I wonder if anyone has any insight in combining LSD with MAOI.
Primarily if anyone has any experience in combining it with something like St. Johns Wart.

H. perforatum herb has shown some very weak MAO- and COMT- inhibiting properties, as well as weakly inhibiting serotonin and norepinephrine re-uptake, but the full mechanism of action is yet to be shown, and is clearly a synergistic one between the various compounds present. It has been suggested that the MAOI effect would be due to an unidentified xanthone component (Bruneton 1995; Perovic & Muller 1995; Raffa 1998; Suzuki et al. 1984). The herb also induces cytochrome P450 3A4 and 3A5 activity, and has been shown to potently inhibit cytochrome P450 isoenzymes other than the types mentioned above, with extended use (Coxeter et al. 2003; Fugh- Berman 2000; http://www.dml.georgetown.edu/depts/pharmacology/ clinlist.html). This herb usually must be taken daily for several weeks to become fully effective (Katzenstein 1998; pers. comm.), and should not be combined with MAOIs or serotonin re-uptake inhibitors, as symptoms of serotonin syndrome may result (Fugh-Berman 2000). Antidepressants which have shown interactions with St. John’s wort include sertraline, nefazodone, fluoxetine, paroxetine and amitriptyline. Some studies suggest that St. John’s wort may interfere with the activities of some antiarrhythmic- mic [digoxin], antiretroviral [indinavir], immunosuppressant [cyclosporin, tacrolimus], oral contraceptive and anticoagulant drugs. However, more evidence is needed to determine the extent of these interactions in humans (Coxeter et al. 2003).