Definitely have gotten more sensitive to these things over the years. Kind of took a break from much of it. Took a break from pretty much everything tbh [aside from cannabis].
For instance [somewhat random], I recently smoked a couple hits of cannabis along with 25mg noopept. Years back when I'd first tried noopept I used to dose it somewhat consistently and would smoke cannabis with it occasionally with no issue. I smoked some the other day after taking 20mg noopept and the initial buildup of effects of the canna was almost too much for me [this had definitely never been the case before], not a freak-out by any means, though the best way I can describe it is when you get a good dose/hit of cannabis and the initial buildup and that overall feeling that can come over you and sometimes be almost 'too much' at times [hard to explain] - well that feeling felt magnified by what seemed like a hundred-fold.
Not to say this was directly caused from years of psych use, as there's probably a massive amount of seen/unseen factors aside from that that led to me being more sensitive now than before [i.e. age, life experiences, etc].
Also, I know for me it doesn't take much to go far with changa, dmt, or mushrooms now. Got to tread much more lightly than before. I know when smoking changa or vaping dmt it feels like i'm always, for lack of a better phrase - lubed up and primed.
Whereas before it took me 'going for the gusto' to get where I wanted to go; now though it's much...much easier, effortless.