Hi all,
I posted this in the Scientific Articles on DMT/Ayahuasca section but it seemed a bit buried. I moved it here since it is an interesting recent finding about the metabolism of 5-meo. The original research paper can still be found in the Articles section.
"Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-Methoxy-N,N-dimethyltryptamine Metabolism and Pharmacokinetics"
This is a very fresh paper on the metabolism of 5-meo dmt to bufotenine
in vivo which is augmented in the presence of MAOIs. 5-meo-dmt is subjected to two types of metabolism. The first and known one is its deactivation by deamination from MAO enzymes. The second type of metabolism that emerges from previous work of teh same group is its O-demethylation by the cytochrome P450 2D6 to produce bufotenine.
This paper describes that in
in vitro assays of human liver cells the presence of harmaline or pargyline (another MAOI) not only stops the deaminating deactivation (the reaction MAOs are responsible for) of 5-meo dmt but also causes rapid formation of bufotenine from 5-meo dmt via the cytochrome P450 2D6.
The authors also describe in detail some very elegant
in vivo experiments where mice were intraperitoneally injected with 5-meo-dmt. They used 2 types of mice; standard mice and mutant mice that carry the human cytochrome P450 2D6 instead of their mouse one. It appears that the human cytochrome P450 2D6 is 60% better at converting 5-meo-dmt to bufotenine. When either mice were injected intraperitoneally with harmaline prior to the 5-meo, the majority of the 5-meo was converted to bufotenine.
This paper has very important implications for the different ingestion methods of 5-meo. When one smokes based 5-meo, he experiences the 5-meo in the brain. But with sublingual or oral 5-meo, one allows for slower absorption and chance to pass from liver metabolism and bufo formation prior to entering the brain. Sublingual administration is comparable (in effectiveness and absorption duration) to the intraperinoneal administration the mice in the study were subjected to.
The above is important especially when one uses chaliponga for ayahuasca or tries 5-meo with MAOIs. Has anyone tried sublingual 5-meo in the presence of MAOI here in the Nexus? I remember 69ron mentioning that for SWIM sublingual 5-meo is like a low dosage for lsd.
Has anyone tried 5-meo in "other than smoked" route and experienced bufo-like visuals or (for all purposes) any visuals at all?
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