I have read on Known substance-interactions and their effects link that this is a bad idea even though I have read ketamine is safe with MAOI while MXE isn't but I could not find any information on n20 (nitrous oxide). Does nitrous oxide effect serotonin system like MXE making it dangerous? Would the short duration actually make it something to be of concern?

Funny that you ask, SWIM actually tried this combination today. It boosted the effects quite a bit and was quite pleasant. Slight headache now, but that could be from other things.

Yes indeed, If I do more than a pack of 10 I will feel sick and a bit anaesthetised.

Once I did 5-10 packs in a row combined with DMT and it was a very bad move, the whole next day I couldn't get out of bed I had such a headache.

Anybody have any evidence about the interaction here?