I am one of the people that think the masses DO need waking up.

We have enjoyed freedom fought for and won by a generation before us who were turned on in the 1960s and changed society for the better in many ways. However, as that generation grows older and dies, liberties are being eroded again by Western governments. The price of freedom is eternal vigilance, but the youth of today are generally apathetic selfish consumers. Society needs psychedelics again to reawaken vigilance to protect freedom and promote empathy.

I don't know what psychedelic would be best. Maybe ayawaska/DMT or mescaline would be better, or maybe they could make people too passive to struggle for change. Weed is not enough. LSD is the one with a proven track record.

Yeah, another cultural revolution would be fun.
But i don't see it happening very soon.

We in the west are just kinda stuck. No psychedelic in the world is gonna change that.

I don't see why it couldn't happen if an empathy-giving psychedelic become popular on the party circuit. I presume that's what happened with LSD in the 60s. People took it to have fun, and enough people ended up having their eyes opened in the process.

Ketamine is awful, yet people take it at parties. I'm sure these types would lap mescaline up. Perhaps in an anti-nausea combo. If mescaline use exploded, would it bring change? Does it promote empathy and awareness as much as LSD? Perhaps mescaline would then open people's minds to ayawaska/DMT, and if that happened then I'm sure we'd see positive effects.

People are wary of LSD because of bad trips, but seem to warm to mescaline because it has similarities with MDMA. I'm not sure if LSD would ever become popular again given its reputation outside of hippydom. Is there another psychedelic, maybe an RC, capable of capturing the imagination of the masses and catalysing change at the same time?

I think the problems with ecstacy were the comedown and it didn't really make people think like a psychedelic does. So the 'second summer of love' changed little compared to the first. A third summer of love, with mescaline... would that be more positive?

The biggest problem with LSD is that RCs get sold as it. Would this happen if mescaline took off too? Would dealers just sell RCs as mescaline? Is a mescaline boom economically unfeasible? Perhaps it would be a good thing in some way if a law blanket-banned all RCs, because maybe inferior RCs would no longer be passed off as entheogens.

Or perhaps real LSD and mescaline could be distributed by a new Brotherhood of Eternal Love to usher in this new wave? These people would have to get their stuff onto all party scenes, not just the hippy scene where everyone already knows about entheogens anyway. Incidentally, the retro/creative scene seems to be turning to the 60s at the moment... moccasins etc are appearing.

I'm just interested in this hypothetically, I'm not on a mission, though I do wish for something like this to happen and break through the cynical apathy. The world lacks optimism at the moment. Climate change has much to do with it I think... perhaps there is an underlying crippling concern that civilisation as we know it is going to crumble within our lifetimes?

The dosage needed for mescaline is incredibly high compared to next to anything. This makes it way harder to produce the quantity needed compared to LSD, seeing how incredibly many cacti one would have to grow to get a few million doses (a few thousand doses would not change anything). I really believe that mescaline is just perfect for a "third summer of love", but I can't see that happen anytime soon. Unless someone map the genetics of mescaline containing cacti and tamper with the genetics... Or perhaps use modified bacteria to grow mescaline? I am sure it is possible if enough resources is used to attain that goal.

Is synthetic mescaline not possible? Or is there an alternative suitable RC? I'm just not hopeful of LSD capturing the imagination again... although I don't think I've ever had real LSD so I wouldn't know.

TMA-2 (and the rest of the TMA series) have similar effects to mescaline and have actually been sold as "synthetic mescaline". Compared to mescaline they have incredible low dosage ranges, for TMA-2 less than 50 mg is sufficient. I feel stupid for not thinking about this when I wrote my last post...

why is ketamine "awful"?

I am one of the people that think the masses DO need waking up.

We have enjoyed freedom fought for and won by a generation before us who were turned on in the 1960s and changed society for the better in many ways. However, as that generation grows older and dies, liberties are being eroded again by Western governments. The price of freedom is eternal vigilance, but the youth of today are generally apathetic selfish consumers. Society needs psychedelics again to reawaken vigilance to protect freedom and promote empathy.

Yeah, another cultural revolution would be fun.
But i don't see it happening very soon.

We in the west are just kinda stuck. No psychedelic in the world is gonna change that.

NMDA antagonists like ketamine and PCP may be interesting if that is your idea of fun, but they for sure will not change the world. For a summer of love, we need a substance that induces love. Only 5HT agonists and serotonin releasers have the possibility to do that in large scales. Please just leave it at that.

Aren't 2c-b's and 2c-E's similar to mescaline?

A) Genetically modify or perform extensive selective breeding in order to create super-high yielding Trichocereus cacti.
B) Create bacteria that produce mescaline.
C) Use one of the TMAs or other mescaline analogs.
D) Find a good combination of two substances, one that acts as a serotonin releasing agent without causing hangover, and a good psychedelic. This is virtually impossible to achieve if one wants it to be non-toxic.

This leaves me with the fact of the matter that the TMAs or other synthetic mescaline analogues are the only real possibilities here.