The only further thing I can suggest for you is to continue searching for more detailed articles on the pharmacology metabolism and pharmacokinetics of levocetirizine. If you find something that seems relevant and for whatever reason you can't access a full paper, we can help you with that, as well as with interpreting the findings of any such paper.
I can understand that chemical and medical terms can be a bit daunting - I feel the same way about the more arcane aspects of computer programming, for example - so I'm happy to provide assistance in your pathway towards understanding these things.
https://go.drugbank.com/drugs/DB06282 - this page lists the major metabolites (which are somewhat incidental, given that about 85% of the drug is excreted unchanged), and has a handy interactions section, e.g.:
Quote:Moclobemide The risk or severity of adverse effects can be increased when Moclobemide is combined with Levocetirizine.
and also, most importantly
Quote:This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Just to re-iterate - while I'm happy to help you in your pathway towards understanding, we really can't give out medical advice. The main thing to be aware of is, in my view, the question of whether Passiflora would decrease the urinary clearance of levocetirizine leading to a risk of overdose. Quite a lot of work has been done lately by the European medicines and health agency on herbal medications so it's likely there would be something there about known interactions from Passiflora, albeit not necessarily with levocetirizine.
https://www.ema.europa.e...erbal-medicinal-productshttps://www.ema.europa.e...herbal/passiflorae-herbaIt seems there hasn't been much research reported here^ on the grounds of established traditional use!
This pdf contains the most information:
https://www.ema.europa.e...incarnata-l-herba_en.pdfE.g.,
Quote:Constituents:
Flavonoids, mainly C-glycosides of apigenin and luteolin, e.g. isovitexin, isoorientin and their 2"-Ξ²-D-
glucosides, schaftoside, isoschaftoside, vicenin-2 and swertisin, with considerable variation in
qualitative and quantitative composition according to source (Hänsel et al., 1994; Bradley, 1992;
Wichtl, 2004; Barnes et al., 1996; 2007; ESCOP, 2003; PDR for herbal medicines, 1998; Weniger &
Anton, 1996).
Maltol which, however, may be an artefact (Hänsel et al., 1994; Bradley, 1992; Barnes et al., 1996
and 2007; ESCOP, 2003; Weniger & Anton, 1996).
Essential oil in trace amounts comprising more than 150 components (Hänsel et al., 1994; Bradley,
1992; Wichtl, 2004; Barnes et al., 1996 and 2007; ESCOP, 2003; PDR for herbal medicines, 1998;
Weniger & Anton, 1996).
Gynocardin (a cyanogenic glycoside) (Hänsel et al., 1994; Bradley, 1992; Wichtl, 2004; ESCOP, 2003;
PDR for herbal medicines, 1998; Weniger & Anton, 1996).
Ξ²-carboline alkaloids (e.g. harman, harmol, harmalol) may be present in traces. However, these
alkaloids are undetectable in most commercial materials (ESCOP, 2003).
A tri-substituted benzoflavone derivative (Dhawan et al., 2004). The presence of this substance in
Passiflora incarnata has later been questioned by Holbik et al.,2010, who were unable to repeat
isolation of the substance from plant materials of three different geographical origins.
The effects on the urinary system of the substances named in the flavonoids section is where I would suggest you start looking.
βThere is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
β Jacques Bergier, quoting Fulcanelli