I just posted the following question also in this thread: https://www.dmt-nexus.me...aspx?g=posts&t=14012
but i guess it is more approbiate here:

How long do you usually wait after taken Harmals until you

1. drink alcohol (moderately)
2. drink alcohol (heavily)
3. take 5-HTP
4. take Mescaline
5. do MDMA

I would appreciate answers also based on experience. Thank you.

^^There is variability between individuals in there ability to process harmalas which relates to differing levels of functionality of the relevant cytochrome P450 enzymes; for this reason there will be no one 'right answer' applicable to all.

Thank you for the quick and informative answer corpus. I´m very aware of different metabolisms and should have formulated my question maybe differently. I was just curious about some personal experiences which could help as a guideline. I´m just currently wondering if one could have a few drinks at a bar, considering he did do pharmahuasca the night before. I guess i will figure that out anyways and post the result.

Thank you for rearranging the thread. Now, i´m really happy to hear some experience reports on taking different stimulants/alcohol/whatever after enough waiting period since the ingestion of harmalas.

I can start and say that i had a protein shake and coffee the morning after pharmahuasca. I maybe can say that the coffee made me a bit nervous but this could also be delusive. Otherwise i didn´t feel anything special (except the wonderful afterglow of the night before)

Usually we westerners have an idea that mixing alcohol with ayahuasca is bad idea, but I'm not sure how much of that is related to contextual aspects and the fact that westerners relationship to alcohol is often of abuse, and how much is related to incompatibilities between the substances themselves. For example The Shuar drink fermented alcoholic drinks in the same ritual as they do ayahuasca (I can check the source for you some other time, it's from an anthropology book. EDIT: here).

Personally I dont drink alcohol so I can't say from my own experience though. I've heard some people having massive headaches drinking beer after ayahuasca, not sure how common that is. If you want to try, please take only very small amounts at first.

As for mescaline and MAOIs, in theory we thought it was a very bad idea to mix phenetylamines such as mescaline with MAOIs, but there have been quite some people experimenting with this mixture and they claim it seemed safe, at least from a subjective viewpoint. Do a search on 'San Paapi', I think was the name they gave to san pedro+caapi.

MDMA, I'd wait for 24 hours at least, to be safe. It's definitely not good idea to mix MDMA and caapi, it's potentially deadly and this is no exageration (there have been cases described in literature of people that died taking RIMAs and MDMA, I can look for the paper later too).

As a tip, look for the half-life of substances, and then you have an idea how long it takes to clear the substance. IIRC one should wait for at least 3 times the half-life of the substance to consider it generally gone? Corpus Callosum can clarify this for us

Like endlessness Im not a drinker of alcohol but as a CNS depressant, using alot of it with RIMAs is inadvisable.

MDMA is an interesting one; its half-life is generally regarded as being 5-8ish hours, give or take a little, but one of its metabolites is MDA which has a half-life of upto 12-13 hours.MDMA to MDA requires CYP2D6, an enzyme which can be inhibited by harmalas.The kinetics of MDMA metabolism also change with use of bigger doses.CYP3A4 is also important in processing MDMA and this too is inhibited by harmalas so in order to be safe I would personally leave a gap of 3 or more days, assuming I'd used a not too large dose of MDMA.

Imo, it depends largely on the dosage of harmalas.
Harmalas followed by depressants such as Alcohol would be the least of risk, I`d say they could be done the next day for moderate drinking, and 2 days after for heavy drinking.
However, following up stimulants with stimulants eg Harmalas followed by MDMA could be risky, I`d wait 3 or more days.
I have taken rue with mescaline and can tell you do NOT try that combo, extreme blood pressure rise, felt like my blood would pop out my skin. I`d wait 3-4 days till I tried Mescaline after harmalas.
5-HTP, I am unsure on.

Thank you all for the answer and guidelines. I much appreciate it. From an intuitive approach i would never do MDMA within 3 days after Harmalas. So this coincindentally matches your given time frame corpus. I guess i would wait at least a week, if i ever feel the wish to do the both that close. I mean there is also really no need to do this. Just to be safe, i would also apply the same rule to Mescaline, although i have just read a bit about the san paapi. Thank you for the hint endlessness and much respect for those who bioassay such combinations.
So after the really special night yesterday (2oo mg Harmine and 80 mg Fumarate) i cautiously will have a few beers tonight and later post how it felt. I guess it will be fine like shane suggested.

Offtopic:
Just because i´m still excited about last night (it was so much body, maybe not enough fumarate) i want to share, that i managed to touch the ground with my hands while standing with full stretched legs for the first time in my life. This happened without intention to do so. I had my eyes closed while "trippin over" leting myself go and just float. All of the sudden i touched the ground, opened my eyes and was really happy to see this had happened. Couldn´t repeat it that morning tho....

So 3 beers within 20 - 24 hours after 200mg of Harmine-HCl didn´t cause any headache (could be possible due to too much vasolidation (please correct me if i´m wrong corpus)) to SWIM and his metabolism @ 90kg.

Hello Endlessness,

I'd be interested to have the reference of this book.

Thanks !

Maybe I'm reckless but I've done all of those things except used MDMA on my daily dose of harmalas, which is usually 70-150 mg dosed twice (once in the morning, once in the evening; I'm 96 kg). I drink heavily more frequently than I should but have not noticed any negative interactions with harmalas other than that they might come on a bit stronger if I'm very hungover. Doses of mescaline have been low to moderate, but the experiences were pleasant. And the harmalas definitely potentiate it. Mind you my harmala doses might not be enough for complete MAO inhibition.

haha that is a great feeling... I remember the first time I was able to touch my toes after 22 years of being alive and never doing it.

This really surprises me since ive only read positive things about the rue + mescalin combo. What was your dosage of rue and mescalin ? Do you have a natural high blood pressure or something like that ? Were you on any kind of medication ?

It sounds like a really horrible experience especially considering the long half life of mescaline. If ill ever come around to trying this combo ill start at very low dosages.

I had a rather unpleasant interaction with harmaline and picamilon and / or Niacin. I’m not a chemist or a doctor so my understanding might be a little crude but here is what I believe may have happened.
Picamilon is a nootropic that is a synthetic combination of niacin and GABA. It is hydrolyzed into it’s constituent parts once it crosses the BBB. Unbeknownst to me, it is also a mild MAOI.
Niacin on its own is known to increase the amount of histamine in the body. (related to the process of methylation?)
Apparently , harmaline is a histamine N-methyltransferase inhibitor, which breaks down histamine in the brain, along with DAO in the body.
The net effect, I believe, was an extremely high level of histamine in the body. The symptoms included burning eyes, extremely raw and sore throat, incessant post nasal drip, chest congestion, coughing, and difficulty breathing which all continued well beyond 24 hours.
My understanding of the mechanism might be off but I just wanted to post my experience as a heads up of a possibly dangerous and definitely unpleasant interaction.
So, please be careful with combining (don’t?) the nootropic Picamilion or large doses of niacin with harmaline.

I must be an horrible being to quote myself but i think it's appropriate here :

And worst than quoting myself, commenting my quote :
I believe the strong headache was due to an high blood pressure but who knows...

And why the first time with stronger doses i had no problem is a mystery but as i said before, i won't repeat this kind of experience (burned once not twice).