DMT-Nexus member
Posts: 122 Joined: 16-May-2019 Last visit: 07-Jun-2024
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5-meo to nn . Is there an easy way to cleave the methyl oxy group off ?
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Boundary condition
 
Posts: 8617 Joined: 30-Aug-2008 Last visit: 07-Nov-2024 Location: square root of minus one
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This question has been asked time and again, and the answer is still the same - NO. (And I don't mean "use nitric oxide" either.) βThere is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work." β Jacques Bergier, quoting Fulcanelli
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DMT-Nexus member
Posts: 122 Joined: 16-May-2019 Last visit: 07-Jun-2024
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I was unaware . Can't blame me for trying . I did an initial search already. No much came up. So I gambled
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analytical chemist
 
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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not a chance. The covalent forces binding the methoxy to the benzene ring are too strong. substitution and cyclization to a beta-carboline would occur well before the methoxy even budges. "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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Boundary condition
Posts: 8617 Joined: 30-Aug-2008 Last visit: 07-Nov-2024 Location: square root of minus one
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I typed "removing methoxy" into the search function and found this: https://www.dmt-nexus.me...&m=903738#post903738 βThere is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work." β Jacques Bergier, quoting Fulcanelli
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Chairman of the Celestial Divison
Posts: 1393 Joined: 21-Jul-2010 Last visit: 11-Aug-2024 Location: the ancient cluster
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lol yup you might as well demethylate, convert to triflate, then instead of hydrogenolysis with palladium, just do some transition metal coupling chemistry and stick on a trifluoromethylthio (-SCF3) group instead. You run into just as much effort and difficultly converting into that as converting it into -H , believe me. haha. And then at least you'd have a novel DMT molecule on your hands The better starting point is 5-Br-DMT  Expect nothing, Receive everything.
"Experiment and extrapolation is the only means the organic chemists (humans) currrently have - in contrast to "God" (and possibly R. B. Woodward). "
He alone sees truly who sees the Absolute the same in every creature...seeing the same Absolute everywhere, he does not harm himself or others. - The Bhagavad Gita
"The most beautiful thing we can experience, is the mysterious. The source of all true art and science."
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DMT-Nexus member
Posts: 764 Joined: 18-Jan-2008 Last visit: 20-Mar-2023
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I wonder why bother. 5-MeO-DMT is much more scarce than NN-DMT Do not seek the truth, just drop your opinions.
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DMT-Nexus member
Posts: 1104 Joined: 11-Feb-2017 Last visit: 18-Jan-2021
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...especially since it's much easier to go from tryptamine to NN than from 5-MeO to NN.
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DMT-Nexus member
Posts: 2096 Joined: 20-Nov-2009 Last visit: 12-Nov-2023
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I don't see why either.  And I do'nt have the answer. I mean you could dislike 5 meo and like n,n and want to change your 5 M into n,n... But 5 meo is very thought after, you could prolly make someone happy with giving it away / trading. Thing to try is rather go from Mexamine to 5 MeO. Smell like tea n,n spirit !
Toke the toke, and walk the walk !
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