As I have described a few times here before I use DMT for treatment of 'Treatment resistant depression'. I used to use large doses of Psilocybin but had a bad experience the last time that made me hesitate and pushed me toward DMT. I find a DMT breakthrough dose to be effective but not as effective as a Psilocin breakthrough dose meaning the long term benefits aren't as long term as with the Psilo. I was reading a thread the other day with a chart that listed the 5ht receptor binding properties of various alkaloids and noticed nn- does not bind to the 5ht1 receptors at all yet psilocybin and LSD do. This gave me the idea that I could do a lower dose of Psilocybin/LSD (or maybe both in conjunction) along with a breakthrough dose of DMT to 'fill in the gap' and possibly get the same relief I get through taking massive (we're talking 2oz of KSSS or 14g + of Albino) dose of mush while having a much more manageable experience. I know about Harmalas and Rue but am more interested taking this route rather than the MAOI route for various reasons.

I would like to hear from someone with experience combining these substances with some possible dosage/combination recommendations. I have in my possession right at 1000ug LSD and plenty of mush and DMT. I am prepared to describe whatever experience I have combining these substances as well. Any helpful information would be greatly appreciated.

Hey my friend,

I enjoy DMT with both LSD and mushrooms. Is definitely potentiated by each, so you may need a lot less DMT to achieve a breakthrough if you're on mushrooms or LSD also. I unfortunately have not engaged much with these combinations, but intend to more.

I find that when doing this exercise with mushrooms, the mushrooms are potentiated by the DMT, so upon returning, the mushroom trip is also intensified.

I hope this helps. I look forward to seeing how it goes for you.

One love

Sounds good. I've had this idea that doing DMT while on maybe 7 grams or so of mush will provide comparable therapeutic benefits to the huge doses I previously mentioned. I will give it a shot Friday, I would try today but I ate a gummy last night that turned out to be weaker than I intended and need a few days to be sure my receptors have a good 'rinse'. I may even go with the Albino and a smaller dose like 3.5g. I appreciate the help Voidmatrix and whichever I decide I will report back here.

I enjoy DMT with mushrooms. Usually during the mushroom comedown. Good stuff.

I include availabilty of DMT dosages as standard preparation of set and setting for both mushroom and LSD explorations.
I consider it to be that important.
For me, anyway.

Same here. I don’t always smoalk, but I always have it available and ready for my trips. Sometimes in the peak of mushrooms my gvg is just singing like a siren, beckoning me to come and join it. I find the pre flight anxiety and the general cannon blast feeling softened to more of a sling shot level. Absolute wonderful combination.

I'm seriously considering 250 mics LSD along with 3.5 albino this time and wait at least an hour before breaking through. Thank you all for your responses. I will be taking my journey on Friday.

LSD + shrooms - I absolutely love that combo! It will be very interesting to hear how it goes with adding DMT to that.

I was able to do my depression treatment last night and it went 'swimingly" well. Psilocin and LSD are such a lovely combination. I made tea from 3.5 grams of AA+ and PE mixture at 1800, covered it and let it sit until about 8. I make tea by boiling with the lid on for 10 minutes, I add Wylers beef bouillon to help with the taste, I strain the solids with a magic butter maker strain bag then reduce to a manageable amount of liquid, this time that was about 4 oz. I drank the tea at 2051, chased it with a small amount of "grape drink" and inserted 250ug LSD under my tongue then got in the shower. I had fasted for most of the day in preparation for this, I did eat some "pf Chang" rice at about 1300 and had one can of monster. While in the shower I could feel the psilocin begin to take hold. I got out of the shower and dressed and looked at the clock, 2111. I sat down in my living room, my wife and her friend were watching shark tank and I just sat and kind of watched. By 2130 I had absolutely amazing CEVs and a lot of fractal OEVs with the occasional "translucent serpent" and "Secret Society Seal" appearing as overlapping OEV/CEV. We watched the new episode of "Invasion", strange show.

Going back to the serpents and seal, I've had these visions for a long time when I take psilocin in particular, I see these serpent like forms that move unpredictably in a strange but fascinating way and they will form a seal like a crest with the letter "S". Last night I actually heard a voice explain the seal but I can't recall exactly what they said.

After Invasion me and my wife migrated to the bedroom (we have a California King memory foam mattress with electronic adjustable frame, she had surgery in March and the bed frame is awesome. Great investment.) We turned off the lights and put 9n the new episode of "The Foundation". I was told by my sponsor that it is based on a book or series of books and I've really liked the show up until this point but after last night I think it is not only my favorite "Sci-Fi series" I have ever seen about three quarters into the episode my brain made a connection and I started recalling events before they happened. I believe these books may have been some of the roughly 8,000 or so books I have read in my lifetime.

