In my experience mushroom extraction is much more difficult than I imagined a priori. Based on what I have learned after failing many times, here is where I would reccomended starting to make progress:
1) Use Na+ cation ion resin (high quality resins are available at filter supply stores for example). Get some pure amino acids from a health supplement store and practice with those zwitterions first to get a feel for binding and eluting from the resin. You'll want to elute at gentle pH with the help of salt I believe. Search the forum, there is a paper where they also added a certain amino acid as a control that elutes in a similar way to psilocybin.
2) The 4-OH position loves to make the indoles oxidize and polymerize when not protected. It's a pain in the butt. You may have to invest in setting up a vacuum system (doesn't have to be too expensive, just get a good pump and suitable container/air lines). Otherwise it will polymerize if exposed to air, or light, if you try to dry it, if you tell at it, or if it senses you are in a bad mood (j/k, but you get the point). I would seriously look at also getting a small cheap freezer and drilling an air line into it so you can freeze dry this stuff. A promising thing would be to freeze dry an elution with |
High Pobability of Braindamage by Creepy non tested Drugs (forced by scammer 69ron) | and form a stable complex that won't degrade.
There are also A/B descriptions in the literature, and it is possible to do A/B into xylene and salted with fumaric (as shown in this forum after a lot of hard work), but yields are not that good at all and it is stinky/troublesome (not reccomended at this time).
Good luck and I wish you success. Let is know if you find something that works 🙃