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Syrian Rue and Strattera Interaction? Options
 
HarryPotter
#1 Posted : 8/22/2015 4:53:58 PM
I've found varying sources say to go off Strattera anywhere from 6 weeks prior and 4 weeks afterwards of taking ayahuasca (http://thewayinn.com/safety-guidelines), to 5 days prior and no mention of afterwards (http://forums.ayahuasca.com/viewtopic.php?t=8062).

I'm looking for reputable sources to answer this question, and ideally an explanation about why.

One source said "STRATTERA should not be taken with an MAOI, or within 2 weeks after discontinuing an
MAOI. Treatment with an MAOI should not be initiated within 2 weeks after discontinuing
STRATTERA." I think the 2 weeks number may come from the time it takes with pharmaceutical irreversible MAOIs to regenerate the body's MAO enzymes, which may not be relevant for Syrian Rue which is a RIMA and takes I think about 12 hours to wear off.

There seems to be conflicting information within the minimal amount of information I could even find on this.
 
corpus callosum
Medical DoctorModerator
#2 Posted : 8/25/2015 2:14:21 AM
HarryPotter wrote:

One source said "STRATTERA should not be taken with an MAOI, or within 2 weeks after discontinuing an
MAOI. Treatment with an MAOI should not be initiated within 2 weeks after discontinuing
STRATTERA." I think the 2 weeks number may come from the time it takes with pharmaceutical irreversible MAOIs to regenerate the body's MAO enzymes, which may not be relevant for Syrian Rue which is a RIMA and takes I think about 12 hours to wear off.

There seems to be conflicting information within the minimal amount of information I could even find on this.


^^The source quoted above matches the advice in the product monograph for atomoxetine (Strattera) which makes no distinction between MAOI types.Its use in ADHD can take a couple of weeks to become fully apparent and relates to its effects on the presynaptic norepinephrine transporter, an effect which lingers for a time after atomoxetine has been discontinued and reflects the important concept that pharmacological and pharmokinetic half-lives do not always match. This also is supposed to make this a less abusable agent than other compounds used in treating this condition. Its metabolism is largely dependant on CYP 2D6, and this can vary from 5-20 hours depending on the phenotypic expression of this enzyme.

The potential risk with MAOIs and Strattera is a hypertensive crisis and on occasion a picture similar to neuroleptic malignant syndrome.
I am paranoid of my brain. It thinks all the time, even when I'm asleep. My thoughts assail me. Murderous lechers they are. Thought is the assassin of thought. Like a man stabbing himself with one hand while the other hand tries to stop the blade. Like an explosion that destroys the detonator. I am paranoid of my brain. It makes me unsettled and ill at ease. Makes me chase my tail, freezes my eyes and shuts me down. Watches me. Eats my head. It destroys me.

 
 
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