This paper says bufotenin is just as active by the sublingual route as it is by insufflation. I was thinking I would toast some Yopo seeds, grind them up, boil the powder in vinegar and let it stand for a day, then filter, and evaporate. So has anyone tried yopo sublingually(extract or raw)?

I would say just snuff it man. Bufotenine, for w/e reason is very active via insufflation, more so than other things I have snuffed. WIth sublingual odds are you wil swallow a bit of bufotenine, which is unpleasant physically, to say the least. You want to avoid any bufo in the gut if you can.

Swim is going to be doing a very thorough bioassy which is going to include smoking, snorting, sublingual, and intrarectal, with seed powders and extracts. he just wanted to know if others had tried it before him so he could know what to expect. Also if anyone has tried intrarectal administration of bufotenin or 5-Meo DMT, I would truly appreciate any advice on dosage, effects, side-effects, duration, etc.