier. Have you read the article above? I have not.

"Abstract: N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine–associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors."

DMT can be producedby enzymes in mammalian lung (11) and in rodent brain