Once I made a side by side extraction of rue, half grinded, half whole. While the whole rue was easier to filter, the yield was significantly smaller too (cant remember the numbers).
Then infundibulum did the same thing and got equivalent yields. That was confusing

Since then I have heard of some people having success with whole rue but not really anybody doing controlled side-by-side tests.
I`d think if you do extended boiling or even better, use a pressure cooker, whole seeds might be good enough, and in case you get a very bad yield, just go back to the seeds and grind them and boil another time to see if you can get some more.