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DNA Dark Matter - no more "Junk DNA" Options
 
ziggus
#1 Posted : 9/5/2012 7:00:55 PM
Among the many mysteries of human biology is why complex diseases like diabetes, high blood pressure and psychiatric disorders are so difficult to predict and, often, to treat. An equally perplexing puzzle is why one individual gets a disease like cancer or depression, while an identical twin remains perfectly healthy.

Now scientists have discovered a vital clue to unraveling these riddles. The human genome is packed with at least four million gene switches that reside in bits of DNA that once were dismissed as “junk” but that turn out to play critical roles in controlling how cells, organs and other tissues behave. The discovery, considered a major medical and scientific breakthrough, has enormous implications for human health because many complex diseases appear to be caused by tiny changes in hundreds of gene switches.

Full text here:

https://www.nytimes.com/2012/09/...s-crucial-to-health.html
 
ModeratorSenior Member
#2 Posted : 9/5/2012 7:35:01 PM
Very interesting! Thanks for sharing Thumbs up
 
benzyme
Moderator | Skills: Analytical equipment, Chemical master expertExtreme Chemical expert | Skills: Analytical equipment, Chemical master expertChemical expert | Skills: Analytical equipment, Chemical master expertSenior Member | Skills: Analytical equipment, Chemical master expert
#3 Posted : 9/5/2012 7:55:29 PM
the term "junk" DNA is rather misleading, they are backup copies for
DNA repair. this concept has been entertained by biochemists/molecular biologists for
at least a decade. translocation by retrotransposons may play a role in how they are integrated in newly synthesized DNA; the odd thing is that 8% of the human DNA genome has retroviral origins.
"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
 
Vodsel
Senior Member | Skills: Filmmaking and Storytelling, Video and Audio Technology, Teaching, Gardening, Languages (Proficient Spanish, Catalan and English, and some french, italian and russian), Seafood cuisine
#4 Posted : 9/5/2012 8:15:43 PM
benzyme wrote:
the odd thing is that 8% of the human DNA genome has retroviral origins.


Why is it so odd? I mean, unless that is a unique human trait... A host infected by a retrovirus that has not damaged the host's abilities to reproduce will spread on. In thousands of generations, one would expect to see an accumulation effect. Also, symbiosis is stable.
 
benzyme
Moderator | Skills: Analytical equipment, Chemical master expertExtreme Chemical expert | Skills: Analytical equipment, Chemical master expertChemical expert | Skills: Analytical equipment, Chemical master expertSenior Member | Skills: Analytical equipment, Chemical master expert
#5 Posted : 9/5/2012 8:45:08 PM
the retrotransposon functions attributed to said dna make it odd.
solve some of those mysteries, and we would possibly be staring at the
basis behind evolution
"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
 
proto-pax
Senior Member
#6 Posted : 9/6/2012 1:19:01 AM
Vodsel wrote:
benzyme wrote:
the odd thing is that 8% of the human DNA genome has retroviral origins.


Why is it so odd? I mean, unless that is a unique human trait... A host infected by a retrovirus that has not damaged the host's abilities to reproduce will spread on. In thousands of generations, one would expect to see an accumulation effect. Also, symbiosis is stable.



It's thought that retrotransposons have some effect on inducing cancer within humans, which makes sense. The gene "jumps" and inserted itself into a proto-oncogene resulting in the production of an oncogene.

http://www.ncbi.nlm.nih.gov/pubmed/20715060


blooooooOOOOOooP fzzzzzzhm KAPOW!
This is shit-brained, this kind of thinking.
Grow a plant or something and meditate on that
 
benzyme
Moderator | Skills: Analytical equipment, Chemical master expertExtreme Chemical expert | Skills: Analytical equipment, Chemical master expertChemical expert | Skills: Analytical equipment, Chemical master expertSenior Member | Skills: Analytical equipment, Chemical master expert
#7 Posted : 9/6/2012 1:40:11 AM
as the abstract mentions, that's one theory of cancer (aside from faulty error-correction proteins). gene-jumping may have other implications as well
"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
 
 
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