Checking a MSDS for a chemical you use is very advisable.

Still I find them quite confusing because it's not mentioned at which quantities things become hazardous.

Let's take the D-limonene one: it is classified as Extremely hazardous in case of ingestion. The problem with this, is that there are no quantities mentioned. It's added in a lot of food. It's naturally occurring in oranges and a lot of other things we consume. They even sell it in 1000 mg gel caps as a supplement.
It's even mentioned as very hazardous in case of skin contact because of the irritating effects. I always wear gloves when handling d-limonenen, but occasionally I had some spills on a uncovered skin part. I personally never felt a hint of irritation (not saying that it can't do harm)

Let's take the acetone one: it's classified as hazardous in case of skin contact. Yet generations and still removed their nail polish with pure acetone.

So where to draw the line of safety involving the handling of chemicals?

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Oh yea. Thanks guys. I learn something with every click

Find out wich of your available options has the lowest vapor point and I'd do the lime with that. Then limonene seperated and then bring together. But that's just me offering what I know. Not much research behind it

Lethal Dose tests (LD50) can be by any route of exposure. The usual ones are:
ORAL
INHALATION
CONTACT WITH SKIN (DERMAL)

Inhalation is usually divided up into VAPORS, DUST/MIST or GAS.

There's no reason why you can't do sub-cutaneous LD50 testing but it's not common because it's unlikely if you're using a substance in the normal course of your day.

Anyway if it's toxicity by swallowing you're testing, you write ORAL before LD50 by standard convention. You normally add the species it was tested on too - great!!!

Excellent information. Thank you so much. That is very curious though how limonene has a lower ld50. Maybe when it's ingested a certain way or potentiated it looses toxicity

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Maybe try to extract the 3 different isomers into 3 different solutions.
Edit: further researched the subject nd found the isomers are all chemically identical so the before mentioned would be tricky. I'd say go with what you thinks best for your solution. Good luck let us know!