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hey I'm going to chime in here-- is THH a strong enough MAOI to use for pharma?

I've seen sort of varied accounts on whether or not it would serve as such

No it definitely isn't - you need to have a good chunk of Harmine too IME. I am not a huge fan of Harmaline (especially the ataxia) but I think it's the strongest MAOI of the three so I always add a little bit for pharma. Like ~5% little.

THH is a weak MAOI, and the varied account are to take with a grain of salt, given, a good proportions of " THH " may not be THH at all or not only THH.. We've seen in analysis thread THH mixed with other harmines, or even no THH at all but harmine and some other tryptamines traces in some samples...
Now I'm not expert on THH only pharmahuasca, and level of MAOI varies within individuals ... some people claims to use passionflower ( which isn't THH but has other weak harmalas such as harmalol ) to activate, while I only used it to boost and combine effects with other tryptamines of lysergamide rather than n,n DMT.
But if you have enough THH you can try out for pharmahuasca or also a good start is dose like 150mg THH together with Harmine and harmaline in lower proportion which would give a good inhibitoin and effect by larger spectrum, you can also use THH and harmine only, as seen in caapi vines only brew.

My plan is Changa with Harmine/harmaline/THH and another batch with Harmine/THH. later maybe Harmaline/THH.

I want to experiment with different proportions of harmalas and see how they affect the trip.
So far I only tried Syrian Rue extracted harmalas (so Harmine/Harmaline)

My experiences so far are not extensive, nor do I have the nerve to trip every week, making the process lengthy,
which is why I'd love to interact with the forum more directly

I've seen people share this POV about harmaline a lot, hence my idea of mimicking the harmala content of caapi leaves instead of using full spectrum syrian rue extract again.

as far as THH effects are concerned I heard it makes things clearer and changes the colour hue of the visuals.

I tried it on its own in HCL form and it felt much more focused, which feels like a nice addition to the trip in itself

thanks!

Since we're on this topic. I'd like to ask something about what "weak" means for an MAOI when mixed with DMT.

Is the strength of the MAOI contingent on increasing the duration of an ayahuasca experience? Or is it more contingent on how intense the psychedelic experience is? Or both?

For instance, if I ingested a weak concoction of THH and then ingested DMT 30 minutes later. Would I have a solid trip that lasted only 2 hours? Or would I have a very subtle trip that lasted 6 hours?

Very curious as I will most likely start experimenting with recipes come summer. For now, I'm still researching the realm of freebase DMT, and soon after will be hopping on the mescaline extraction train.

In an effort to not highjack this thread, someone please feel free to drop a link and point me in the right direction. I couldn't find anything on the wiki.

Both in case of harmine and harmaline, THH only increases strength and apparently makes visuals more clear and more neon-green-purple (according to a fellow experimenter)

so most likely you would have a stronger experience with THH but not longer.
harmaline is the strongest harmala but also the most sedating.

are you talking about oral harmalas and vaped dmt? or both oral

From everything that I can gather, it appears that THH has practically zero efficacy as a MAOI for activation of oral DMT. You are making changa, of course, which makes things a bit different. We do know that harmine/harmaline are more potent when smoked than via the oral route. If this same bioavailability effect applies with THH we can expect that THH in changa would provide the same qualitative nuances as it is said to have in ayahuasca.

The major known pharmacological action of THH at present is as a monoamine reuptake inhibitor, as per Dennis McKenna's (et al) research in recent years.

One more thing, about it being changa, is that there is a possibility that pyrolytic dehydrogenation of THH might occur, transforming it into harmine. That would be something of a waste of effort, perhaps.

I'm awaiting analysis on a putative THH sample but if that is what it is then I can recommend sublingual dosing with this one as my material has a rapid onset even at low doses via that route. FWIW, the flavour is noticeably different from that of harm(al)ine, being much less bitter and more 'chemical'. The subjective effect can be summarised as 'clarity' even when taken alone.

I was talking about oral harmalas and oral dmt, but I'd be interested in oral harmalas and vaped dmt as well. I've never experimented with either.