great articles
gives me some ideas for hplc analysis of dmt content in plant materials, in vitro.
I noticed the proposed mechanisms for dreams/sleep, there were a few errors in that paper. the author mentions that "melatonin, like serotonin, is primarily produced in the pineal gland". while melatonin certainly is, serotonin is actually made primarily in the epithelial cells of the gut. second, the proposed metabolic pathway for the synthesis of 5-MeO-DMT shows a single enzyme catalyzing the reaction from 5HT -> 5-MeO-DMT (5-HIOMT). this is impossible, because a second enzyme (INMT) would need to methylate the terminal amine group...twice. the author suggests this occurs within the pineal itself, however there is no evidence that INMT is expressed in the pineal gland.
"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck