I have been researching this field quite a bit lately, nothing serious, just hobby research, but have ultimately moved away from the notion of microdosing, and into the field of exploring psychedelics with nootropic potential. The goals of microdose users seem to be quite similar to the goals of nootropic consumers, improved focus, improved concentration, improved memory, added inspiration*, improved performance, improved creativity, improved productivity, and so on.
Now, I feel psychedelic pharmacology is essential here, as non-psychedelic nootropics seem lacking, so I began to search for psychedelics with nootropic potential.
Around 1999 I was given a copy of "Certain Exotic Transmitters as SMART PILLS or Compounds that Increase the Capacity for Mental Work in Humans A story about LAZAR as told by Hosteen Nez", this publication is focused on 2,5-dimethoxy-4-methyl-phenethylamine, or "2C-D", which shows great potential. In 2015 Darrell lemaire revealed himself as the author (both authors), and again this publication was back into my focus...coincidentally simultaneously while I was researching microdosing and nootropics. It can be located in full
HEREI think 2C-D holds great promise, specially for microdosers, and in cases where 2C-D may be "too stimulating" it seems lemaire found a suitable alternative:
Quote:Meg, found that 2CD was a little too strong for them; they mostly felt that it "wired them up" excessively. The compound was tamed by replacing the two methoxy groups on the ring with two ethoxy groups and resulted in 2CD-DiEt (4-Methyl-2,5-diethoxy-phenethylamine) which retained the smart pill activity and eliminated the tendency towards states of intoxication.
https://erowid.org/chemi...amp;replacenum;2ct2-diet So, 2,5-diethoxy-4-methyl-phenethylamine is another nootropic psychedelic with very promising potential...
*
Quote:Anamnesia said: So, the other day I took a small amount of mushrooms and proceeded to begin reading a book called Grammatical Man: Information, Entropy, Language, and Life. Of course, as always happens for me with psilocybin, anything and everything becomes enormously interesting.
* "added inspiration" explanation
this covers the phenomena mentioned previously regarding being fascinated by most anything, which can be easily explained:
Quote:In addition, the locus coeruleus (LC) is
often referred to as the "novelty detector" for salient external
stimuli. One would predict that sensory events that may not
ordinarily seem remarkable may be perceived as having "increased
novelty". This is indeed one of the effects commonly reported by
users of hallucinogens (Nichols, 2004).
http://www.123helpme.com/view.asp?id=33297 Quote:Novelty detection is accompanied by increased hippocampal noradrenergic activity, driven by enhanced firing of the locus coeruleus (LC), the main source of noradrenalin (NA) in the brain (Sara et al. 1994; Kitchigina et al. 1997). Lesioning the afferents that carry neuromodulatory inputs (including NA) to the hippocampus impairs recollection of episodic-like memory (Easton 2006). LC stimulation improves memory retrieval (Devauges and Sara 1991), whereas vagus nerve stimulation enhances memory encoding and consolidation (Clark et al. 1995, 1999; Ghacibeh et al. 2006) via LC activation, suggesting that the LC, and the noradrenergic activity it mediates in the hippocampus, may be a key factor in driving synaptic plasticity in response to novel spatial events
https://www.ncbi.nlm.nih...pmc/articles/PMC2774396/ So, through increased hippocampal noradrenergic activity facilitated through the Locus Coeruleus, you can encounter an object which you have encountered many times before, and because your brain's "novelty detection" centers are in action, it's as if you were seeing it for the first time in terms of novelty.
Links related to the benefits of microdosing
http://www.marieclaire.c...r-women-microdosing-lsd/Why Power Women Are Micro-Dosing LSD at Work
This link below is one of my favorite pieces of research related to this field:
Quote:http://realitysandwich.c...nding_cognitive_studies/A significant instance of problem solving resulted in a Nobel Prize for Kary Mullis. Until the invention of the polymerase chain reaction (PCR), a common problem in biology was that biological samples were often too small to analyze, but Mullis solved that and won a Nobel Prize. He described how LSD aided him in doing so.
"PCR's another place where I was down there with the molecules when I discovered it and I wasn't stoned on LSD, but my mind by then had learned how to get down there. I could sit on a DNA molecule and watch the [indistinct] go by. . . . I've learned that partially I would think, and this is again my opinion, through psychedelic drugs . . . if I had not taken LSD ever would I have still been in PCR? I don't know, I doubt it, I seriously doubt it." (Mullis 1998; "Horizon: Psychedelic Science" 1997)
From the point of view of psychedelic cognitive studies,
Mullis's example is noteworthy because he did not have his insight while taking psychedelics but instead used psychedelics to increase his ability to visualize, then transferred that cognitive skill back to his ordinary mindbody state. This confirms the idea that some skills learned in one state can be transferred to another. Transference and nontransference between mindbody states is itself a cognitive process that deserves study — learning to remember dreams, for example. Learning to increase this flow, if it is possible, would increase access to stores of information and possibly to new cognitive skills.
Unlike Mullis's experience of transferring a skill back to his ordinary state, most instances of psychedelic problem solving occur while the person's cognitive processes are psychedelically augmented. This is most clearly illustrated by "Psychedelic Agents in Creative Problem Solving: A Pilot Study," by Willis Harman, a professor of engineering economic systems, and a team of researchers at Stanford Research Institute.
Working with twenty-seven men who were "engaged in various professional occupations, i.e., engineers, physicists, mathematicians, architects, a furniture designer, and a commercial artist and had a total of 44 professional problems they wanted to work on," the Stanford Research Institute team divided them into groups of three or four and gave them 200 milligrams of mescaline, followed by a quiet period of listening to music. Then they had snacks and discussed their problems with their group. Following this they spent three or four hours working alone on their problems. As a result of psychedelic enhancement, the practical results were impressive.http://realitysandwich.c...nding_cognitive_studies/
Reference links:
http://www.123helpme.com/view.asp?id=33297https://www.ncbi.nlm.nih...pmc/articles/PMC2774396/https://www.dmt-nexus.me...;t=73277&find=unread-eg