SWIM wants to know, cause if it doesn't then he can do a STB with DCM in his seperatory funnel.

don't worry about it. swim has been doing it in his Labglass sep funnel for 5 years with no etching whatsoever. borosilicate glass is very resilient

thanks alot bro

I know alot of people use DCM, so can any of our local chemist comment on this little ditty. Seems like it would be a problem.

Journal of Pharmaceutical and Biomedical Analysis xxx (200 xxx–xxx
Short communication
N,N-Dimethyltryptamine and dichloromethane: Rearrangement of quaternary ammonium salt product during GC–EI and CI-MS–MS analysis
Simon D. Brandt a,∗, Cl´audia P.B. Martins b, Sally Freeman c, Nicola Dempster a,
Mark Wainwright a, Philip G. Riby a, John F. Alder b
a School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK
b Centre for Instrumentation and Analytical Science, The University of Manchester, Sackville Street, P.O. Box 88, M60 1QD, UK
c School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
Received 11 October 2007; received in revised form 30 November 2007; accepted 12 December 2007
Abstract


N,N-Dimethyltryptamine (DMT) 1 is a simple tryptamine derivative with powerful psychoactive properties. It is abundant in nature and easily accessible through a variety of synthetic routes. Most work-up procedures require the use of organic solvents and halogenated representatives are often employed. DMT was found to be reactive towards dichloromethane, either during work-up or long term storage therein, which led to the formation of the quaternary ammonium salt N-chloromethyl-DMT chloride 2. Analysis of this side-product by gas chromatography ion trap mass spectrometry (GC–MS), both in electron and chemical ionisation tandem MS modes, gave only degradation products. For example, 2 could not be detected but appeared to have rearranged to 3-(2-chloroethyl)indole 3 and 2-methyltetrahydro- -carboline 4, whereas HPLC analysis enabled the detection of 2. GC–MS is a standard tool for the fingerprinting of drug products. The identification of a particular synthetic route is based on the analysis of impurities, provided these side products can be established to be route-specific. The in situ detection of both 3 and 4 within a DMT sample may have led to erroneous conclusions with regards to the identification of the synthetic route.

The hundreds of other extractions done with DCM didn’t show that to be the case.

I believe it requires some special interaction they didn't disclose, otherwise everyone else would be getting those results and they aren’t.

That's what I figured. I know DCM works, but seeing this just kinda made me want to post up the question over here.

Whats DCM?

DCM=DiChloroMethane, CH2Cl2, a chlorinated hydrocarbon solvent

Isn't DCM heavier than water?
If you are doing an STB in a sep funnel with DCM,
wouldn't all of the bark in solution sink down into the DCM layer and clog the funnel?
Or would it stay suspended in the aqueous solution?