Hi all, sorry for such a noobish question for my first post, but if I took 5-htp 6 hours ago, am I OK to take same harmine now? Is their dangerous interaction only for the duration of the 5-htp's effect, or does it last 24 hours or something? Many thanks

72 hours is recommended.

Further information can be found here.

Thank you!

Totally 72hs. Both these are strong at brain stimulation, would probably cause overstimulation. In that same vein, its good to fast on everything except maybe just fruits, no caffeine or sugar stuff, and drink Aya (MAOI.) All this is based on the body's ability to recuperate. If you had very good sleep and meditation and all good natural food you would probably be good in 24-36-48hs. Its about not overstimulating, about going into the state of least exaltation (pure breath), not over stimulation which would be unpleasant. For this; care in all things consumed. 5HTP is strong. Its very useful.

I expanded on that a bit havent I

Thanks Fran, I appreciate the expansion

I'd been taking the 5-HTP to bolster serotonin in the wake of taking MDMA, but I didn't really notice any psychoactive effects from it whatsoever, unfortunately. Still good to go through the motions I suppose, and in theory it helped. My mood was fine anyway after the MD, so that may have accounted for the lack of effects.

I see. We were taking a different product though, maybe straight 5HTP isnt that strong. I was using this which is entheogenic at the 1 serving size


Mood & relaxation*
For serotonin production*
Plus L-theanine, rhodiola, saffron and holy basil
A comprehensive formula designed to support mood and relaxation.* Central to this formulation is 5-hydroxythryptophan (5-HTP), a naturally occurring amino acid that is the immediate precursor of serotonin.* Griffonia simplicifolia, a climbing shrub, helps the body to naturally produce this hormone, helping your attain an improved state of well-being.*

To complement the benefits of 5-HTP, this product also features L-Theanine that helps to increase alpha brain waves thereby supporting relaxation of the mind and body.* This product also includes other botanicals such as Rhodiola and Damiana that have been used traditionally to support mood and relaxation and in doing so, helps promote a more balanced state of mind

Hey there, missed you the first time around.

Welcome to the Nexus!

Thanks! Haven't posted much because I'm not yet sure how I can contribute, but I'm tremendously grateful to all you guys for teaching me so much.

Why would a link that describes the half-life of harmalas be relevant in determining how long after *5-HTP* one can take harmalas?

And is there any conclusive evidence that combining 5-HTP and harmalas is dangerous? I read one post describing a pleasant synergy between Passionflower extract and 5-HTP...

5-HTP is apparently safe to be taken alongside reversible MAO-A inhibition. I've been taking 50 to 100mgs of 5-HTP plus 300mgs of L-Dopa Mucuna extract and 50mgs of P5P B6 (for DOPA Decarboxylase action) with my Rue and there hasn't been any negative interactions, although personally 5-HTP and L-Dopa are better when i give them 2 full hours to kick in before taking anything else including the Rue, so i'll usually get them in my system first and then 2 hours later take the Rue, although for about the last week i was dosing them 30 minutes into the Rue, it still worked alright but not as good as taking them 2 hours before the Rue.