Sublingual psilocybin trials have been approved.

Does anyone know how psilocybin was made sublingually active? All I can find are vague mentions of polymer nanoparticles, but no specifics so far...

I'm looking too to no avail. It seems they're primarily disolvable strips, so the psilocybin presumably is absorbed through those sublingual membranes, bypassing the gastrointestinal tract. But no mention of actual production method of the product.

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That'll be part of where they want to be making their money, on the patented delivery method.

I wonder if it involves | High Pobability of Braindamage by Creepy non tested Drugs (forced by scammer 69ron) |?

Thanks guys. I haven't been able to find what they use to make psilocybin sublingually active. I guess it is a mystery for now...

The attached review is the most relevant info I have been able to find.

Chitosan is mentioned and is interesting. It can be made into ~250nm size polymer spheres.

Maybe it is worth adding OTC chitosan to a mushroom tincture and test for sublingual activity 🤷‍♂️.

Sublingual psilocybin was explored here years ago. Ice house was talking about successfully quidding mushrooms over a decade ago, and a number of us were using psilocybe tinctures both sublingual as well as snuffed with positive results.

Psilocybin is already active as a sublingual drug, so you will be looking for an increase in effect rather than simple activity.

Here's an idea for an experimental method. Would alkaline quidding of mushroom powder perhaps do the trick? A pinch of lime, a pinch of cornstarch and a pinch of powdered shrooms might be worth a try. I would suggest mixing with the lime immediately before quidding because psiloc~in becomes unstable in alkaline environments.

Chitosan is derived from chitin, and chitin is the principal structural material of mushrooms:

Obviously, pure chitosan is readily available for purchase, but the intrepid (cheapskate) researcher will see that any one of a number of naturally-occurring materials (insect wings?) would be a pretty good source of fairly pure chitin. A simple pre-treatment with sodium - maybe even calcium - hydroxide followed by neutralisation should furnish some level of deacetylation. Besides that, some fungi produce a certain amount of chitosan as it is.

This looks like a good read for would-be chitosan nerds: https://www.sciencedirec...pii/B9780128179703000146

For the record, I'm starting with 90% deacetylated chitosan. Above 85% it is considered water soluble.

Thanks for the feedback Jamie. This would be to increase bioavailability then.

Watch, in a week Loveall is going to be telling us how to make our own psilocybin sublingual strips ha!

I'll be waiting

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I can attest, my experience with fresh mushrooms is that If I chew them throughouly and hole them in my mouth, the psychoactive effects are felt immediately albut subtle, lingering until the remainder of the alkaloids become active via oral route.