I'm thinking of consuming Pharmahuasca and am looking for some advice... i was going to do .2g of freebase spice and 3g of rue seed(crushed with mortar and pistil) but i herd eating Syrian rue can be quite dangerous and can make one blind etc. Can some one clarify the safety of eating around 3g?? and is 200mg spice a nice strong trip but still sustainable for a first timer??

200mg of spice? Start lower maybe 50-75mg. You can always take more maoi/spice as a booster but you can't 'undose' that 200mg of DMT if it becomes overwhelming. Don't eat the seeds, perform an extraction of them to get harmine/harmaline alks or make a tea from it. Whatever you do don't eat the seeds.

Eating whole seeds is healthier than crushed seeds, but requires a larger dose. Also why don't you do an extraction? It's very easy and fun. but if you don't want to do, You can do one of these:
1- Eat a larger dose of whole seeds.
2- Make a tea with WHOLE seeds and drink. (requires an smaller dose than #1)

And regarding spice, do not take the freebase!!! that would cause extreme discomfort and vomiting. always take the spice in salt form.

I don't know why people are saying it's bad to eat Syrian Rue seeds. I mean, it probably isn't good, but not horrible in small amounts. I've never heard of rue being associated with blindness or vision. Syrian Rue has some other alkaloids in it (vasicine and vasicinone) that cause uterine contractions and can cause premature birth, but you shouldn't be taking pharma if you're pregnant anyway. Here's some more on these alkaloids http://en.wikipedia.org/wiki/Justicia_adhatoda Making a tea will extract all the alkaloids from rue anyway. You can isolate the harmalas with a manske, but if you just boil the tea, you'll get all the alkaloids including non psychoactive ones, and whatever else is in the rue that you don't want.

That said 200mg of spice is probably way too damn much. If you haven't taken it before, you do not know what you are dealing with. You know not what you say when you think of taking 200mg. 50mg is a very big dose for me.

Thanks guys
you were all very helpful.
I ended up just eating the rue seed crushed up with 100mg of spice, and about 15 min later had another 100mg of spice because it was having little effect.
the experience ended up being very strange and unexpected, like some kind of amazing shroomy trip, although i felt sort of stable and at no point was i out of my body and in the field of hyperspace which i almost always am when i smoke changer, not sure about being there for 3 hours anyway though.

I'm gonna do this again and again and again until i get it just right!!

What's this "Manske" stuff everyone is talking about? I looked in the wiki but didn't find anything.