I'm new to 5-MeO-DMT and cannot find much on what kind of tolerance of frequency is built up by smoking or insufflating it. I'm familiar with n,n DMT and know that it can be smoked once a week, with no tolerance build up (or perhaps even more frequently) but I was not sure if the same principles apply to 5-MeO-DMT? I would assume so, but I would like to hear from other who have smoked or insufflated it.

I'm trying to build my exposure to 5-MeO-DMT, as I've heard too many horror stories to just go for a big dose, and I'm trying to slowly work my way up to an effective dose. If done once a week, will that allow adequate time for my sensitivity to go back to baseline? Can I get away with experimenting twice a week?

I also should point out that my ROA is insufflation with HCL. Being new to this route, is there any danger in using this ROA several times a month or is it relatively safe?

From what I've read online, 5-MeO tolerance lasts only a few hours tops.