I was wondering.. if SSRIs diminish the effects of DMT, does that mean they also block the DMT naturally produced in our bodies?

I've been searching around and all I have found was stuff along the lines of "I want to try dmt but I'm on antidepressants" technically we've all 'tried' DMT?

Uhm, we have no idea the mode of action that dmt has on our bodies and no "we all" have not "done" dmt as smoking it and it being produced in our bodies are two completely different things.

If you do a little prodding you will notice tgere isnt a whole lot known about dmt and its production endogenously.

anrchy is correct. Tread carefully as it sounds like you are taking hypothesis as fact. Most of the modern hypothesis/theories about endogenous DMT were originally proposed by Rick Strassman in the Spirit Molecule book, but I would suggest taking the time to read that book, as it is all interesting, but most of it is purely speculation. His hands were tied during the experiment and he was not able to do much of what he wanted to do. Most, if not all, "facts" about dmt are ideas which Strassman himself explains in the book, he did not have the time nor resources nor permission to explore them, but thinks they would be interesting if someone else has a chance to check them out.

In the book, he theorizes that a constant level of DMT is being maintained, and keeps us tuned into the "channel" of reality which we normally experience. He also theorizes that imbalances in the level cause religious experiences, schizophrenia, NDEs, all sorts of stuff. There have been new articles out where people say DMT has been proven to be produced in the lungs, but if you look into those, they also quickly lead into mostly speculation.

This is an interesting read as well
http://www.scientificexp...ournal/jse_22_3_cott.pdf

Yes, it is true that we have little done research on DMT. But we do know that DMT is naturally produced in our bodies. Not necessarily the pineal gland. And we don't know if it actually is the dream molecule or spirit molecule, etc. But we suspect that there may be a use for it. Perhaps DMT can be studded by experimenting with SSRIs. There are different methods of getting DMT into our systems. Dr. Strassman IVd his volunteers but many people smoke it in freebase form. Either way, isn't it the same thing? Increasing the amount of DMT in our system? Although our naturally produced DMT is found in traces, DMT is still powerful in small amounts. I wonder what effects are present when SSRIs combine with DMT.

When I first started extracting in was on celexa and it definitely made me resistant. I needed upwards of 60mg for a proper breakthrough when 30mg will get me there every time now.

Do you mean subjectively? Like taking SSRIs and smoking/injecting DMT and looking for differences between that and smoking/injecting DMT without SSRIs? Or do you mean like using MRIs and other medical equipment?

As for the question of whether or not endogenous and external DMT is the same, endogenous traces of DMT are very small, and are balanced out by other chemicals in the body which prevent too much from building up at once. So trace amounts of DMT in the body are not the same subjective experience as IV'ing or smoking or orally ingesting an outside source of DMT.

If I remember correctly, external and internal DMT is also processed differently, but I may be wrong about that so don't quote me! lol

When I was prescribed prozac and using psychedelics years ago, I was also much more resistant like Tyler says.

no.

can you elaborate?
what exactly makes the difference in endogenous vs externally taken DMT?

The sole function of an SSRI is to block 5HT (serotonin) reuptake transporters. This function does nothing to inhibit production of 5HT, or other tryptophan metabolites occuring before 5HT.

as for any trace endogenous DMT, it's oxidized rather quickly. Exogenous DMT has to compete with high serotonin concentrations in the synaptic clefts, and well, the 5HT receptors evolved to prefer serotonin.

Well you did ask...

Is this also the reason why smoked dmt (without maoi) is more peak-ish stronger, because there is less of "competition" (the serotonine levels were not pumped up without the maoi), and hence by smoking the synaptic clefts take up more of the dmt?

yes.

the affinity of the ligand (drug, neurotransmitter, etc.) to a receptor is directly related to its structure. DMT's structure is close to serotonin's, but its concentration would need to be higher than the threshold serotonin concentration, to outcompete serotonin for active binding sites on the receptors.

I have not tried DMT yet.

From peoples experiences on Youtube, I noticed it's very similar to my expériences in meditation.
Since taking antidepressants, It was MUCH harder to attain these'meditative' states.

Just a thought...MAYBE... In meditation I found a way to 'activate' my Natural DMT production.
Antidepressants are effecting 'somehow?' my natural DMT production.

Any thoughts?

All we really know is that miniscule ammounts of DMT is found in the human body. How it works, what it's for, and where it's made is still a mystery.

I came across a pretty neat scholary article sometime ago about rabbits producing DMT in their lungs. This was while researching nuero religious sciences. (Very interesting!)