For reasons that aren't fully understood (just as covered by some of the posters on pages 8 & 9 of this thread) the actual plant brew from good Hawaiian psychotria can be many times more powerful, all encompassing & longer lasting than anything that can be purified out & added back in. This is poorly understood, it could be the superior salt form of the actives in the leaf, or other components along with the leaf + the dynamics of digestion of the leaf form. Traditional Ayahuasca can be quite powerful & long lasting with good plants and considered to be caapi + psychotria by the Shuar Indian, UDV, and Santo Daime. It is safe and traditional. Benny Shanon in his book "Antipodes of the Mind" also mentions he used caapi + psychotria for all of his 130+ sessions. Recommendations for good caapi would be yellow cielo caapi vine or caapi extract. Recommendations for good leaf would be Hawaiian psychotria.

Clearlight experiments that involved several people back in the day (over a dozen trials) found the leaf brew form superior to extracted actives, they found the leaf brews very strong and powerful & clairavoyant (+5 Shulgin scale), while they mentioned that the extracted actives were mild (+3 Shulgin scale) at best, even up to 100mg. Again, this is poorly understood, but refer back to page 8 & 9 of this thread for more info.

Even Jonathan Ott found that in his 20 experiments posted in his book "Ayahuasca Analogues", that none of his later experiments with extracted actives quite matched the power of his 1st actual Ayahuasca brewed with caapi and good real leaf (experiment #1), he had no explanation for this. He did however find 70mg to be close to it, but still not the same.

In dreams, a brew of blended up psychotria leaf can be boiled in 1 and 1/4 bottle of spring water (21oz) for 1/2 hour, then filtered thru a wire mesh strainer to get out the course leaf fragments, then filtered thru a cotton ball in a funnel to get out the fine leaf sediment, changing out the cotton ball when/if it clogs. Having two large funnels, each sitting in a separate glass with a cotton ball stuffed into each funnel's tube, and transferring the liquid back and forth between the two funnels when the cotton would clog up, allowed the filtering to go fast and would only take up a few minutes at most. Then put the filtered liquid back on the stove and reduce it down to 2oz, and add your caapi. Phenomenal dream with good plants. The cotton ball gets out any fine muddy leaf sediment which is irritating to the intestines, for a nausea free to the stomach/intestines brew, this of course does not reduce "brain nausea" which can result from using too much leaf.

Taking a small sip of the leaf brew (before adding the caapi to it) can be done to determine the approximate "strength" of the leaf beforehand...depending on how bitter a sip of it is, you will be able to help gauge whether the admixture part (light) of the dream will be weak, medium, or strong ornamentally. If it's too crazy bitter, back off on the leaf amount used as this may signal a "too strong" leaf brew. The leaf brew and caapi (power) are taken mixed together (marriage) at the exact same time (just as the Shamans do) for best & strongest effects ornamentally.

As a poster on page 7 posted, the 1st 60 minutes from when the caapi takes effect is when some weak nausea or slight dizziness might be noticed during the dream, whereas after the 1st hour, there is usually little to zero nausea or dizziness as the harmine in the caapi has mostly worn off by then, as the half-life of harmine is around 1.5 hour. Then all that is left working is the more desirable tetrahydroharmine in the caapi and any leaf actives for the duration of the rest of the dream.

Why traditional caapi over rue?

Just as Bancopuma wrote earlier, "the more caapi the better." Caapi contains tetrahydroharmine as it's second largest alkaloid, and contributes greatly to the experience in many postitive ways, besides it's visionary, brightening and coloring abilities, it goes way beyond that....it seems to partially inactivate barriers or filters in the brain so that "mind at large" as coined by Aldous Huxley can be let loose a bit.

Mind at Large: https://en.wikipedia.org/wiki/Mind_at_Large

Tetrahydroharmine on it's own will also yield the same type visions as harmaline, it just takes more of it. For example, around 300mg of THH will yield the same visions as about 100mg harmaline...even if the THH dose or caapi dose is split in two over several hours, the visions will still be apparent some time after the 2nd dose takes effect, the doses are additive.

THH in the caapi also seems to strongly activate the right hand hemisphere of the brain-- the side that performs tasks that have do with creativity and the arts, feelings, visualizations, imagination, holistic thinking & intuition, empathy, spirituality & connectedness. In the first book mentioned below, researchers found that the right side of the brain lit up in brain scans of people who took LSD, mescaline, or mushrooms. The world is largely moving in the direction of the Left Brain: technology and science. What the world needs is to move in the direction of Right Brain development.

Quote from TIHKAL by Dr. Shulgin "More studies on tetrahydroharmine are absolutely imperative."

I have definitely noticed differences between smoking freebase from acacia vs mimosa. I have only taken pharma a handful of times, each time using spice frebase from mimosa and harmala freebase from rue.

As far as I can gather from what I've read, 5meo in chaliponga is misinformation.

...Two times this combination of alkaloids led to wonderful experience. The third time, I became extremely out of my comfort zone, I felt like I was drowning, it was a harrowing ride...