We have a 55 inch TV and reasonably awesome sound system in our room so with the bed in a "reclined" position I was in an "uncontrollably comfortable position" to be completely immersed in what was to come next. At this point the LSD and Psilocin was working full blast. The images were coming out of the screen and into the room with us. It was such a visually and audibly intense experience, absolutely beautiful and captivating. I could feel the "electricity" and sounds were coming from all around me. I was completely immersed.

After "The Foundation" ended I got out my DMT pens and warmed them up but still had some pre-flight anxiety. My wife put on a show called "Hightown" absolute garbage. So bad it's actually funny. I sat there for an entire episode and when it was over I "nutted up" and went for the breakthrough. I inhaled 25mg of DMT and held it for what seemed forever. It was very strange. I saw the swirling 'symbols' and they momentarily overtook my entire field of vision. I felt the propulsion and suddenly the "five nights at Freddy's" crew appeared then slid to the side with the "arcade console controls" (it's not the actual FNAF characters, they are the best description I can give though. They also appear a lot in my visions. They are more playful than anything.) I felt my pineal pop but the weird part is I didn't enter hyperspace so much as it came to me. I could feel the energy for an extended period of time, maybe 45 minutes. My visual activity definitely was through the roof during this period. Afterwards I was hungry (I never can eat while tripping) and had some raspberry Danish and a hand full of Hot Fun Yuns. No queasiness or stomach discomfort at this point. Afterwards I went to go to sleep. I laid down a 245 or so. I tried to sleep and it took a while to get there. Had to get up at 6am to make sure my 15 year old son who is on the verge of truant went to school then went to sleep. I think I got right at 6 hours (I have been sleeping 10+ lately and still feel tired constantly) and feel well rested and energetic.

My mind is clear and I feel really good. The reset was effective even without the 'ego death' or the super intense breakthrough I was anticipating. I have a hypothesis that "reset" can be achieved for people like me without taking amounts of the that can be difficult or hard to manage by combining the substances as I did and hitting all the 5ht and adrenal receptors in combination. I will continue to use this regiment in the future as needed and will report back all findings and experiences. I usually need a reset about once per month, next time I won't wait until I have needed it for too long.

Quick question about 'microdosing' DMT between "therapeutic doses". Dosage and frequency of use would be very helpful to me. I'm trying to develop a "care plan" and follow it as if it were prescribed. Thank you to everyone who has responded to this thread thus far, I sincerely appreciate your help.

Yesssss! Successsss! Very happy for you!

I'm going to give you a hard time: You drink Monster?!?!?!!

The way you described how the space came to you is very similar to my experience with freebase as of late. After inhaling, it seems to sometimes be devoid of a come up and I am just there instantaneously. Pretty wild.

And I agree and advocate for the idea that we don't have to go so far as to having an experience that is hard to handle in order to have a healing, resetting, therapeutic experience. It's sometimes about coming up to the proper edges. Sometimes it's just about doing it even if it's just a little bit.

With regard to your question, I believe Faidman stated that a microdose regimen should be roughly every three days. With DMT, microdosing is 10mg or less, but I find threshold doses to be a bit more effective, so between 10mg and 15mg (even though I am highly sensitive, and many unexpected things can happen at 15 mg for me. Depending on the week, I will work with DMT once a week to almost everyday of a week.

One love

Thank you Void. It's really amazing how much it affects my brain chemistry. I feel like a completely different person today. I am making this a promise to myself to stay on top of this as self care so I don't have to be in that dark place of despair I have been in for the last month.

I feel that! Depression is sneaky. I still sometimes have a hard time interacting and working with entheogens when I need them the most. All a work in progress. I am in a chop wood/ carry water, "deep rest" mode presently, and I've decided that part of that will include psychedelic work. Bearing in mind when I need to stray away in order to integrate.

One love

I do sometimes smoke a pipe of DMT on the peak of acid trips.
Dosage 250ug + 50mg:
Of course you get where you want but the come up is much smoother and when you come down you feel totally sobber wich is a pretty weird feeling because you are peaking on acid actually.

love is out

Also there was nothing better for treating my depression than sitting down to a tree, after ingesting mushrooms.
Mushrooms heal my soud like no others of the tryptamines.