Hi, from my experience little brugmansia such as 1:1:2 salvia divinorum plain leaf:brugmansia sanguinea (very strong one): DMT, was very safe. Safe as you don't have the first side effects of tropanes such as dried mouth etc... This shouldn't be a problem if you commit to stay on very low doses. Use it in a tiny pinch with caapi leaves and spice as a 10th of the changa weight admixture. Some brug strains are very powerful compared to others. So always try much lower from batch to batch if you like even low doses (thats the thing when using leaves).
Smell like tea n,n spirit !
Toke the toke, and walk the walk !