Why would Salvinorin A or 5-MeO-DMT be more able to penetrate the skin and into the bloodstream than DMT?
Are there any specific properties that Salvinorin A, 5-MeO and other transdermally active alkaloids share, that DMT does not have?

Scopolamine and LSD, for instance, are both known to slip right through the skin into the bloodstream. Why is this so?
I imagine the skin, like the stomach, liver, and mucusmembranes, also has an enzymatic breakdown system, that allows some substances to pass
through, directly into the bloodstream, while it enzymaticly breaks down other substances before passing them on into the bloodstream?
Maybe only very small molecules can pass through the skin and freebase DMT is too large a molecule to pass through?

Anyone with any knowledge concerning this, please clear this up.

Seraph asks

A. nilotica (Gum Arabic Tree) has been found to contain DMT (see african tyrptamine species list in Trying to improve Acacia information...)

SKA wrote

..DMSO can carry substances through the skin & into the bloodstream (as also can oil of Wintergreen & Chinese nitrogen mustards)..therefore i believe the sublingual experiment worked because of the DMSO..
..my one attempt years ago at making a DMT/DMSO salve (approx 60mg, rubbed under arms) resulted only in mild activity, but i would like to hear of more these experiments...

several people have tried this, and reported little to no effect. there are other threads about it here.

..yeah benzyme, that's usually what i've heard.. the sublingual DMSO route could be more promising though...

err, sorry I thought id clear this up,

Gum Arabic is used as a filler to make these pills for medication. Like many plants the tree this substances comes from contains a very small amount of DMT. This would be similar to chewing phalaris grass, but even less.

I assure you gum arabic has no psychoactive compounds at all. Your experience was placebo or from the caffeine.

Although I find caffeine extremely psychedelic myself so I don't doubt it

Have you ever heard about dmt mixed with coconut oil and then applied to skin?

This particular thread, speculative musings, and accidental anecdotal reports are what initially inspired me to conduct the coco oil transdermal dmt experiment as seen here:
https://www.dmt-nexus.me...&m=538497#post538497

A few of us have shown that it does indeed work but coconut oil is a bad choice. I didn't realize it doesn't absorb well at all. DreaMTripper pointed out how you should test different oils to see which one your skin absorbs best. The best that I have found so far is shea butter. I use it for a cannabis salve and absorbs almost 100%.

Some think this is a waste of dmt but I think it is a novel use for a number of reasons.