In SWIM's limited experience, drinking rue tea separately is best - about 15-20 minutes apart...
Also, she agrees that it is a good idea to drink just rue to become familiar with it.
3.5 g seeds per dose is enough for MAO inhibition and psycho-activity.
Manske extraction is relatively simple and eliminates most of the more toxic alkaloids vasicine and vasicinone present in rue.
She recommends it, especially for women - the Vs mentioned above are abortifacients, apparently.
Be sure to filter well - cotton cloth doesn't clog as much as filter paper.
L
"The first principle is that you must not fool yourself, and you are the easiest person to fool." Richard P. Feynman