SWIM doesn't feel 3 seeds by themselves but it add something to the experience.
If your friend wants to feel something he can crush some of them and smoke them.
Smoking is a "safe" way and fastest to be felt. So he will know where about is the threshold experience.

SWIM uses scopolamine, in the form of Datura inoxia seeds, which contains nearly pure scopolamine. It’s one of the best cleanest sources of scopolamine there is.

He has a lot of experience with it in pharmaceutically active doses, but has never taken a dose to cause delirium.

As a sea sickness medicine, Datura inoxia seeds are very effective. At the dose used, there are no mental affects at all.

These plants are only scary for those who take delirium causing overdoses. The CIA has used scopolamine as a “truth serum” in extremely high dangerous doses. The “zombie” effects scopolamine can produce require a near overdose to achieve. Scopolamine is very safe in standard pharmaceutically active doses, such as 100-1500 micrograms. It’s doses beyond that which are needed for mental effects. About 10,000 micrograms can kill you, and you need just under that to experience mental effects from it. So it’s very dangerous to use for those purposes. It’s best to use scopolamine at doses of 100-800 micrograms only.

thx

how many seeds of d.inoxia would you say, is a safe amount for potentiating other chemicals, and what would you say is the threshold dose for delirium, and what would you say is the threshold to a toxic dose? just out of curiosity.

The main alkaloid in Datura inoxia seeds it scopolamine. The alkaloid makeup is nearly 97% scopolamine. So it's very similar to taking pure scopolamine. The only difference really is that the potency varies from seed to seed.

The average seed contains about 0.4% scopolamine. This data below is based on an average seed size of average potency.

1 seed would weigh about 10 mg and contain about 40 micrograms of scopolamine.

10 seeds would weigh about 100 mg and contain about 400 micrograms of scopolamine.

20 seeds would weigh about 200 mg and contain about 800 micrograms of scopolamine.

25 seeds would weigh about 250 mg and contain about 1000 micrograms of scopolamine.

37.5 seeds would weigh about 375 mg and contain about 1500 micrograms of scopolamine.

250 seeds would weigh about 2500 mg and contain about 10,000 micrograms of scopolamine.

The adult scopolamine dose needed for medicinal effects lies between 100 and 1000 micrograms.

The adult scopolamine dose needed for mental intoxication lies between 1000 and 1500 micrograms.

The adult scopolamine dose needed for delirium lies between 1500 and 10,000 micrograms.

The adult scopolamine dose needed to end your life is about 10,000 micrograms or more. But it may be less in some people.

Doctors routinely prescribe scopolamine for many things in the dosage range of 400-800 micrograms. 1500 micrograms is considered the maximum safe dose of scopolamine. 10,000 micrograms can be lethal. Anything below 400 micrograms (10 seeds) is extremely safe and effective for boosting the effects of other psychedelics. A larger dose is not needed.

You should always assume you have super potent seeds and that you are extra sensitive to the effects of scopolamine. Those figure above are average figures. Some seeds are super potent and extra large. Dosing by seed count is not wise. Doses should be weighed in milligrams.

thanks, i feel like you should that post should be forwarded to erowid... very thorough, thanks!

What an excellent chart, very useful. Thank you for sharing 69ron. You never know, it could save a life one day. Even if not, it's useful information none the less.

Peace,

Macre.

From “The Encyclopedia of Psychoactive Plants” by Christian Ratsch (refering to D. innoxia):

“For smoking, up to four leaves is regarded as an appropriate dosage for eliciting aphrodesiac effects. Consuming the plant in this manner effectively rules out the possibility of overdose. Tea from the leaves must be dosed with care. As little as one leaf can be sufficient to induce profound hallucinations. Because alkaloid concentrations can vary considerably and because individuals react quite differently to tropane alkaloids, detailed information about dosages is rarely provided. Thirty to forty seeds is regarded as a potent visionary or hallucinogenic dosage. However as few as ten seeds can lead to profound perceptual changes.”

Source