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Converting 5-meo-Dmt freebase to salt form Options
 
thecosmiclizard
#1 Posted : 5/2/2020 12:52:08 AM
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I have just began to experiment with this substance I am still easing my way in and have yet to actually smoke/vape the compound. I tried insufflating it recently to minimum effects but I would like to try again after converting the compound to a more suitable form for this ROA. What is the easiest way to do this? The only info I can find is doing the reverse process converting salt to freebase.
 

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downwardsfromzero
#2 Posted : 5/2/2020 2:17:15 PM

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Choose your anion, then add the corresponding stoichiometric amount of the appropriate acid. The solvent system you use will depend upon this choice as well.

FASA for DMT might inform you of a possible direction to proceed. https://www.dmt-nexus.me....aspx?g=posts&t=2546




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Brennendes Wasser
#3 Posted : 5/2/2020 5:34:20 PM

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The cheapest and easiest way would be to use Acetone from a hardware shop and solid food-grade citric acid from any drug store (is it called that way?). You can often buy drying agents at hardware shops, too, but they come with some plastic stuff which you would need to throw away just to keep the drying agent (CaCl2, Silica is bad for this).
But it would be an interesting thought if hardare store home-usage-quality Acetone would even have so much water inside, that it would justify a drying step.
 
thecosmiclizard
#4 Posted : 5/3/2020 6:06:27 AM
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I've read the dmt handbook's section on salting and it seems simple enough of a process. Is 5meo and nn-dmt similar enough in structure for the salting process to be the same, I know I have to take the different molar mass into account but thats just changing the variable in the equation they provide in the handbook.
 
Brennendes Wasser
#5 Posted : 5/3/2020 12:14:24 PM

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The 5-MeO-group does not change any reactivity regarding salt conversion. Actually, it is even quite unreactive to anything. You have to use quite nasty chemicals to cut that group off from the molecule ...

So by simply adjusting the molar mass you can just proceed as you would. Keep in mind to slowly mix any acidic solution with your 5-MeO-solution as otherwise (upon very fast mixing) you may drop your 5-MeO in another molar ratio and this may let some 5-MeO stay freebased in the solution.
This may happen with acids with 2 protons like citric acid, fumaric acid, malonic acid, but you should still use them, as they are the only one to produce resistant salts which do not collect moisture from air. Just dont throw everything together at once and you will be safe.

EDIT/PS: Actually it may not be even better to convert it to the salt form, if you seek to insufflate it.

I guess your aim is to create a water soluble form, which would in theory be taken up in the nasal system much faster compared to an unpolar compound. Very often I read here on the Nexus that a lot of other compounds show a LOWER activity when applied as the salt form, for example bufotenine - which seems to be much weaker when applied as the salt, so weak that you are definetly required to use the freebase.

That may be due to the fact that indeed a salted ionized molecule is dissolved nearly instantly in the nasal mucus and may then be absorbed into the capillary system of your nose. But on the other hand the pharmacodynamics of the drug may require a step where a transport through membranes will take place. And this is heavily slowed down for ionized molecules. And this may be the reason why a lot of drugs should be administered as the freebase in order to actually increase the uptake speed. As Bufotenine (5-OH-DMT) is quite similar to 5-MeO it may actually be the same case for 5-MeO. Maybe keep a tiny portion of 5-MeO as the freebase, then when you have both ready you may insufflate a tiny portion which would just be above the minimal dosage required for a noticable effect - while measuring time. Then you would know if any of these both forms is less effective regarding potency and based on other substances it may actually be the salted form Wut?
 
 
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