I was wondering if anyone has experience of regular use of microdoses, but selecting the appropriate agent based on the structure of the week. Assuming a 9-5 M-F type of work week, I would like to demonstrate what I mean with the following example:

Saturday: use of ~10 mics LSD in AM for focus on academic study all day (Goal: ADHD stimulant alternative)
Sunday: in the afterglow of previous day's LSD, continue to study (or possibly ~20 mics LSD for another heavy academic day)

Monday thru Friday: ~5-6 mg of DMT in the morning prior to work in conjunction with meditation (Goal: improved connectivity with others and problem solving insight through expansion of consciousness)

Friday evening: ~0.3mg of mushrooms while playing a musical instrument or socializing with others (Goal: improved creativity of musical insight. Focus on cherishing the meaningful relationships in my life)

This is a framework I see that could be useful and is almost certainly a more aggressive schedule than I would actually follow. But I believe it paints the picture of selecting the appropriate agent for the intended outcome, and using each of them on a weekly basis.

Has anyone had any luck of following something like this?

I'm not sure if 0.3mg shrooms would even consider micro-dose... it's more like nano-dose, too little to effect imo.

Yeah, I would also bump up that micro-dose, at least to 0.6g for a more lasting effect, or somewhere according to your body-weight and sensitivity.. or even just slightly raising the dose on the last day in your weekly plan could do wonders. Everything else seems fine, though.

I tried 0.3g during a md protocol and didn't notice a thing but something is indeed active whether we like it or not. It wasn't until I hit the 0.5g md where something was apparent but virtually undetectable. And that's okay. The point in micro-dosing is to, in essence, re-train your brain and various transcription factors in favor of enhancing hippocampus neurons and functional thought, not 5-HT2A psychedelia.

There should be something different and apparent in your awareness that you can't put your finger on - without any alternation in consciousness, something you can remember. But if its your last md day on Friday eves, I'd suggest without any 'significant' alternation in consciousness.

All the best!

I did do a lot of microdoses, or even combining few microdoses together to good results.
I think your idea good and you could try it, but as sbios mentionned, unless it is a typo and you meant 0.3 grams, 0.3 mg mushrooms isn't microdose but nanodose, it likely won't do anything at all IMO, beside possible placebo.
So I would encourage you to try that with 300 mg mushrooms ( I imagine you're talking about cubensis ? but even withother mushrooms, if its for socializing and music,you should be good or even could take a low dose to get a bit of a vibe also and once a week relax, or combine the 0.2 g to 0.4 g mushrooms with low harmalas dose especially if you do'nt drink alcohol during your friday evening social andmusical gathering ).
The LSD and DMT dosage sounds good.

I tried microdosing LSD earlier this summer.

On my first try, I tripped balls.

On my second try, I tripped balls. (1/2 dose of 1st try)

On my 3rd try, I was very, very productive. (1/4, 1/8? dose of second try)

Just make sure you know your tabs or vials or whatever as best you can.

I've found on many occasions that a low dose of DMT is highly anxiolytic, and I never tried microdosing mushrooms

I've only microdosed LSD so far. Thought at those doses they're supposed to be such light effect won't notice much or anything? From my understanding it's about letting it repair connections in the brain and from those repairs you eventually see the changes in depression. Etc.

Yes, forgive me. Indeed, I mean 0.3g of P. Cubensis, or 300 mg. Thank you for noticing that.

Actually, you bring up my next point very fluidly. The use of harmalas to have a "trip" without obliterating the 5-ht2a receptor sensitivities. This would also allow for continued use of these microdoses into the next week without the need to take a 2 week abstinence for receptor sensitivities to reset. Do you have thoughts for how to achieve this?

Due to use of stimulant medicines for ADHD which I have successfully just discontinued (first successful MD of LSD today!), I am relatively naive to MAOIs experientially, though I have read quite a bit about them. I also have caapi leaves, THH, and Harmine both in HCl and FB forms.

Some thoughts I have are simply the use of changa when seeking deeper experiences. But I have yet to try psilohuasca and am very very curious.

I am particularly curious in potentiating the mushroom as you speak of, without giving it the "serious" tone that seems to be a common feeling when fully inhibiting with 3-5g of syrian rue (in combination with about 1g of mushrooms). Keeping it light and playful, but also potentiated would be the goal.

Your post gave me a good hearty laugh hahaha! Yes, I have very reliable tabs and just created a tincture following this protocol, creating a solution that is 1 microgram for each 1 ml of solution (112.5ml dH2O + 37.5ml 40% etOH + 150 ug LSD soaking for 24 hours).

Today was my first go at it with 11 micrograms and it was a booming success! I completed more in 6 hours than I have in the last 6 days.

Knowing your tabs, as you say, is key to this being a reliable and successful method.

What you say is true. While no sense of psychedelia, visual alterations, or anything of that matter was present today on my 11 microgram dose, I could not deny that I sensed a feeling of vibrating at a higher frequency than normal. Perhaps something akin to a cup of coffee in the morning.

You are correct! Ha, I meant 0.3g, thanks for catching that.

I posted on the other topic you posted in regarding microdosing mushrooms and harmalas. 0.5mg/kg of Psilocybin should be the maximum limit for avoiding 5ht2a tolerance. (I'll post my source when I find it again)

Beta-carbolines have low affinity for 5ht2a receptors.

Unsure how the receptor densities will react with more Psilocybin floating around due to MAOI. Worthy of experimentation, I will be trying a similar regimen, 5 days on 2 off.