Hi,

I would like to hear your opinions regarding vasoconstriction.I was searching why I crave beer and cannabis as I don't think I had LSD without bit of Guiness to 'take the edge off'

My blood pressure was high before avarage daily readings 150/95 over 24h period but that turned out to be cancer in my kidney,tumour size of table tennis ball.
After the operation my BP went back to normal levels,now especially during lock down my stress levels were near zero and BP is best it has ever been in recent years.

Last month I had tried 1pLSD had one there as a gift and was surprised by the speedy come up and my BP jumped to 160/100 and pulz 125...that was about 30min in.
My brother had the same reaction,we are pretty similar weight,hight and age too.190cm and 100kg,in our early 30s... I got worried when I was testing on my own 1st and my brother is a doctor so suggested 250mg of Magnesium and I was even scared to have a beer as it is RC and was getting a bit worried.

On mushrooms,cubensis species I don't even think about drinking beer and don't feel my BP is going up much.I have been messuring it over last 5 years pretty much 3x a day so I kind of know now give or take but still do messure.

I have been reading reports of people on reddit having similar issues,some chest pains etc but not many are realizing what is going on on physiological level.And when I see posts 3x 1p LSD or other doses in 500micro range I wonder what their BP must be...

Think it is 1 in 3 or 4 people have high BP without even knowing about it.Here in the UK your BP gets messured maybe once or twice a year if you go for a blood test but I see posts people testing their tabs but not many messure basic things like your BP...

What are your thoughts on this? Do you feel your BP going up on LSD?

When I have DMT and not mushrooms or LSD before I can feel my heart jumps right up and I am sure BP too but there isn't much time to messure as it doesn't last long anyway to reach dangerous levels-however not sure where I read someone's grandmother suffered stroke smoking DMT in her 70s...not sure where I read this.
My main concern is LSD as it last at least good 8h for me and sometimes I drop half way so it last even longer.

Harm reduction at the end of the day

edit:
I usually take 2 tabs and they suppose to be 100-15-125micro never more
with mushrooms I hardly go over 2.5g these days
Cannabis oil daily 100-250mg a day,CBD oil about 100mg,volcano vapes went throught the room during lock down and recent events too
Thanks to lockdown I discovered DMT and had time to read,research and test

I have read Rick Strassman's book 2 years ago before my diagnoses and there were reports of elevated BP and some test subjects had to be taken off the research due to high BP.
That's why I never went ahead with DMT ,think back now that was the main reason...4 months later my tumour was found and it made sense.

Also, as a still technically classed as cancer patient I feel my use before diagnoses and after the treatment were helpfull.
No PTSD (yet even spoke to specialists and I myself work in mental health so I know kind of what's what and what to look out for (not sure anyone knows 100% what is going on as no one can see inside your head.I work with complex people with learning difficulties and autism on various spectrums)
My GP had a suspission of PTSD due to me coming in asking for testosterone hormone level test as felt my libido was well down-maybe caused by massive doses of cannabis...was on 200mg of good RSO a day plus vapes maybe 3g of bud a day
testosterone levels came back on low side so my suspision was correct,not going to be treated just taking it easier on weed and added some strengh exercise and one portion of red meat a week.


I have been treating my symptoms -back ache and high BP good 2 years prior to my diagnoses but was using mostly commercial 'strong' strains like lemon haze or skittlez mainly 50-50 hybrids and my BP was going sometimes to 180/110,after about 1h went to 120/80 and sometimes later 110/70
These days I went back to pure Indica strains.landraces and also CBD plants indoors.
when I wake up my resting pulz is about 50-55.I have donecycling and swimming pretty much all my life,don't exercise with weights but only my own weight,mainly pull up bar

sorry if I am writing all this in maybe wrong forum but don't have much access yet to participate elsewhere

Most if not all psychedelics including LSD, DMT and mescaline share near identical cardiovascular effects. One study I recently looked at using mescaline as the prototypical psychedelic made mention of how it's physiological effects overlap with that of norepinephrine and epinephrine. That is effects such as tachycardia, hypertension and other adrenaline like effects not related to the cardiovascular system such as dilated pupils and increased perspiration.

Looking at the these side effects it goes without saying that psychedelic drugs are indeed risk factors when it comes to inducing events such as strokes or myocardial infarctions. However with that being said, most of them including DMT and mescaline do generally have good safety records when it comes down to recreational, clinical and traditional use with very few cases of people becoming fatally ill as a consequence of their use.

IMO it seems that most of the cases I've come across where a psychedelic drug such as ayahuasca or 5-MeO-DMT does unluckily result in a fatal outcome, it often involves self harm, dangerous drug combinations or a pre-existing medical condition such as CVD.

IME, magnesium helps a lot with that. When i used to trip on lsd, i would take 1 magnesium pill in the morning and one just before dropping and my memory is such that it made a big difference in body load.

Funny that you mention beer craving... it was the same for me. i usually don't drink but always had a beer or 2 while on acid.. it just felt "right".
Bear in mind though that in large quantities alcohol becomes a vasoconstrictor.

@monomind

yes true that.I try to stay with Guiness as that's only 4.1% but once managed to drink 1.5l vodka with juice .... ashamed of myself to this day

magnesium is known to lower blood pressure a bit but Rick Strassman had for emergency Nitroglycerin (?) was couple of years ago I read the book

the 'body load' is basically the increase in blood pressure which makes you a bit unfomfortable on the come up ,my last reading after 8h on 150micro LSd was 128/85,maybe that's why i prefer to take LSD in stages lets say i have 2 tabs but 2nd dose 3h after the 1st one.Like when they merge together but it is smoother this way IMO