SWIM wants to try dissolving spice and harmaline in DMSO, then rubbing it on the skin just over veins of neck, letting it get absorbed directly to the blood and taken to the brain.

EDIT: This stuff seems to damage brain, SWIM decides to forget it all together

And it doesn't work either. DMSO is not that dangerous, do you have a claim for the brain damage thing? AFAIK DMSO is used as a carrier for many transsdermal pharmaceuticals as well as cosmetics.

SWIM and others have also tried the transdermal route via DMSO (you may be able to find more via the search engine) with no success whatsoever.

Interresting.

@ infundibulum:
Can you back up on how this doesn't work? And could you provide details of what transdermal creme was used?
Perhaps some forms of DMT cannot penetrate the skin while others can? I understand there are several forms in which many substances can exist;
Salt-forms and Free-base form are the 2 most well known.
Maybe there are many more forms DMT could be converted into, that are more suitable for transdermal administration?

Perhaps we should look at the chemical stucture and properties of substances known to be very effective at being absorbed through the skin and see if DMT can be converted to a form similair to these substances? For instance it is well known that Scopolamine, the main active ingredient in Nightshade plants, is extremely efficient in absorbing through the skin into the bloodstream.
I am no master in biochemistry, but I would like to know why Scopolamine has that property as opposed to substances that won't absord through the skin. If some forms of DMT share in this property, perhaps then they are suitable for transdermal administration.

If that fails I guess SWIY can allways shove a DMT enema up SWIY's bottom end.
But let's explore the possibilities of transdermal DMT administration. It is most interresting.

Well, it doesn't work because it doesn't work. There were several people who tried it in the past. For SWIM it was freebase dissolved in DMSO, then rubbing it on the inside of arm. He also tried it with oral harmalas. I think others also tried acetate and/or fumarate and eventually if was decided that it simply does not work. It would be nice for someone to find a way to make it work, but I doubt it.

A similar story is with insufflated dmt; it is often coined to be a bad way of taking dmt. One needs a lot, the physical discomfort is really not very pleasant and the experience is barely OK.

Every drug has different pharmacokinetics and pharmacodynamics, this refers to the ways the drug is absorbed, reaches its target organs and then gets metabolised.I doubt that there is a form of dmt (by "form" you must mean some salt, because the freebase form has already tried) that works better transdermally, but I might be wrong. Maybe something like dmt octanoate or dmt benzoate or some other exotic salt work transdermally.

Mind you, transdermal administration is very similar to subcutaneous administration. I have never heard of subcutaneous administration of dmt though. What may be interesting (and it is proven to work) is intraocular administration of dmt, which is a safer alternative to transdermal anyway.

DMSO + DMT sublingualy works. The thing is: Is it safe to take unclean spice this way?

I currently know of two people who have felt effects from spice saturated limonene spilled on their hands and the effects were absolutely not placebo.
Colors change, become brighter and more vivid, mood enhances extremely, light has tracers, pupils dilate, hands vibrate, clarity of thought, extra loud tinnitus, etc.

If anyone has some and wants to experiment that would be nice.

Isn't an excess of limo on the skin a really bad idea?

Yes, d-limo applied to the skin is potentially hazardous; it can cause sensitisation with a resulting contact dermatitis which can be persistent.

Whoops ;]

I just noticed that too much of it (diluted in water!) will dry out my hands and make them burn. Nothing dangerous or life-threatening in small enough quantities, but I wouldn't want to rub large quantities of unadulterated limo all over my body.

While I am *all* for psychedelic massage, I think those Sacred Mirrors images of people without any skin were to be taken figuratively, not literally.

Well to me, it's proof that it works, so there must be other effective carriers/methods.

Try it without any carrier at all. Does your finger start vibrating? This has been noted in the past as well.

/me ponders coconut oil

the sacred mirrors are worth seeing face to face on a high dose of L

Sesame oil. It's used as a carrier oil.

The only thing better than tripping is tripping while smelling like spring rolls!

I've used sesame oil before, it's nice. Apricot and jojoba oils, too.

What about orange oil, that's less refined so probably less hard on the skin? And might smell better than sesame...

D-Limonene is Orange oil

D-limo is obtained by distillation of orange oil, which would make orange oil a bit more natural, but probably not of big interest anyway for this thread...

The problem with transdermal sice is that your skin cant absorb/allow transport of very much at all, most patches are less than 10-20mg. I cited a google book on another transdermal thread but but unless you are covering the entire front of your torso your 50mg of spice will really just stay sitting on your skin. It requires a metric fuckload of skin surface area to work. There are certain oils like emu oil that can make this process more efficient, but how much more no one knows yet.

it would more interesting transdermal tropanes alks that was used bi witches dureing middle age.but must be very carefull with this cream
that seems that cannabis cream would work too but swim never tried

some molecules containing polycyclic structures readily diffuse across the phospholipid bilayer of skin, those will be easier to dose transdermally

Harmalas?