Hello nexians,
In this topic I'd just like to ask anyone to share any information and/or opinions they have about the dissasociative ketamine.
I'm inquiring in terms of this hypothetical situation...

Let us say for example, there is such a person whom enjoys using ketamine occasionally.
That person, once in his youthful years had had his run with it, got bored with it and moved on.
but then!...
One night while tripping on acid, this person came across some ketamine... and tried it again and decided he liked the combination. In fact, he liked it very much.
He liked it so much so that the following weekend, he decided to take mushrooms and repeat the same procedure with ketamine.
With mushrooms, this person decided that he enjoyed this,as well.
So he continued to explore.... and found that he also enjoyed the combination with 2ce and mescaline and so on and so forth.
He remembered four or five years ago when he used to use ketamine alot - that he never liked mixing it with psychedelics.

Now, past his phase with this infamous dissassociative, suddenly they're seems to be a slight affinity for the chemical growing anew.
Maybe because all those years ago, he was less experienced... who knows, but now he finds that ketamine can add an interesting dynamic to the tail end of a psychedelic trip and would like to continue his occasional use.

HERE's THE TWIST-> Wanting to brush up with his familiarity on ketamine (since it had been so many years since this person had used it)
he proceeds to look up some articles on erowid...
and what does he find...?

A plethora of what would appear to be almost *WARNINGS* to stay away from disassociatives [pcp, dxm, ketamine, n2o alike]

What used to be a few short mentionings of Olney's lesions or what could happen with continuous over-use/routinely, now has transfused into seemingly, a much more serious matter.

To be clear... my question is concerning the dangers dissasociatives [mainly ketamine] can inflict on the brain...?
It seems to have become a greater concern than once was.

I'd like to know what people think in terms of occasional use.
Is this one of those chemicals that is best completely avoided now?
Also if anyone knows how methoxetamine fits into the picture?

The warnings usually are geared to rather heavy users, and the main issue seems to be "bladder syndrome", Basically you can seriously damage the bladded if you do too much k.

Perhaps you would drastically reduce the risks by only using it very occasionally for say special occasions. Another issue with K is that people do kinda end up overusing the stuff, and this is another problem to potentiate possible bladder damage.

MXE, is supposedly more bladder friendly, although this has not been proven.

-As for the rest, DXM, PCP,etc....who knows, the possibility of brain damage i guess greatly diminishes with less usage, etc.

>> Clearly these compounds carry risks, and are not to be reccomended. However if you do decide to use them, use the utmost care based on this knowledge, and do more google research. There's quite a bit on the bladder syndrome, some kids wear catheters-for life!!

Im not sure of brain issues, but there's several publications out there reporting bladder damage from ketamine (for regular long term users). Avoid taking it regularly and in large doses, spread out your sessions, maybe once a month or whatever.. The thing is that ketamine and other similar dissociatives have an addictive aspect to them, so do try to be aware of your use. Maybe taking longer breaks once in a while helps you get some perspective on your use pattern.

The other issue with ketamine is the physical danger of accidents, because of it being at the same time an anaesthetic, dissociative and psychedelic.. So you might be moving around and hurt yourself but not even notice, or things like that.. Having a sitter and/or being in a physically safe place and avoiding moving aroudn too much would be good recommendations, also depending on the dosage you take.

Methoxetamine is so new that there's very little, if any, info on its potential toxicity. Its gonna take a few years (and some reckless people exceeding the sensible dosages and regularity of use) to get more info on it, so while that isnt happening, better keep it more sporadic and not be too excessive with doses.

Im no expert, but I have done my experiments and I know people who took it for years. I suggest you to be careful with it, because it's quite addictive and the side effects can kick in quite quickly (e.g. ketamine bladder syndrome). Just keep listening to your body and see how you feel after using it. Anway, Im not sure about the brain damage, nonetheless it has recently been found out that it could be used in the treatment of depression: http://www.npr.org/blogs/health/2012/01/31/146096540/i-wanted-to-live-new-depression-drugs-offer-hope-for-toughest-cases

EDIT: Sorry, I just saw the other guys posts.

Ketamine seems to have effect on short term memory and attention in regular use (and heavy use) also, something as bad as with smoked canabis. Something we most often forget about it's side effects.
http://www.ucl.ac.uk/new...s-articles/0911/09111701
http://www.nda.ox.ac.uk/wfsa/html/u04/u04_010.htm

ty everyone for the responses and info.
I will say that rather than scaring me or convincing me more so to cease and arrest, instead I feel a lot better and safer about occasional use.
So again, ty, I really appreciate it.