I should hope someone here is familiar with adenanthera peregrina, aka yopo, and its disgusting snuff form, which I have used recently.
But a new idea struck me:
Let's turn it into an ayahuasca analogue. This seems like a reasonable thing to do, right?
You're likely going to puke with the snuff anyway, so it would behove us to instead turn it into a worthwhile 3 hour trip or so.

That being said, what might be the optimal way to do things, given approximately:
7% 5-OH-DMT
~.1% N,N-DMT
~.04% 5-MEO-DMT

how would one reasonably dose to have a proper ayahuasca-like experience with
A: Syrian Rue (peganum harmala)
B: B. Caapi

I look forward to an educated discussion, because since the seeds are still legal (apparently our Inquisitors are not overly concerned with us snorting calcium hydroxide) and available on mainstream websites (no sourcing, I know, but it's legal, so let's bend the rules a bit.) there is no reason NOT to start using this substance as an analogue for the hard-to-find stuff needed to make the real white mind-cannon.

This is already a thread. Click Here

First off, bufotenine is a Schedule 1 substance, as is DMT. So Yopo/Cebil seeds would fall into the same legal grey-area as MHRB or ACRB. Meaning that technically, because they contain a Schedule 1 substance, they are illegal. But they may have other traditional uses, so they are sold with a disclaimer somewhere along the lines of, "NOT FOR HUMAN CONSUMPTION".

Secondly, using A. colubrina/ peregrina in an ayahuasca-like beverage would produce a completely different experience than traditional ayahuasca with DMT as the main psychoactive component. I feel like I have read a report of someone experimenting with this idea, but I couldn't find that thread. From my understanding, 5-HO-DMT has a much lower LD50 than DMT. That would make the idea of bufohuasca more dangerous than traditional aya, if I am remembering that correctly. But I might be wrong on that. It seems that in the other thread I posted and elsewhere on The Nexus, people aren't really sure of the safety/risk of oral 5-HO-DMT ingestion.

What I do know, from experience, is that 5-HO-DMT comes with some pretty severe uncomfortable side-effects. Like vasoconstriction, intense nausea (even without MAOI), and an all-around toxic physical feeling. I feel like you would need to add a few things to the brew to try to minimize these side-effects, but no matter what they will still be there. Ginger helps a fair amount with the nausea, and theobromine is a reasonably effective natural vasodilator. Cacao has a pretty high theobromine content, so perhaps it could be used in the brew.

In conclusion, I probably wouldn't recommend bufohuasca.

What's up Nexians..

I've been considering exploring Bufotenine for a bit and was considering the different ROA's available....

I hear that when smoked alone, bufotenine is nice, but not nearly as nice as when combined with harmalas....I also hear that it makes dmt visuals quite a bit more "three-dimensional" than usual (at least when smoked in "bufochanga".

I tend to like ROA's that promote extensive duration of experience.....so I was thinking oral ROA would be a good idea....however, this brings about the problem of nausea and other physiological effects, supposedly...........these however can supposedly also be offset by preloading either with lemon oil, or 2-4 datura stramonium seeds (or perhaps both unless there's a reason not to combine those?)

So this is what i'm thinking.....since Bufochanga with spice in it seems to be so greatly appreciated by those who have tried it, how about preloading with oral harmalas and lemon oil , before then ingesting isolated spice and bufo together (in a ratio of preference) via a concentrated ethanol or vinegar tincture (orally or sublingually). Would this make for a very 3D/4D, nausea-free, bufohuasca/pharmahuasca? Could potentially stretch their spice supply greatly by adding a small amount of bufo to the mix, right? It's a lot easier to extract a gram of bufo than it is a gram of spice, and a far lower dose is used, especially when used in conjunction with spice, I would imagine..