murklan wrote:I have some ideas on what is happening but it's not so much of the pharmacology. I suspect that after long time use of inhaled/vaped DMT my lungs do not absorb the molecules as before. This and that the mind/receptors are gotten used to it. The latest mushrooms trips has not been visual either (some stronger colors and light sensitivity) but 200 μg LSD made me experience them again.. (but not so strong).
Glad of any thoughts around this
I'm experiencing the excact same issue and don't think your ROA theory is the reason.
I suspect it could have something to do with 5HT2-A receptor de-sensitisation (and/or more complex bio-chemical adaptions). The mechanisms of action besides the knowledge that DMT acts on 5HT2-A receptors are not yet understood.
I have taken DMT daily for over 2 months via IM (intra-muscular injection).
In the beginning I needed 32mg, later 45mg-60mg and while 45mgs gave me strong visuals in the beginning it is just a mellow experience without visuals today.
So my conclusion: There indeed IS a tolerance building with DMT especially when used DAILY or very frequently.
I sincerely hope that the old magic can be restored through a longer break of consumption.Even when I dosed higher in the past days - up to 100mg - while the experience itself could be harsh and strong on my energy-body and nervous system - there wasn't this kind of "3D Hyperspace Visual WOW Scenario" I had in my first DMT experiences.
I also made the observation that several DMT IM sessions (lasting about 30minutes) in a row led to a decrease in effect intensity. The first session was always the best and the following sessions were rather mellow and needed higher dosing.
So there seems to be a short-term tolerance and a long-term tolerance.I initially wanted to write an own thread "How I healed myself from Post-Covid Fatigue - A journey of healing the soul through catharsis and mind expansion and observations on my path". Maybe I'll do that in the future.
All I can say that I suffered severe post-viral fatigue after a covid infection in june and I figured that one single simple 30minute DMT IM experience could get 100% rid of the fatigue for the day.
So I made it a daily morning ritual, a daily 30 minute morning DMT session/meditation.
Through the daily "energetic cleansing process" of my energy-body I got so much energy, inspiration and feelings of lightness out of it that I not only cured my post-covid fatigue but it also completely enhanced my life and mood to a state of high energy vibration, confidence and stamina I had not felt ever in my life.
I felt like I had changed myself and my life for ever through this intense period of daily ceremony. I did much spiritual practice and studying in that time also. It was perfect for integration. On some days I even did three or four sessions.
Eventually the very pronounced effects and benefits on my life faded. Also the anti-depressent effects faded. I hoped for a long time effect on my mood and drive because of my "hard tryptamine work / soul cleansing". I thought and hoped the benefits of my newly achieved energy level might stay for ever even without doing DMT daily.
But somehow the sessions became more and more mellow. The benefits of doing the blessed Spirit Molecule faded.
I'm not doing it daily anymore, stopped for days, a week and now two weeks. Have yet to test if a normal dose which used to be visual before will get visual again.
When I dosed very high, up to 100mg, I also had the feeling that it did not really deepen the trip but that my nervous system was just overwhelmed. It did not feel very healthy, it just felt like I have taken too much, it did not deepen the trip, it just made it more harsh and yeah -
maybe like "burning through the fine energy-system and its electric and microtubial circuits"?If that's the case I hope that the potential "damage" or "change" (if its not a normal time dependet and reversal tolerance) will be healed by the body. The body is a master healer so I have high hopes.
Still I must admit that my first DMT experiences were much more colorful and spacier than the latter ones...
I never did the DMT IM experiences with Harmalas / MAO-A inhibition as I have a rare disease called MCAS (mast cell activation syndrome) and tryptamines were a trigger for my mast cells (leading to allergic reactions like skin stinging all over my body). I need to take anti-histaminics and also have to inhibit COX (prostaglandines) and LOX (leukotrienes) to tolerate DMT without any issues.
My wide spectrum of health problems due to a disease are also the reason why I'm doing DMT via IM ROA and why vaping or oral are not an option for me. I'm working myself in the field of regenerative medicine and prepare sterile solutions regularly. So I kindly ask the readers of the forum to not criticise or discuss my ROA in a negative way here. I'm just saying this because I have seen many prejudices and untruths in other threads by some ill-informed injection-phobics. Doing DMT via IM turned out to be the most supreme, clean and easy ROA in my case.
In the last few days the wish has arisen to try Harmalas again to achieve a deep, balanced and well modulated experience again and the thought that DMT is not meant to be used without Harmalas and not meant to be used for high dosings and flooding the receptors. Although I never experienced a "breakthrough" in all my experiences, even with IV dosings above 50mg that normally should have led to a breakthrough. Some experiences were very intense, maybe like a little breakthrough. But I never felt that I really hitted the breakthrough point. I also never experienced DMT machines elfs, other entities and such things.
I experienced deep personal and archetypical healings, mainly by working through what I can best describe as tensions of energy or patterns of condensed energy experiences.
My theory that or hope that the missing harmalas where the key to profound experiences again as DMT and Harmalas maybe are made for each other and that Harmals are even necessary for a balance in the nervous system are a bit diminished by murklans experience that the fading of DMT effects happened to him also with Harmalas.
So maybe we need just time.
But with other drugs I have experienced permanent changes in effect. For example with nitrious oxide. When I was a teenager - 16 years ago or so - nitrious oxide always caused a ringing in my ears - a phenomenon sometimes referred to the nitrious oxide helicopter sound. After less than 100 nitrous oxide capsules or so this effect completely faded. And even after more than a decade of not using nitrous oxide and just recently testing it again. The helicopter sound never came back.
I hope the DMT magic and pronounced benefits will come back!
My advice to others based on my current experiences: Better not take it daily for a long time, take breaks and don't dose too high (better take more harmalas to deepen the trip) as the nervous system might not be made for high doses of DMT.